 | | Vol. 10.34 – 1 September, 2021 |
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| Scientists showed that methyltransferase-like 14 (METTL14) , a critical component of the N6-methyladenosine (m6A) RNA methyltransferase complex, promoted global genome repair through regulating m6A mRNA methylation–mediated DDB2 translation and suppresses ultraviolet B radiation-induced skin tumorigenesis.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported that the epigenetic factor, Ten-Eleven Translocation 3 (TET3) dioxygenase was overexpressed in acute myeloid leukemia (AML) patients and functionally validated human leukemic stem cells, and was required for leukemic growth by virtue of its regulation of glucose metabolism in AML cells.
[Leukemia] |
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| The authors reported that the LGALS1 gene, encoding the carbohydrate binding protein, galectin1, is a key regulator of brain tumor stem cells and glioblastoma resistance to therapy.
[Cell Reports] |
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| Researchers found that sunitinib could have adverse effects of promoting renal cell carcinoma (RCC) progression by increasing vascular mimicry formation of RCC cells.
[Cancer Letters] |
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| Scientists designed a meta-analysis to assess gene expression profiles in different breast cancer cell lines focusing on the secretory factors responsible for conversion.
[Cancer Letters] |
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| Investigators reported deep-red/near-infrared turn-on fluorescence probes, CS5-A and CS7-A, targeted to aldehyde dehydrogenase 1A1 as an intracellular CSC marker.
[ACS Sensors] |
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| The authors reported that elevated c-Myc protein supported formation and growth of tumor-repopulating cell spheroids. The tumor suppressor DOC-2/DAB2 interactive protein suppressed c-Myc expression to inhibit tumor-repopulating cells expansion and self-renewal.
[Cancer Science] |
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| Researchers investigated the mechanism by which lncRNA LINC00261 affected the biological functions of cancer stem cells during the progression of pancreatic cancer.
[Cell Death Discovery] |
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| To understand the role of the adipose-derived stem cell secretome in breast cancer cell proliferation, death, and phenotype alteration, adipose-derived stem cell-conditioned medium was used to cultivate MCF-7 and MDA-MB-231 cells.
[Biochimie] |
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| Investigators observed that proportion of CD133+Nanog+ subpopulation in MCF-7 cells was significantly increased after 3,3′-diindolylmethane administration with up-regulated AKT activity by using CyTOF assay.
[Toxicology and Applied Pharmacology] |
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| The authors found that camalexin inhibited cell proliferation and migration of breast cancer cell lines. Camalexin also suppressed breast cancer stem cell-derived mammosphere formation.
[Journal of Natural Medicines] |
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| A better understanding of the molecular and functional landscape of pancreatic cancer (PC) stem cells-intrinsic evasion of chemotherapeutic drugs offers a facile opportunity for treating PC, an intractable cancer with a grim prognosis and in dire need of effective therapeutic advances.
[Cancer and Metastasis Reviews] |
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| The influence of nitric oxide and nitric oxide synthase (NOS) activity on glioma stem cells seem to be of particular importance. The use of specific inhibitors may allow the reduction of tumor growth and its tendency to relapse.
[Neurochemistry International] |
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| HUTCHMED initiated a Phase Ib/II study of fruquintinib in combination with BeiGene’s tislelizumab in patients with advanced triple negative breast cancer or advanced endometrial cancer in the US. This trial is to explore the potential for the addition of a highly selective vascular endothelial growth factor receptor inhibitor, fruquintinib, to anti-programmed death-1 antibody tislelizumab in inducing activity to immune checkpoint inhibitors.
[HUTCHMED] |
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| Castle Biosciences, Inc. announced that it has been awarded a five-year US Federal Supply Schedule contract from the Veterans Health Administration for its DecisionDx®-Melanoma gene expression profile test.
[Castle Biosciences, Inc.] |
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| October 19, 2021
London, England, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Sidney Kimmel Cancer Center at Jefferson Health – Philadelphia, Pennsylvania, United States |
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| University of Cambridge – Cambridge, England, United Kingdom |
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| | Indiana University – Indianapolis, Indiana, United States |
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| | Dana-Farber Cancer Institute- Boston, Massachusetts, United States |
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