Cancer Stem Cell News Volume 10.37 | Sep 22 2021

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    2021-09-22 | CSCN 10.37


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.37 – 22 September, 2021
    TOP STORY

    RASSF1C Oncogene Elicits Amoeboid Invasion, Cancer Stemness, and Extracellular Vesicle Release via a SRC/Rho Axis

    Investigators showed that the novel oncogene RASSF1C drove mesenchymal-to-amoeboid transition and stem cell attributes in breast cancer cells. Mechanistically, RASSF1C activated Rho/ROCK via SRC-mediated RhoGDI inhibition, resulting in generation of actomyosin contractility.
    [EMBO Journal]

    Full Article
    Survey results on the needs and challenges in the human pluripotent stem cell field
    PUBLICATIONSRanked by the impact factor of the journal

    FOXC1 Modulates Stem-Like Cell Properties and Chemoresistance through Hedgehog and EMT Signaling in Gastric Adenocarcinoma

    The function of the only gene overexpressed in both chemoresistant tumors and tumor tissue relative to normal gastric epithelia, FOXC1, was examined in gastric adenocarcinoma cells, mouse xenograft models, and patient-derived organoid systems, focusing on cancer stem-like cell phenotypes, metastasis, and chemoresistance
    [Molecular Therapy]

    Abstract

    miR-151a-3p-Rich Small Extracellular Vesicles Derived from Gastric Cancer Accelerate Liver Metastasis via Initiating a Hepatic Stemness-Enhancing Niche

    Researchers reported that gastric cancer (GC)-derived small extracellular vesicles (sEV) were primarily absorbed by Kupffer cells and revealed a previously unidentified regulatory axis initiated by sEV-miR-151a-3p that established a hepatic stemness-permissive niche to support GC-liver metastasis.
    [Oncogene]

    Abstract

    Fine-Tuned Repression of Drp1 Driven Mitochondrial Fission Primes a ‘Stem/Progenitor-Like State’ to Support Neoplastic Transformation

    Using a newly derived carcinogen transformed human cell model, investigators demonstrated that fine-tuned Drp1 repression primed a slow cycling ‘stem/progenitor-like state’, which was characterized by small networks of fused mitochondria and a gene-expression profile with elevated functional stem/progenitor markers and their regulators.
    [eLife]

    Abstract

    m6A Modification of circHPS5 Facilitates Cytoplasmic Export and Promotes Hepatocellular Carcinoma Progression by Enhancing HMGA2 Expression

    Silencing of circHPS5 inhibited epithelial-mesenchymal transition and CSC phenotypes. METTL3 could direct the formation of circHPS5, and specific m6A controlled the accumulation of circHPS5.
    [Molecular Therapy-Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    A Novel Peptidomimetic Therapeutic for Selective Suppression of Lung Cancer Stem Cells over Non-Stem Cancer Cells

    Investigators identified a highly specific peptidomimetic that selectively bound to the CSC subpopulation of lung cancer over the remaining cancer cells.
    [Bioorganic Chemistry]

    AbstractGraphical Abstract

    Gly-tRF Enhances LCSC-Like Properties and Promotes HCC Cells Migration by Targeting NDFIP2

    The expression of glycine tRNA-derived fragment was measured by qRT-PCR. Flow cytometric analysis and sphere formation assays were used to determine the properties of liver CSCs (LCSCs). Transwell assays and scratch wound assays were performed to detect hepatocellular carcinoma cell migration.
    [Cancer Cell International]

    Abstract

    SNAI1-Mediated Transcriptional Regulation of Epithelial-to-Mesenchymal Transition Genes in Breast Cancer Stem Cells

    Researchers performed in silico analysis of microarray data from luminal, Her2+, and triple-negative breast cancer cell lines and identified 15 relatively unexplored epithelial-to-mesenchymal (EMT)-related differentially expressed genes along with the markedly high expression of EMT-transcription factor, SNAI1.
    [Cellular Signalling]

    Abstract

    HOTAIR Contributes to Stemness Acquisition of Cervical Cancer through Regulating miR-203 Interaction with ZEB1 on Epithelial-Mesenchymal Transition

    Cisplatin-resistant and serum-free cultured cells exhibited stem cells properties. Cervical cancer stem cells exhibited greater invasion and migration compared with their parental cells, which was similar to cells overexpressing HOTAIR.
    [Journal of Oncology]

    Full Article
    Watch 'collaborating to accelerate COVID-19 research'
    REVIEWS

    RhoGTPase Signaling in Cancer Progression and Dissemination

    After years of intensive research, scientists highlight the importance of relevant models in the Rho GTPase field, and they reflect on the therapeutic opportunities arising for cancer patients.
    [Physiological Reviews]

    Abstract

    The Cross Talk between Gastric Cancer Stem Cells and the Immune Microenvironment: A Tumor-Promoting Factor

    The authors provide an overview of bidirectional interactions between CSCs and immune cells in gastric cancer, compiling relevant data about how CSCs can induce leukocyte reprogramming, resulting in pro-tumoral immune cells that orchestrate promotion of metastasis, chemoresistance, tumorigenicity, and even increase in number of cancer cells with stem properties.
    [Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Erasca Announces First Patient Dosed in HERKULES-3, a Phase Ib/II Gastrointestinal Cancer Master Protocol Evaluating ERAS-007 in Multiple Combinations

    Erasca, Inc. announced dosing of the first patient in HERKULES-3, a Phase Ib/II master protocol clinical trial evaluating ERAS-007 in combination with various agents in patients with gastrointestinal cancer, with initial focus on patients with advanced colorectal cancer.
    [Erasca, Inc.]

    Press Release

    Researchers Receive National Award to Further Study Muscular Dystrophy, Cancer and Heart Failure

    Three Virginia Commonwealth University researchers were awarded funding that will support the expansion of their health research and translation of that research into improved care for patients.
    [Virginia Commonwealth University]

    Press Release
    FEATURED EVENT

    Cambridge Cancer Epigenetics Club: Matthias Merkenschlager

    Nov 5, 2021
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Associate – Skin Tumorigenesis

    University of Minnesota – Austin, Minnesota, United States

    Postdoctoral Fellow – Pancreatic Cancer Heterogeneity

    LIRCCS Candiolo Cancer Institute – Turin, Italy

    Postdoctoral Position – Cancer Biology

    Houston Methodist Research Institute – Houston, Texas, United States

    Senior Scientific Officer – Cancer Cells in Metastatic Microenvironments

    CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom

    PhD Student – Tumor Immunology

    University Hospital of Bern – Bern, Switzerland

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