 | | Vol. 10.37 – 22 September, 2021 |
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| Investigators showed that the novel oncogene RASSF1C drove mesenchymal-to-amoeboid transition and stem cell attributes in breast cancer cells. Mechanistically, RASSF1C activated Rho/ROCK via SRC-mediated RhoGDI inhibition, resulting in generation of actomyosin contractility.
[EMBO Journal] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The function of the only gene overexpressed in both chemoresistant tumors and tumor tissue relative to normal gastric epithelia, FOXC1, was examined in gastric adenocarcinoma cells, mouse xenograft models, and patient-derived organoid systems, focusing on cancer stem-like cell phenotypes, metastasis, and chemoresistance
[Molecular Therapy] |
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| Researchers reported that gastric cancer (GC)-derived small extracellular vesicles (sEV) were primarily absorbed by Kupffer cells and revealed a previously unidentified regulatory axis initiated by sEV-miR-151a-3p that established a hepatic stemness-permissive niche to support GC-liver metastasis.
[Oncogene] |
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| Using a newly derived carcinogen transformed human cell model, investigators demonstrated that fine-tuned Drp1 repression primed a slow cycling ‘stem/progenitor-like state’, which was characterized by small networks of fused mitochondria and a gene-expression profile with elevated functional stem/progenitor markers and their regulators.
[eLife] |
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| Silencing of circHPS5 inhibited epithelial-mesenchymal transition and CSC phenotypes. METTL3 could direct the formation of circHPS5, and specific m6A controlled the accumulation of circHPS5.
[Molecular Therapy-Nucleic Acids] |
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| Investigators identified a highly specific peptidomimetic that selectively bound to the CSC subpopulation of lung cancer over the remaining cancer cells.
[Bioorganic Chemistry] |
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| The expression of glycine tRNA-derived fragment was measured by qRT-PCR. Flow cytometric analysis and sphere formation assays were used to determine the properties of liver CSCs (LCSCs). Transwell assays and scratch wound assays were performed to detect hepatocellular carcinoma cell migration.
[Cancer Cell International] |
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| Researchers performed in silico analysis of microarray data from luminal, Her2+, and triple-negative breast cancer cell lines and identified 15 relatively unexplored epithelial-to-mesenchymal (EMT)-related differentially expressed genes along with the markedly high expression of EMT-transcription factor, SNAI1.
[Cellular Signalling] |
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| Cisplatin-resistant and serum-free cultured cells exhibited stem cells properties. Cervical cancer stem cells exhibited greater invasion and migration compared with their parental cells, which was similar to cells overexpressing HOTAIR.
[Journal of Oncology] |
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| After years of intensive research, scientists highlight the importance of relevant models in the Rho GTPase field, and they reflect on the therapeutic opportunities arising for cancer patients.
[Physiological Reviews] |
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| The authors provide an overview of bidirectional interactions between CSCs and immune cells in gastric cancer, compiling relevant data about how CSCs can induce leukocyte reprogramming, resulting in pro-tumoral immune cells that orchestrate promotion of metastasis, chemoresistance, tumorigenicity, and even increase in number of cancer cells with stem properties.
[Stem Cell Research & Therapy] |
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| Erasca, Inc. announced dosing of the first patient in HERKULES-3, a Phase Ib/II master protocol clinical trial evaluating ERAS-007 in combination with various agents in patients with gastrointestinal cancer, with initial focus on patients with advanced colorectal cancer.
[Erasca, Inc.] |
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| Three Virginia Commonwealth University researchers were awarded funding that will support the expansion of their health research and translation of that research into improved care for patients.
[Virginia Commonwealth University] |
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| University of Minnesota – Austin, Minnesota, United States |
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| LIRCCS Candiolo Cancer Institute – Turin, Italy |
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| | Houston Methodist Research Institute – Houston, Texas, United States |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom |
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| | University Hospital of Bern – Bern, Switzerland |
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