Cancer Stem Cell News Volume 10.38 | Sep 29 2021







2021-09-29 | CSCN 10.38


Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.38 – 29 September, 2021
TOP STORY

An Enhancer-Driven Stem Cell-Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer

Intestinal tissue from transgenic mice and patients were analyzed by histopathology and immunostaining. Human colorectal cancer cells and neoplastic murine organoids were genetically manipulated for functional studies.
[Gastroenterology]

AbstractGraphical Abstract
Survey results on the insights and hurdles of CRISPR genome editing.
PUBLICATIONSRanked by the impact factor of the journal

SIRPα-αCD123 Fusion Antibodies Targeting CD123 in Conjunction with CD47 Blockade Enhance the Clearance of AML-Initiating Cells

SIRPα-αCD123 antibodies were generated by fusing the extracellular domain of SIRPα to an αCD123 antibody. The binding properties of the antibodies were analyzed by flow cytometry and surface plasmon resonance.
[Journal of Hematology & Oncology]

Full Article

Self-Functional Gold Nanoprobes for Intra-Nuclear Epigenomic Monitoring of Cancer Stem-Like Cells

Investigators developed unique sub-10 nm Self-functional Gold Nanoprobes as a CSC epigenomic monitoring platform that could easily maneuver into the nucleus while not producing any conformal changes to the genomic DNA.
[Biosensors & Bioelectronics]

Abstract

Adaptive Mechanoproperties Mediated by the Formin FMN1 Characterize Glioblastoma Fitness for Invasion

Researchers identified clones of patient-derived glioma propagating cells that were either highly proliferative or highly invasive and compared their cellular architecture, migratory, and biophysical properties.
[Developmental Cell]

AbstractGraphical Abstract

ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression

Mechanistically, ALDH1A1 decreased the intracellular pH in breast cancer cells to promote phosphorylation of TAK1, activated NFκB signaling, and increased the secretion of granulocyte macrophage colony-stimulating factor, which led to myeloid-derived suppressor cell expansion and immunosuppression.
[Cancer Research]

Abstract

Regulation of a Progenitor Gene Program by SOX4 Is Essential for Mammary Tumor Proliferation

Scientists investigated the loss of SOX4 in mammary tumor development utilizing organoids derived from a PyMT genetic mouse model of breast cancer.
[Oncogene]

Full Article

Tinzaparin Inhibits VL30 Retrotransposition Induced by Oxidative Stress and/or VEGF in HC11 Mouse Progenitor Mammary Cells: Association between Inhibition of Cancer Stem Cell Proliferation and Mammosphere Disaggregation

The authors investigated the effect of tinzaparin on VL30 retrotransposition‑positive mouse HC11 mammary stem‑like epithelial cells, previously reported to be associated with induced mammosphere/CSC generation and tumorigenesis.
[Oncology Reports]

AbstractDownload Full Article

Inhibition of Autophagy Mitigates Cell Migration and Invasion in Thyroid Cancer

Autophagy was upregulated across multiple thyroid cancer subtypes. In thyroid cancer cell lines, inhibition of autophagy attenuated cancer stem cell viability, cell migration, and invasion suggesting a role for autophagy in the progression of thyroid cancer.
[Surgery]

Abstract

Stereospecific Inhibition of AMPK by (R)-Crizotinib Induced Changes to the Morphology and Properties of Cancer and Cancer Stem Cell-Like Cells

While (R)-crizotinib induced changes in morphologies or sizes of cells, (S)-crizotinib did not. Pretreatment with (R)-crizotinib suppressed the proliferation of cancer or CSC-like cells in vitro and tumor growth in vivo.
[European Journal of Pharmacology]

Abstract
Explore scientific events this October with the Science Events Calendar.
REVIEWS

Glial and Myeloid Heterogeneity in the Brain Tumor Microenvironment

Investigators discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma.
[Nature Reviews Cancer]

Abstract

Lung Cancer Stem Cells and Their Clinical Implications

Mouse models of lung cancer have shown that lung CSCs reside in niches that are essential for the maintenance of stemness, plasticity, enable antitumor immune evasion, and provide metastatic potential.
[Cold Spring Harbor Perspectives in Medicine]

Abstract

Macrophages and Cancer Stem Cells: A Malevolent Alliance

In view of the recent success in oncology obtained by stimulating the immune system, scientists discuss some macrophage-targeted therapeutic strategies that may also affect the CSCs and interrupt their malevolent alliance.
[Molecular Medicine]

Full Article
INDUSTRY AND POLICY NEWS

Merck Announces KEYTRUDA® (Pembrolizumab) Met Primary Endpoint of Overall Survival (OS) in Patients with Advanced Hepatocellular Carcinoma Previously Treated with Sorafenib

Merck announced that the Phase III KEYNOTE-394 trial investigating KEYTRUDA, Merck’s anti-PD-1 therapy, in Asian patients with advanced hepatocellular carcinoma previously treated with sorafenib met its primary endpoint of overall survival.
[Merck]

Press Release

Lynparza in Combination with Abiraterone Significantly Delayed Disease Progression in All-Comers in PROpel Phase III Trial in 1st-Line Metastatic Castration-Resistant Prostate Cancer

AstraZeneca and Merck announced positive high-level results from the PROpel Phase III trial.
[AstraZeneca, Inc.]

Press Release
FEATURED EVENT

Biological Assemblies: Phase Transitions

November 1 – 3, 2021
Virtual

> See All Events

JOB OPPORTUNITIES

Postdoctoral Fellow – Tumor Immunology

MD Anderson Cancer Center
– Houston, Texas, United States

University of Oxford – Colorectal Cancer

University of Oxford – Oxford, England, United Kingdom

Postdoctoral Fellow – Cancer Immunology

Weill Cornell Medicine – New York, New York, United States

Postdoctoral Associate – Skin Tumorigenesis

University of Minnesota – Austin, Minnesota, United States

Postdoctoral Fellow – Pancreatic Cancer Heterogeneity

LIRCCS Candiolo Cancer Institute – Turin, Italy

> See All Jobs

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