Cancer Stem Cell News Volume 10.38 | Sep 29 2021

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    2021-09-29 | CSCN 10.38


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.38 – 29 September, 2021
    TOP STORY

    An Enhancer-Driven Stem Cell-Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer

    Intestinal tissue from transgenic mice and patients were analyzed by histopathology and immunostaining. Human colorectal cancer cells and neoplastic murine organoids were genetically manipulated for functional studies.
    [Gastroenterology]

    AbstractGraphical Abstract
    Survey results on the insights and hurdles of CRISPR genome editing.
    PUBLICATIONSRanked by the impact factor of the journal

    SIRPα-αCD123 Fusion Antibodies Targeting CD123 in Conjunction with CD47 Blockade Enhance the Clearance of AML-Initiating Cells

    SIRPα-αCD123 antibodies were generated by fusing the extracellular domain of SIRPα to an αCD123 antibody. The binding properties of the antibodies were analyzed by flow cytometry and surface plasmon resonance.
    [Journal of Hematology & Oncology]

    Full Article

    Self-Functional Gold Nanoprobes for Intra-Nuclear Epigenomic Monitoring of Cancer Stem-Like Cells

    Investigators developed unique sub-10 nm Self-functional Gold Nanoprobes as a CSC epigenomic monitoring platform that could easily maneuver into the nucleus while not producing any conformal changes to the genomic DNA.
    [Biosensors & Bioelectronics]

    Abstract

    Adaptive Mechanoproperties Mediated by the Formin FMN1 Characterize Glioblastoma Fitness for Invasion

    Researchers identified clones of patient-derived glioma propagating cells that were either highly proliferative or highly invasive and compared their cellular architecture, migratory, and biophysical properties.
    [Developmental Cell]

    AbstractGraphical Abstract

    ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression

    Mechanistically, ALDH1A1 decreased the intracellular pH in breast cancer cells to promote phosphorylation of TAK1, activated NFκB signaling, and increased the secretion of granulocyte macrophage colony-stimulating factor, which led to myeloid-derived suppressor cell expansion and immunosuppression.
    [Cancer Research]

    Abstract

    Regulation of a Progenitor Gene Program by SOX4 Is Essential for Mammary Tumor Proliferation

    Scientists investigated the loss of SOX4 in mammary tumor development utilizing organoids derived from a PyMT genetic mouse model of breast cancer.
    [Oncogene]

    Full Article

    Tinzaparin Inhibits VL30 Retrotransposition Induced by Oxidative Stress and/or VEGF in HC11 Mouse Progenitor Mammary Cells: Association between Inhibition of Cancer Stem Cell Proliferation and Mammosphere Disaggregation

    The authors investigated the effect of tinzaparin on VL30 retrotransposition‑positive mouse HC11 mammary stem‑like epithelial cells, previously reported to be associated with induced mammosphere/CSC generation and tumorigenesis.
    [Oncology Reports]

    AbstractDownload Full Article

    Inhibition of Autophagy Mitigates Cell Migration and Invasion in Thyroid Cancer

    Autophagy was upregulated across multiple thyroid cancer subtypes. In thyroid cancer cell lines, inhibition of autophagy attenuated cancer stem cell viability, cell migration, and invasion suggesting a role for autophagy in the progression of thyroid cancer.
    [Surgery]

    Abstract

    Stereospecific Inhibition of AMPK by (R)-Crizotinib Induced Changes to the Morphology and Properties of Cancer and Cancer Stem Cell-Like Cells

    While (R)-crizotinib induced changes in morphologies or sizes of cells, (S)-crizotinib did not. Pretreatment with (R)-crizotinib suppressed the proliferation of cancer or CSC-like cells in vitro and tumor growth in vivo.
    [European Journal of Pharmacology]

    Abstract
    Explore scientific events this October with the Science Events Calendar.
    REVIEWS

    Glial and Myeloid Heterogeneity in the Brain Tumor Microenvironment

    Investigators discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma.
    [Nature Reviews Cancer]

    Abstract

    Lung Cancer Stem Cells and Their Clinical Implications

    Mouse models of lung cancer have shown that lung CSCs reside in niches that are essential for the maintenance of stemness, plasticity, enable antitumor immune evasion, and provide metastatic potential.
    [Cold Spring Harbor Perspectives in Medicine]

    Abstract

    Macrophages and Cancer Stem Cells: A Malevolent Alliance

    In view of the recent success in oncology obtained by stimulating the immune system, scientists discuss some macrophage-targeted therapeutic strategies that may also affect the CSCs and interrupt their malevolent alliance.
    [Molecular Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Merck Announces KEYTRUDA® (Pembrolizumab) Met Primary Endpoint of Overall Survival (OS) in Patients with Advanced Hepatocellular Carcinoma Previously Treated with Sorafenib

    Merck announced that the Phase III KEYNOTE-394 trial investigating KEYTRUDA, Merck’s anti-PD-1 therapy, in Asian patients with advanced hepatocellular carcinoma previously treated with sorafenib met its primary endpoint of overall survival.
    [Merck]

    Press Release

    Lynparza in Combination with Abiraterone Significantly Delayed Disease Progression in All-Comers in PROpel Phase III Trial in 1st-Line Metastatic Castration-Resistant Prostate Cancer

    AstraZeneca and Merck announced positive high-level results from the PROpel Phase III trial.
    [AstraZeneca, Inc.]

    Press Release
    FEATURED EVENT

    Biological Assemblies: Phase Transitions

    November 1 – 3, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Tumor Immunology

    MD Anderson Cancer Center
    – Houston, Texas, United States

    University of Oxford – Colorectal Cancer

    University of Oxford – Oxford, England, United Kingdom

    Postdoctoral Fellow – Cancer Immunology

    Weill Cornell Medicine – New York, New York, United States

    Postdoctoral Associate – Skin Tumorigenesis

    University of Minnesota – Austin, Minnesota, United States

    Postdoctoral Fellow – Pancreatic Cancer Heterogeneity

    LIRCCS Candiolo Cancer Institute – Turin, Italy

    > See All Jobs

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