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Vol. 10.38 – 29 September, 2021
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Intestinal tissue from transgenic mice and patients were analyzed by histopathology and immunostaining. Human colorectal cancer cells and neoplastic murine organoids were genetically manipulated for functional studies. [Gastroenterology]
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PUBLICATIONSRanked by the impact factor of the journal
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SIRPα-αCD123 antibodies were generated by fusing the extracellular domain of SIRPα to an αCD123 antibody. The binding properties of the antibodies were analyzed by flow cytometry and surface plasmon resonance.
[Journal of Hematology & Oncology]
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Investigators developed unique sub-10 nm Self-functional Gold Nanoprobes as a CSC epigenomic monitoring platform that could easily maneuver into the nucleus while not producing any conformal changes to the genomic DNA.
[Biosensors & Bioelectronics]
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Researchers identified clones of patient-derived glioma propagating cells that were either highly proliferative or highly invasive and compared their cellular architecture, migratory, and biophysical properties. [Developmental Cell]
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Mechanistically, ALDH1A1 decreased the intracellular pH in breast cancer cells to promote phosphorylation of TAK1, activated NFκB signaling, and increased the secretion of granulocyte macrophage colony-stimulating factor, which led to myeloid-derived suppressor cell expansion and immunosuppression.
[Cancer Research]
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Scientists investigated the loss of SOX4 in mammary tumor development utilizing organoids derived from a PyMT genetic mouse model of breast cancer.
[Oncogene]
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The authors investigated the effect of tinzaparin on VL30 retrotransposition‑positive mouse HC11 mammary stem‑like epithelial cells, previously reported to be associated with induced mammosphere/CSC generation and tumorigenesis. [Oncology Reports]
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Autophagy was upregulated across multiple thyroid cancer subtypes. In thyroid cancer cell lines, inhibition of autophagy attenuated cancer stem cell viability, cell migration, and invasion suggesting a role for autophagy in the progression of thyroid cancer.
[Surgery]
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While (R)-crizotinib induced changes in morphologies or sizes of cells, (S)-crizotinib did not. Pretreatment with (R)-crizotinib suppressed the proliferation of cancer or CSC-like cells in vitro and tumor growth in vivo. [European Journal of Pharmacology]
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Investigators discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma.
[Nature Reviews Cancer]
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Mouse models of lung cancer have shown that lung CSCs reside in niches that are essential for the maintenance of stemness, plasticity, enable antitumor immune evasion, and provide metastatic potential.
[Cold Spring Harbor Perspectives in Medicine]
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In view of the recent success in oncology obtained by stimulating the immune system, scientists discuss some macrophage-targeted therapeutic strategies that may also affect the CSCs and interrupt their malevolent alliance. [Molecular Medicine]
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Merck announced that the Phase III KEYNOTE-394 trial investigating KEYTRUDA, Merck’s anti-PD-1 therapy, in Asian patients with advanced hepatocellular carcinoma previously treated with sorafenib met its primary endpoint of overall survival.
[Merck]
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AstraZeneca and Merck announced positive high-level results from the PROpel Phase III trial. [AstraZeneca, Inc.]
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November 1 – 3, 2021 Virtual
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MD Anderson Cancer Center
– Houston, Texas, United States
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University of Oxford – Oxford, England, United Kingdom
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Weill Cornell Medicine – New York, New York, United States
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University of Minnesota – Austin, Minnesota, United States
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LIRCCS Candiolo Cancer Institute – Turin, Italy
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