Cancer Stem Cell News Volume 10.39 | Oct 6 2021

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    2021-10-06 | CSCN 10.39


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.39 – 6 October, 2021
    TOP STORY

    G-CSF Secreted by Mutant IDH1 Glioma Stem Cells Abolishes Myeloid Cell Immunosuppression and Enhances the Efficacy of Immunotherapy

    The authors showed that the efficacy of immune-stimulatory gene therapy was enhanced in isocitrate-dehydrogenase 1 (mIDH1) gliomas, due to the reprogramming of the myeloid cells’ compartment infiltrating the tumor microenvironment.
    [Science Advances]

    Full Article
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    PUBLICATIONSRanked by the impact factor of the journal

    HIF-1 Recruits NANOG as a Coactivator for TERT Gene Transcription in Hypoxic Breast Cancer Stem Cells

    Investigators showed that hypoxia-inducible factor 1α (HIF-1α) is required for NANOG-mediated breast CSC enrichment.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Single-Cell RNA Sequencing Reveals Cell Heterogeneity and Transcriptome Profile of Breast Cancer Lymph Node Metastasis

    Scientists identified nine cancer cell subclusters including CD44+/ALDH2+/ALDH6A1+ breast CSCs, which had a copy-number variants profile similar to that of normal breast tissue.
    [Oncogenesis]

    Full Article

    Atypical Cyclin P Regulates Cancer Cell Stemness through Activation of the WNT Pathway

    Cell line-derived spheroids, ex vivo intestinal organoid cultures and induced-pluripotent stem cells were used to investigate the role of atypical cyclin P in stemness.
    [Cellular Oncology]

    Full Article

    DCLK1-Short Splice Variant Promotes Esophageal Squamous Cell Carcinoma Progression Via the MAPK/ERK/MMP2 Pathway

    Researchers found that the expression of DCLK1 isoform 4 (DCLK1-S) was significantly increased in human esophageal squamous cell carcinoma tissues and associated with malignant progression and poor prognosis.
    [Molecular Cancer Research]

    Abstract

    Oncogenic Activity of Glucocorticoid Receptor β Is Controlled by Ubiquitination-Dependent Interaction with USP49 in Glioblastoma Cells

    By establishing a C-terminal deletion mutant, scientists determined that glucocorticoid receptor β (GRβ) can be ubiquitinated. They also found that its C-terminal was essential for this ubiquitination
    [Molecular Cancer Research]

    Abstract

    Gadd45g Initiates Embryonic Stem Cell Differentiation and Inhibits Breast Cell Carcinogenesis

    Researchers showed that the transcripts of Gadd45 family genes, including Gadd45a, Gadd45b, and Gadd45g, were gradually increased upon mouse ESC differentiation. Upregulation of Gadd45 members decreased cell proliferation and induced endodermal and trophectodermal lineages.
    [Cell Death Discovery]

    Full Article

    Exosomes Secreted by M2 Macrophages Promote Cancer Stemness of Hepatocellular Carcinoma via the miR-27a-3p/TXNIP Pathways

    Investigators explored the role of M2 exosomal miR-27a-3p in the cancer stemness of hepatocellular carcinoma via regulating thioredoxin-interacting protein (TXNIP).
    [International Immunopharmacology]

    Abstract

    SETD8 Induces Stemness and Epithelial–Mesenchymal Transition of Pancreatic Cancer Cells by Regulating ROR1 Expression

    SETD8 mediated receptor tyrosine kinase-like orphan receptor 1(ROR1) activity and regulated pancreatic cancer cells invasion and migration, although promoting the expression of stemness and epithelial–mesenchymal transition-related molecules.
    [Acta Biochimica Et Biophysica Sinica]

    Full Article

    Be sure the cells you’re gene editing are still HSPCs with StemSpan™ SFEM II culture medium.
    REVIEWS

    CRISPR Screens Guide the Way for PARP and ATR Inhibitors Biomarker Discovery

    Genome-wide CRISPR screening has emerged as a powerful tool to identify biomarkers of resistance or sensitivity to DNA repair inhibitors.
    [FEBS Journal]

    Abstract

    Poly (ADP-Ribose) Polymerase (PARP) Inhibition in Cancer: Potential Impact in Cancer Stem Cells and Therapeutic Implications

    Investigators identify key mediators and pathways in CSCs whose response to PARP inhibition is not necessarily the same as the rest of the tumor cells.
    [European Journal of Pharmacology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Henrietta Lacks Estate Sues Thermo Fisher Over HeLa Cell Line

    Attorneys representing the family of Henrietta Lacks, a Black woman whose cells were cloned, mass produced, and widely used for research after being removed from a tumor on her cervix without her knowledge in 1951, have filed a lawsuit against one of the companies that commercialized the cell line
    [The Scientist]

    Editorial

    ENHERTU® (Fam-Trastuzumab Deruxtecan-nxki) Granted Breakthrough Therapy Designation in US for Patients with HER2-Positive Metastatic Breast Cancer Treated with One or More Prior Anti-HER2-Based Regimens

    The FDA has granted ENHERTU® Breakthrough Therapy Designation in the US for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received one or more prior anti-HER2-based regimens.
    [FDA (BusinessWire, Inc.)]

    Press Release

    UC Riverside Receives $5M CIRM Grant to Train Scientists in Stem Cell Research

    The University of California, Riverside, has received a grant of $5 million from the California Institute for Regenerative Medicine, the state’s stem cell agency, to train young scientists and physicians in stem cell research.
    [University of California, Riverside]

    Press Release
    FEATURED EVENT

    Applying Fundamental Principles of Lung Biology to Respiratory Health

    November 6 – 7, 2021
    Waterville Valley, New Hampshire, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Computational Biology of Sarcomas

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Faculty Position – Hematopoiesis and Hematologic Malignancies

    The University of Kansas – Kansas City, Kansas, United States

    Postdoctoral Researcher – Tumor Metabolism in Prostate Cancer

    University of California San Francisco – San Francisco, California, United States

    Postdoctoral Fellow – Tumor Immunology

    The University of Texas – Houston, Texas, United States

    Research Assistant – Colorectal Cancer

    University of Oxford – Oxford, England, United Kingdom

    > See All Jobs

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