Cancer Stem Cell News Volume 10.39 | Oct 6 2021







2021-10-06 | CSCN 10.39


Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.39 – 6 October, 2021
TOP STORY

G-CSF Secreted by Mutant IDH1 Glioma Stem Cells Abolishes Myeloid Cell Immunosuppression and Enhances the Efficacy of Immunotherapy

The authors showed that the efficacy of immune-stimulatory gene therapy was enhanced in isocitrate-dehydrogenase 1 (mIDH1) gliomas, due to the reprogramming of the myeloid cells’ compartment infiltrating the tumor microenvironment.
[Science Advances]

Full Article
Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
PUBLICATIONSRanked by the impact factor of the journal

HIF-1 Recruits NANOG as a Coactivator for TERT Gene Transcription in Hypoxic Breast Cancer Stem Cells

Investigators showed that hypoxia-inducible factor 1α (HIF-1α) is required for NANOG-mediated breast CSC enrichment.
[Cell Reports]

Full ArticleGraphical Abstract

Single-Cell RNA Sequencing Reveals Cell Heterogeneity and Transcriptome Profile of Breast Cancer Lymph Node Metastasis

Scientists identified nine cancer cell subclusters including CD44+/ALDH2+/ALDH6A1+ breast CSCs, which had a copy-number variants profile similar to that of normal breast tissue.
[Oncogenesis]

Full Article

Atypical Cyclin P Regulates Cancer Cell Stemness through Activation of the WNT Pathway

Cell line-derived spheroids, ex vivo intestinal organoid cultures and induced-pluripotent stem cells were used to investigate the role of atypical cyclin P in stemness.
[Cellular Oncology]

Full Article

DCLK1-Short Splice Variant Promotes Esophageal Squamous Cell Carcinoma Progression Via the MAPK/ERK/MMP2 Pathway

Researchers found that the expression of DCLK1 isoform 4 (DCLK1-S) was significantly increased in human esophageal squamous cell carcinoma tissues and associated with malignant progression and poor prognosis.
[Molecular Cancer Research]

Abstract

Oncogenic Activity of Glucocorticoid Receptor β Is Controlled by Ubiquitination-Dependent Interaction with USP49 in Glioblastoma Cells

By establishing a C-terminal deletion mutant, scientists determined that glucocorticoid receptor β (GRβ) can be ubiquitinated. They also found that its C-terminal was essential for this ubiquitination
[Molecular Cancer Research]

Abstract

Gadd45g Initiates Embryonic Stem Cell Differentiation and Inhibits Breast Cell Carcinogenesis

Researchers showed that the transcripts of Gadd45 family genes, including Gadd45a, Gadd45b, and Gadd45g, were gradually increased upon mouse ESC differentiation. Upregulation of Gadd45 members decreased cell proliferation and induced endodermal and trophectodermal lineages.
[Cell Death Discovery]

Full Article

Exosomes Secreted by M2 Macrophages Promote Cancer Stemness of Hepatocellular Carcinoma via the miR-27a-3p/TXNIP Pathways

Investigators explored the role of M2 exosomal miR-27a-3p in the cancer stemness of hepatocellular carcinoma via regulating thioredoxin-interacting protein (TXNIP).
[International Immunopharmacology]

Abstract

SETD8 Induces Stemness and Epithelial–Mesenchymal Transition of Pancreatic Cancer Cells by Regulating ROR1 Expression

SETD8 mediated receptor tyrosine kinase-like orphan receptor 1(ROR1) activity and regulated pancreatic cancer cells invasion and migration, although promoting the expression of stemness and epithelial–mesenchymal transition-related molecules.
[Acta Biochimica Et Biophysica Sinica]

Full Article

Be sure the cells you’re gene editing are still HSPCs with StemSpan™ SFEM II culture medium.
REVIEWS

CRISPR Screens Guide the Way for PARP and ATR Inhibitors Biomarker Discovery

Genome-wide CRISPR screening has emerged as a powerful tool to identify biomarkers of resistance or sensitivity to DNA repair inhibitors.
[FEBS Journal]

Abstract

Poly (ADP-Ribose) Polymerase (PARP) Inhibition in Cancer: Potential Impact in Cancer Stem Cells and Therapeutic Implications

Investigators identify key mediators and pathways in CSCs whose response to PARP inhibition is not necessarily the same as the rest of the tumor cells.
[European Journal of Pharmacology]

Abstract
INDUSTRY AND POLICY NEWS

Henrietta Lacks Estate Sues Thermo Fisher Over HeLa Cell Line

Attorneys representing the family of Henrietta Lacks, a Black woman whose cells were cloned, mass produced, and widely used for research after being removed from a tumor on her cervix without her knowledge in 1951, have filed a lawsuit against one of the companies that commercialized the cell line
[The Scientist]

Editorial

ENHERTU® (Fam-Trastuzumab Deruxtecan-nxki) Granted Breakthrough Therapy Designation in US for Patients with HER2-Positive Metastatic Breast Cancer Treated with One or More Prior Anti-HER2-Based Regimens

The FDA has granted ENHERTU® Breakthrough Therapy Designation in the US for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received one or more prior anti-HER2-based regimens.
[FDA (BusinessWire, Inc.)]

Press Release

UC Riverside Receives $5M CIRM Grant to Train Scientists in Stem Cell Research

The University of California, Riverside, has received a grant of $5 million from the California Institute for Regenerative Medicine, the state’s stem cell agency, to train young scientists and physicians in stem cell research.
[University of California, Riverside]

Press Release
FEATURED EVENT

Applying Fundamental Principles of Lung Biology to Respiratory Health

November 6 – 7, 2021
Waterville Valley, New Hampshire, United States

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JOB OPPORTUNITIES

Postdoctoral Position – Computational Biology of Sarcomas

German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

Faculty Position – Hematopoiesis and Hematologic Malignancies

The University of Kansas – Kansas City, Kansas, United States

Postdoctoral Researcher – Tumor Metabolism in Prostate Cancer

University of California San Francisco – San Francisco, California, United States

Postdoctoral Fellow – Tumor Immunology

The University of Texas – Houston, Texas, United States

Research Assistant – Colorectal Cancer

University of Oxford – Oxford, England, United Kingdom

> See All Jobs

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