Cancer Stem Cell News Volume 10.40 | Oct 13 2021

2021-10-13 | CSNC 10.40

Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.40 – 13 October, 2021

Oncogenic Role of SOX9-DHCR24-Cholesterol Biosynthesis Axis in IGH-BCL2 Positive Diffuse Large B-Cell Lymphomas

Silencing of SOX9 decreased cell proliferation, induced G1/S arrest and increased apoptosis of diffuse large B-cell lymphoma cells, both in vitro and in vivo.

AbstractFull Article
Virtual Conference Exhibition: Pluripotent Stem Cells
PUBLICATIONSRanked by the impact factor of the journal

Targeting EYA2 Tyrosine Phosphatase Activity in Glioblastoma Stem Cells Induces Mitotic Catastrophe

The authors interrogated gene expression profiles from glioblastoma stem cells, differentiated glioblastoma cells, and neural stem cells, revealing EYA2 as preferentially expressed by GSCs.
[Journal of Experimental Medicine]


M6A RNA Methylation-Mediated RMRP Stability Renders Proliferation and Progression of Non-Small Cell Lung Cancer through Regulating TGFBR1/SMAD2/SMAD3 Pathway

Based on an integrative analysis of The Cancer Genome Atlas database, investigators identified long non-coding RNA-RNA Component of Mitochondrial RNA Processing Endoribonuclease (RMRP) as one of the most highly upregulated lncRNAs that awas associated with poor survival in non-small cell lung cancer.
[Cell Death & Differentiation]


CRISPR Screens Identify Cholesterol Biosynthesis as a Therapeutic Target on Stemness and Drug Resistance of Colon Cancer

To identify genetic vulnerabilities of colon cancer, scientists performed targeted CRISPR dropout screens comprising 657 Drugbank targets and 317 epigenetic regulators on two patient-derived colon CSCs-enriched spheroids.

Full Article

Circulating Cell-Free DNA Yield and Circulating-Tumor DNA Quantity from Liquid Biopsies of 12 139 Cancer Patients

Investigators examined the impact of patient age, sex, stage, and tumor type on circulating-free DNA yield, circulating-tumor DNA fraction, and estimated ctDNA quantity from a large cohort of clinical liquid biopsy samples.
[Clinical Chemistry]


Label-Free Cancer Stem-Like Cell Assay Conducted at a Single Cell Level Using Microfluidic Mechanotyping Devices

Researchers investigated the mechanical phenotype of the human colon adenocarcinoma cell, HT29, which is known to be a heterogeneous cell line with both multipotency and self-renewal abilities.
[Analytical Chemistry]

AbstractGraphical Abstract

FBXW11 Contributes to Stem-Cell-Like Features and Liver Metastasis through Regulating HIC1-Mediated SIRT1 Transcription in Colorectal Cancer

The authors explored the role of F-box and WD repeat domain containing 11 (FBXW11) in the development and metastasis of colorectal cancer (CRC). FBXW11 was overexpressed in colorectal tumor tissues and its overexpression was associated with a poor prognosis of CRC patients.
[Cell Death & Disease]

Full Article

The Polarity Protein Par3 Coordinates Positively Self-Renewal and Negatively Invasiveness in Glioblastoma

Scientists studied the role of the Par3 protein (encoded by PARD3) in glioblastoma multiforme (GBM). GBM patient transcriptomic data and patient-derived culture analysis indicated diverse levels of expression of PARD3 across and independent from subtypes.
[Cell Death & Disease]

Full Article

MYH9 Is Crucial for Stem Cell-Like Properties in Non-Small Cell Lung Cancer by Activating mTOR Signaling

Investigators found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.
[Cell Death Discovery]

Full Article
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Roles of Circadian Clocks in Cancer Pathogenesis and Treatment

Scientists discuss the roles of circadian rhythms in cancer pathogenesis, highlighting the recent advances in chronotherapeutic approaches for improved cancer treatment.
[Experimental & Molecular Medicine]

Full Article

Hypoxia Effects on Cancer Stem Cell Phenotype in Colorectal Cancer: A Mini-Review

The authors discuss CSC molecular regulation, signaling pathways, methods for the study of the topic, as well as molecules and drugs capacity of inhibiting the interplay of hypoxia-CSC.
[Molecular Biology Reports]


Emerging Roles of DLK1 in the Stem Cell Niche and Cancer Stemness

Investigators review recent evidence supporting roles for Delta-like homologue 1 (DLK1) in the maintenance of aggressive stem cell characteristics of tumor cells, specifically focusing on central nervous system tumors, neuroblastoma, and hepatocellular carcinoma.
[Journal of Histochemistry & Cytochemistry]

Full ArticleGraphical Abstract

Lixte Biotechnology Announces Collaboration with Netherlands Cancer Institute (Amsterdam) and Oncode Institute (Utrecht) to Identify the Most Promising Drug Combinations for its Lead Clinical Compound, LB-100, for Cancer Treatment

Lixte Biotechnology Holdings, Inc. announced entry into a collaboration with the Netherlands Cancer Institute, Amsterdam, and Oncode Institute, Utrecht to identify the most promising drugs to be combined with LB-100, and potentially LB-100 analogues, to be used to treat a range of cancers.
[Lixte Biotechnology Holdings, Inc.]

Press Release

Precirix Dosed First Patients in Phase I/II Clinical Study

Precirix NV announced that it has dosed the first patients in its Phase I/II clinical study of CAM-H2 for the treatment of HER2-positive metastatic cancer. The trial will evaluate CAM-H2 in HER2-positive metastatic breast and gastric/gastro-esophageal cancer patients.
[Precirix NV]

Press Release

SENC Spanish Society for Neurosciences

November 3 – 5, 2021
Lleida, Spain

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Assistant Professor – Cancer Research

University of Manitoba – Winnipeg, Manitoba, Canada

Postdoctoral Associate – Liver Cancer

Baylor College of Medicine – Houston, Texas, United States

Postdoctoral Fellow – Tumor Heterogeneity and Development of Resistant Cancer

City of Hope – Los Angeles, California, United States

Postdoctoral Fellowship – Lung Cancer

Massachusetts General Hospital – Boston, Massachusetts, United States

Postdoctoral Position – Computational Biology of Sarcomas

German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

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