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Vol. 10.40 – 13 October, 2021
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Silencing of SOX9 decreased cell proliferation, induced G1/S arrest and increased apoptosis of diffuse large B-cell lymphoma cells, both in vitro and in vivo.
[Blood]
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PUBLICATIONSRanked by the impact factor of the journal
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The authors interrogated gene expression profiles from glioblastoma stem cells, differentiated glioblastoma cells, and neural stem cells, revealing EYA2 as preferentially expressed by GSCs.
[Journal of Experimental Medicine]
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Based on an integrative analysis of The Cancer Genome Atlas database, investigators identified long non-coding RNA-RNA Component of Mitochondrial RNA Processing Endoribonuclease (RMRP) as one of the most highly upregulated lncRNAs that awas associated with poor survival in non-small cell lung cancer.
[Cell Death & Differentiation]
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To identify genetic vulnerabilities of colon cancer, scientists performed targeted CRISPR dropout screens comprising 657 Drugbank targets and 317 epigenetic regulators on two patient-derived colon CSCs-enriched spheroids.
[Oncogene]
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Investigators examined the impact of patient age, sex, stage, and tumor type on circulating-free DNA yield, circulating-tumor DNA fraction, and estimated ctDNA quantity from a large cohort of clinical liquid biopsy samples.
[Clinical Chemistry]
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Researchers investigated the mechanical phenotype of the human colon adenocarcinoma cell, HT29, which is known to be a heterogeneous cell line with both multipotency and self-renewal abilities.
[Analytical Chemistry]
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The authors explored the role of F-box and WD repeat domain containing 11 (FBXW11) in the development and metastasis of colorectal cancer (CRC). FBXW11 was overexpressed in colorectal tumor tissues and its overexpression was associated with a poor prognosis of CRC patients.
[Cell Death & Disease]
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Scientists studied the role of the Par3 protein (encoded by PARD3) in glioblastoma multiforme (GBM). GBM patient transcriptomic data and patient-derived culture analysis indicated diverse levels of expression of PARD3 across and independent from subtypes.
[Cell Death & Disease]
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Investigators found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.
[Cell Death Discovery]
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Scientists discuss the roles of circadian rhythms in cancer pathogenesis, highlighting the recent advances in chronotherapeutic approaches for improved cancer treatment.
[Experimental & Molecular Medicine]
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The authors discuss CSC molecular regulation, signaling pathways, methods for the study of the topic, as well as molecules and drugs capacity of inhibiting the interplay of hypoxia-CSC.
[Molecular Biology Reports]
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Investigators review recent evidence supporting roles for Delta-like homologue 1 (DLK1) in the maintenance of aggressive stem cell characteristics of tumor cells, specifically focusing on central nervous system tumors, neuroblastoma, and hepatocellular carcinoma.
[Journal of Histochemistry & Cytochemistry]
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Lixte Biotechnology Holdings, Inc. announced entry into a collaboration with the Netherlands Cancer Institute, Amsterdam, and Oncode Institute, Utrecht to identify the most promising drugs to be combined with LB-100, and potentially LB-100 analogues, to be used to treat a range of cancers.
[Lixte Biotechnology Holdings, Inc.]
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Precirix NV announced that it has dosed the first patients in its Phase I/II clinical study of CAM-H2 for the treatment of HER2-positive metastatic cancer. The trial will evaluate CAM-H2 in HER2-positive metastatic breast and gastric/gastro-esophageal cancer patients.
[Precirix NV]
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November 3 – 5, 2021
Lleida, Spain
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University of Manitoba – Winnipeg, Manitoba, Canada
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Baylor College of Medicine – Houston, Texas, United States
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City of Hope – Los Angeles, California, United States
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Massachusetts General Hospital – Boston, Massachusetts, United States
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German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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Umbilical & Placental Cell News