Cancer Stem Cell News Volume 10.41 | Oct 20 2021







2021-10-20 | CSCN 10.41


Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.41 – 20 October, 2021
TOP STORY

Signatures of Plasticity, Metastasis, and Immunosuppression in an Atlas of Human Small Cell Lung Cancer

Scientists sequenced 155,098 transcriptomes from 21 human biospecimens, including 54,523 small cell lung cancer (SCLC) transcriptomes. They observed greater tumor diversity in SCLC than lung adenocarcinoma, driven by canonical, intermediate, and admixed subtypes.
[Cancer Cell]

AbstractGraphical Abstract
How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU
PUBLICATIONSRanked by the impact factor of the journal

Circular RNA circIPO11 Drives Self-Renewal of Liver Cancer Initiating Cells via Hedgehog Signaling

CircIPO11 was highly expressed in hepatocellular carcinoma (HCC) tumor tissues and liver CSCs, and was required for the self-renewal maintenance of liver CSCs to initiate HCC development.
[Molecular Cancer]

Full Article

Interleukin-30 Feeds Breast Cancer Stem Cells via CXCL10 and IL23 Autocrine Loops and Shapes Immune Contexture and Host Outcome

Human and murine breast CSCs were tested for their production of and response to interleukin-30 by using flow cytometry, confocal microscopy, proliferation and sphere-formation assays, and PCR array.
[Journal For Immunotherapy of Cancer]

Abstract

Tumor Microenvironment-Based Screening Repurposes Drugs Targeting Cancer Stem Cells and Cancer-Associated Fibroblasts

Lung cancer patient-derived cancer cell and cancer-associated fibroblasts were utilized to mimic the tumor microenvironment and reproduced the stemness properties of CSCs in vitro and developed a high-throughput drug screening platform with phenotypical parameters.
[Theranostics]

Full ArticleGraphical Abstract

L1CAM Promotes Ovarian Cancer Stemness and Tumor Initiation via FGFR1/SRC/STAT3 Signaling

The genetic manipulation of L1CAM in ovarian carcinoma (OC) cells provided gain and loss-of-function models that were then employed in cell biological assays as well as in vivo tumorigenesis experiments to assess the role of L1CAM in OC cell stemness and in ovarian OSC-driven tumor initiation.
[Journal of Experimental & Clinical Cancer Research]

Full Article

Musarin, a Novel Protein with Tyrosine Kinase Inhibitory Activity from Trametes versicolor, Accepted Inhibits Colorectal Cancer Stem Cell Growth

Researchers characterized a novel 12-kDa protein that named musarin, which was purified from Trametes versicolor mushroom extract and showed significant growth inhibition on multiple human colorectal cancer cell lines in vitro.
[Biomedicine & Pharmacotherapy]

Full ArticleGraphical Abstract

Antioxidant and Antiproliferative Potential of Ethanolic Extracts from Moringa oleifera, Tropaeolum tuberosum and Annona cherimola in Colorectal Cancer Cells

The extract of A. cherimola showed the highest antioxidant activity and M. oleifera had the highest capacity to enhance the activity of detoxifying enzymes such as glutathione S-transferase and quinone oxidoreductase.
[Biomedicine & Pharmacotherapy]

Full ArticleGraphical Abstract

EGFR Is a Pivotal Player of the E2/ERβ – Mediated Functional Properties, Aggressiveness and Stemness in Triple-Negative Breast Cancer Cells

The authors reported on the epidermal growth factor receptor (EGFR)-estrogen receptor beta (ERβ) functional relationship in connection to the aggressiveness and CSC-like characteristics of triple-negative breast cancer cells.
[FEBS Journal]

Full Article

miR-3065-3p Promotes Stemness and Metastasis by Targeting CRLF1 in Colorectal Cancer

The expression of miR-3065-3p in colorectal cancer and the association of miR-3065-3p expression with prognosis of patients with colorectal cancer were analyzed using TCGA dataset or clinical cases.
[Journal of Translational Medicine]

Full Article

Gastric Cancer Stem Cells Survive in Stress Environments via Their Autophagy System

Scientists clarified the significance of autophagy systems of CSCs under stress environments. Four gastric cancer cell line were used.
[Scientific Reports]

Full Article

Synergistic Killing Effects of PD-L1-CAR T Cells and Colorectal Cancer Stem Cell-Dendritic Cell Vaccine-Sensitized T Cells in ALDH1-Positive Colorectal Cancer Stem Cells

Investigators evaluated programmed cell death ligand-1 (PD-L1) expression in colorectal CSCs (CCSCs) and non-CCSCs and designed a combination immunotherapy synchronously utilizing PD-L1-chimeric antigen receptor T (CAR)-T cells together with CCSC-dendritic cells vaccine-sensitized T cells for the treatment of colorectal cancer.
[Journal of Cancer]

Full ArticleGraphical Abstract
He needed a better model system. So he invented a new organoid. Watch James Wells' webinar.
REVIEWS

LINC00662: A New Oncogenic lncRNA with Great Potential

LINC00662 can reduce the promoter methylation level of s-adenosylmethionine-dependent hepatocellular carcinoma-promoting genes by regulating the MAT1A/SAM and AHCY/SAH axes, thereby promoting the activation of oncogenes.
[Journal of Cellular Physiology]

Abstract

Taking The Road Less Traveled – The Therapeutic Potential of CBP/β-Catenin Antagonists

Scientists discuss the challenges of targeting the Wnt signaling cascade, the safety, efficacy, and therapeutic potential of specific CBP/β-catenin antagonists and a rationale for the pleiotropic effects of CBP/β-catenin antagonists beyond Wnt signaling.
[Expert Opinion On Therapeutic Targets]

Abstract
INDUSTRY AND POLICY NEWS

Geron Announces Completion of Patient Enrollment in IMerge Phase III Clinical Trial in Lower Risk Myelodysplastic Syndromes

Geron Corporation announced the completion of patient enrollment in the IMerge Phase III clinical trial to evaluate imetelstat, a first-in-class telomerase inhibitor, in lower risk myelodysplastic syndromes.
[NGeron Corporation]

Press Release

Merck and Eisai Receive Positive EU CHMP Opinions for KEYTRUDA® (pembrolizumab) Plus LENVIMA® (Lenvatinib) in Two Different Types of Cancer

Merck announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted positive opinions recommending approval of the combination of KEYTRUDA, Merck’s anti-PD-1 therapy, plus LENVIMA.
[Merck (BusinessWire, Inc.)]

Press Release
FEATURED EVENT

American College of Toxicology Annual Meeting

November 10 – 19, 2021
Virtual

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JOB OPPORTUNITIES

Postdoctoral Scientist – Translational Cancer Biology and Therapeutics

Cedars-Sinai Medical Center – Los Angeles, California, United States

Research Assistant – Hematology/Leukemia Research

University of Cambridge – Cambridge, England, United Kingdom

Postdoctoral position – Pancreatic Adenocarcinoma

University of California Los Angeles – Los Angeles, California, United States

Postdoctoral Scientist – Skin Cancer and Aging Group

Cancer Research UK Manchester Institute – Manchester, United Kingdom

Assistant Professor – Cancer Research

University of Manitoba – Winnipeg, Manitoba, Canada

> See All Jobs

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