Cancer Stem Cell News Volume 10.42 | Oct 27 2021


    2021-10-27 | CSCN 10.42

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.42 – 27 October, 2021

    Targeting miR-126 in inv(16) Acute Myeloid Leukemia Inhibits Leukemia Development and Leukemia Stem Cell Maintenance

    The authors showed that miR-126 enhanced MYC activity through the SPRED1/PLK2-ERK-MYC axis. Genetic deletion of miR-126 significantly reduced acute myeloid leukemia rate and extended survival in CBFB-MYH11 knock-in mice.
    [Nature Communications]

    Full Article

    Scientific resources to support your stem cell research. Learn More!
    PUBLICATIONSRanked by the impact factor of the journal

    Lung Mesenchymal Stromal Cells Influenced by Th2 Cytokines Mobilize Neutrophils and Facilitate Metastasis by Producing Complement C3

    Pre-metastatic niche formation is critical for the colonization of disseminated cancer cells in distant organs. Researchers found that lung mesenchymal stromal cells at pre-metastatic stage possess potent metastasis-promoting activity.
    [Nature Communications]

    Full Article

    HOTAIR/Sp1/miR-199a Critically Regulates Cancer Stemness and Malignant Progression of Cutaneous Squamous Cell Carcinoma

    The long non-coding RNA, HOX antisense intergenic RNA (HOTAIR), is a well-characterized oncogene in multiple human cancers, but not in cutaneous squamous cell carcinoma (CSCC). Researchers investigated the potential role of HOTAIR in the stemness of CSCC.


    Reduction in O-Glycome Induces Differentially Glycosylated CD44 to Promote Stemness and Metastasis in Pancreatic Cancer

    Using several in vitro and in vivo models lacking C1GALT1 expression, investigators identified the role of aberrant O-glycosylation in stemness properties and aggressive pancreatic cancer metastasis.


    Targeting LSD1 Suppresses Stem Cell-Like Properties and Sensitizes Head and Neck Squamous Cell Carcinoma to PD-1 Blockade

    Researchers showed that high LSD1 expression was a predictor of poor prognosis for head and neck squamous cell carcinoma patients. They found that high expression of LSD1 was essential for the maintenance of the CSC properties by regulating Bmi-1 expression.
    [Cell Death & Disease]

    Full Article

    The IL-6R and BMI-1 Axis Controls Self-Renewal and Chemoresistance of Head and Neck Cancer Stem Cells

    Cancer stem-like cells drive tumorigenesis and progression of head and neck squamous cell carcinoma (HNSCC). Scientists observed that high Bmi-1 expression correlated with decreased recurrence-free survival time in HNSCC patients.
    [Cell Death & Disease]

    Full Article

    Heterogeneity of Subsets in Glioblastoma Mediated by Smad3 Palmitoylation

    Smad3 and hypoxia-inducible factor 1-alpha might be important molecular targets for treatment of glioma because they appear to coordinate the basic aspects of cancer stem cell biology.

    Full Article

    A Stem Cell Marker KLF5 Regulates CCAT1 via Three-Dimensional Genome Structure in Colorectal Cancer Cells

    Scientists explicated a regulatory mechanism of the KLF5 gene product from a view of three-dimensional genome structure in colorectal cancer.
    [British Journal of Cancer]

    Full Article

    The Regulatory Effect of Hyaluronan on Human Mesenchymal Stem Cells’ Fate Modulates Their Interaction with Cancer Cells In Vitro

    Human bone marrow-derived mesenchymal stem cells (bmMSC) contribute to the tumor microenvironment and promote cancer metastasis by inducing epithelial-to-mesenchymal transition and immune. Researchers investigated the highly disseminating breast cancer and glioblastoma multiforme cell lines to evaluate the impact of hyaluronan on tumor promoting features of bmMSC and their interaction with tumor cells.evasion.
    [Scientific Reports]

    Full Article

    CPT2 Downregulation Triggers Stemness and Oxaliplatin Resistance in Colorectal Cancer via Activating the ROS/Wnt/β-Catenin-Induced Glycolytic Metabolism

    Researchers analyzed carnitine palmitoyltransferase 2 (CPT2) expression in colorectal cancer (CRC) tissues and cells. CPT2 was overexpressed in CRC cell lines, and its effects and molecular mechanism on the proliferation, glycolysis, stemness, and oxaliplatin sensitivity were investigated.
    [Experimental Cell Research]

    AbstractGraphical Abstract

    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.

    The Emerging Roles of Gα12/13 Proteins on the Hallmarks of Cancer in Solid Tumors

    Scientists detail how Gα12/13 proteins, which were first discovered as proto-oncogenes, are known to drive several “classical” hallmarks, and also play important roles in the “emerging” hallmarks, of cancer.

    Full Article


    Context Therapeutics® and Wisconsin Oncology Network Announce First Patient Dosed in Phase II Trial of ONA-XR in Metastatic Breast Cancer

    Context Therapeutics, Inc. announced the first patient has been dosed in the Phase II Trial of Onapristone in combination with Fulvestrant for patients with ER-positive, and HER2-negative metastatic breast cancer after progression on endocrine therapy and CDK 4/6 Inhibitors.
    [Context Therapeutics, Inc.]

    Press Release

    BeyondSpring Announces First Patient Treated in Phase II Study with Plinabulin Combined with Nivolumab + Ipilimumab in Patients in 3rd Line Recurrent Small-Cell Lung Cancer Patients Who Failed Checkpoint Inhibitors

    BeyondSpring announced the first patient has been treated in an investigator-initiated, open-label Phase II study with lead asset plinabulin in combination with nivolumab + ipilimumab in patients with 3rd line recurrent small-cell lung cancer who failed checkpoint inhibitors and platinum-based chemotherapy.
    [BeyondSpring, Inc.]

    Press Release


    Cell Symposium: Overcoming Therapy Resistance in Cancer

    November 8 – 10, 2021

    > See All Events


    Postdoctoral Fellow – Ferroptosis and Metabolism in Cancer

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Scientist – Translational Cancer Biology and Therapeutics

    Cedars-Sinai Medical Center – Los Angeles, California, United States

    Postdoctoral Scientist – Skin Cancer and Aging Group

    Cancer Research UK Manchester Institute – Manchester, United Kingdom

    Postdoctoral position – Pancreatic Adenocarcinoma

    University of California Los Angeles – Los Angeles, California, United States

    Assistant Professor – Cancer Research

    University of Manitoba – Winnipeg, Manitoba, Canada

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Cancer Stem Cell News Twitter