 | | Vol. 10.42 – 27 October, 2021 |
| |
|
|
| The authors showed that miR-126 enhanced MYC activity through the SPRED1/PLK2-ERK-MYC axis. Genetic deletion of miR-126 significantly reduced acute myeloid leukemia rate and extended survival in CBFB-MYH11 knock-in mice.
[Nature Communications] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Pre-metastatic niche formation is critical for the colonization of disseminated cancer cells in distant organs. Researchers found that lung mesenchymal stromal cells at pre-metastatic stage possess potent metastasis-promoting activity.
[Nature Communications] |
|
|
|
| The long non-coding RNA, HOX antisense intergenic RNA (HOTAIR), is a well-characterized oncogene in multiple human cancers, but not in cutaneous squamous cell carcinoma (CSCC). Researchers investigated the potential role of HOTAIR in the stemness of CSCC.
[Oncogene] |
|
|
|
| Using several in vitro and in vivo models lacking C1GALT1 expression, investigators identified the role of aberrant O-glycosylation in stemness properties and aggressive pancreatic cancer metastasis.
[Oncogene] |
|
|
|
| Researchers showed that high LSD1 expression was a predictor of poor prognosis for head and neck squamous cell carcinoma patients. They found that high expression of LSD1 was essential for the maintenance of the CSC properties by regulating Bmi-1 expression.
[Cell Death & Disease] |
|
|
|
| Cancer stem-like cells drive tumorigenesis and progression of head and neck squamous cell carcinoma (HNSCC). Scientists observed that high Bmi-1 expression correlated with decreased recurrence-free survival time in HNSCC patients.
[Cell Death & Disease] |
|
|
|
| Smad3 and hypoxia-inducible factor 1-alpha might be important molecular targets for treatment of glioma because they appear to coordinate the basic aspects of cancer stem cell biology.
[Oncogenesis] |
|
|
|
| Scientists explicated a regulatory mechanism of the KLF5 gene product from a view of three-dimensional genome structure in colorectal cancer.
[British Journal of Cancer] |
|
|
|
| Human bone marrow-derived mesenchymal stem cells (bmMSC) contribute to the tumor microenvironment and promote cancer metastasis by inducing epithelial-to-mesenchymal transition and immune. Researchers investigated the highly disseminating breast cancer and glioblastoma multiforme cell lines to evaluate the impact of hyaluronan on tumor promoting features of bmMSC and their interaction with tumor cells.evasion.
[Scientific Reports] |
| | Researchers analyzed carnitine palmitoyltransferase 2 (CPT2) expression in colorectal cancer (CRC) tissues and cells. CPT2 was overexpressed in CRC cell lines, and its effects and molecular mechanism on the proliferation, glycolysis, stemness, and oxaliplatin sensitivity were investigated.
[Experimental Cell Research] |
|  |
|
|
|
| Scientists detail how Gα12/13 proteins, which were first discovered as proto-oncogenes, are known to drive several “classical” hallmarks, and also play important roles in the “emerging” hallmarks, of cancer.
[Oncogene] |
|
|
|
|
| Context Therapeutics, Inc. announced the first patient has been dosed in the Phase II Trial of Onapristone in combination with Fulvestrant for patients with ER-positive, and HER2-negative metastatic breast cancer after progression on endocrine therapy and CDK 4/6 Inhibitors.
[Context Therapeutics, Inc.] |
|
|
|
| BeyondSpring announced the first patient has been treated in an investigator-initiated, open-label Phase II study with lead asset plinabulin in combination with nivolumab + ipilimumab in patients with 3rd line recurrent small-cell lung cancer who failed checkpoint inhibitors and platinum-based chemotherapy.
[BeyondSpring, Inc.] |
|
|
|
|
| November 8 – 10, 2021
Virtual |
|
|
|
|
|
| The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
|
|
|
| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
|
|
|
| | Cancer Research UK Manchester Institute – Manchester, United Kingdom |
|
|
|
| University of California Los Angeles – Los Angeles, California, United States |
|
|
|
| | University of Manitoba – Winnipeg, Manitoba, Canada |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
