Cancer Stem Cell News Volume 10.42 | Oct 27 2021







2021-10-27 | CSCN 10.42


Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.42 – 27 October, 2021
TOP STORY

Targeting miR-126 in inv(16) Acute Myeloid Leukemia Inhibits Leukemia Development and Leukemia Stem Cell Maintenance

The authors showed that miR-126 enhanced MYC activity through the SPRED1/PLK2-ERK-MYC axis. Genetic deletion of miR-126 significantly reduced acute myeloid leukemia rate and extended survival in CBFB-MYH11 knock-in mice.
[Nature Communications]

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Lung Mesenchymal Stromal Cells Influenced by Th2 Cytokines Mobilize Neutrophils and Facilitate Metastasis by Producing Complement C3

Pre-metastatic niche formation is critical for the colonization of disseminated cancer cells in distant organs. Researchers found that lung mesenchymal stromal cells at pre-metastatic stage possess potent metastasis-promoting activity.
[Nature Communications]

Full Article

HOTAIR/Sp1/miR-199a Critically Regulates Cancer Stemness and Malignant Progression of Cutaneous Squamous Cell Carcinoma

The long non-coding RNA, HOX antisense intergenic RNA (HOTAIR), is a well-characterized oncogene in multiple human cancers, but not in cutaneous squamous cell carcinoma (CSCC). Researchers investigated the potential role of HOTAIR in the stemness of CSCC.
[Oncogene]

Abstract

Reduction in O-Glycome Induces Differentially Glycosylated CD44 to Promote Stemness and Metastasis in Pancreatic Cancer

Using several in vitro and in vivo models lacking C1GALT1 expression, investigators identified the role of aberrant O-glycosylation in stemness properties and aggressive pancreatic cancer metastasis.
[Oncogene]

Abstract

Targeting LSD1 Suppresses Stem Cell-Like Properties and Sensitizes Head and Neck Squamous Cell Carcinoma to PD-1 Blockade

Researchers showed that high LSD1 expression was a predictor of poor prognosis for head and neck squamous cell carcinoma patients. They found that high expression of LSD1 was essential for the maintenance of the CSC properties by regulating Bmi-1 expression.
[Cell Death & Disease]

Full Article

The IL-6R and BMI-1 Axis Controls Self-Renewal and Chemoresistance of Head and Neck Cancer Stem Cells

Cancer stem-like cells drive tumorigenesis and progression of head and neck squamous cell carcinoma (HNSCC). Scientists observed that high Bmi-1 expression correlated with decreased recurrence-free survival time in HNSCC patients.
[Cell Death & Disease]

Full Article

Heterogeneity of Subsets in Glioblastoma Mediated by Smad3 Palmitoylation

Smad3 and hypoxia-inducible factor 1-alpha might be important molecular targets for treatment of glioma because they appear to coordinate the basic aspects of cancer stem cell biology.
[Oncogenesis]

Full Article

A Stem Cell Marker KLF5 Regulates CCAT1 via Three-Dimensional Genome Structure in Colorectal Cancer Cells

Scientists explicated a regulatory mechanism of the KLF5 gene product from a view of three-dimensional genome structure in colorectal cancer.
[British Journal of Cancer]

Full Article

The Regulatory Effect of Hyaluronan on Human Mesenchymal Stem Cells’ Fate Modulates Their Interaction with Cancer Cells In Vitro

Human bone marrow-derived mesenchymal stem cells (bmMSC) contribute to the tumor microenvironment and promote cancer metastasis by inducing epithelial-to-mesenchymal transition and immune. Researchers investigated the highly disseminating breast cancer and glioblastoma multiforme cell lines to evaluate the impact of hyaluronan on tumor promoting features of bmMSC and their interaction with tumor cells.evasion.
[Scientific Reports]

Full Article

CPT2 Downregulation Triggers Stemness and Oxaliplatin Resistance in Colorectal Cancer via Activating the ROS/Wnt/β-Catenin-Induced Glycolytic Metabolism

Researchers analyzed carnitine palmitoyltransferase 2 (CPT2) expression in colorectal cancer (CRC) tissues and cells. CPT2 was overexpressed in CRC cell lines, and its effects and molecular mechanism on the proliferation, glycolysis, stemness, and oxaliplatin sensitivity were investigated.
[Experimental Cell Research]

AbstractGraphical Abstract

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REVIEWS

The Emerging Roles of Gα12/13 Proteins on the Hallmarks of Cancer in Solid Tumors

Scientists detail how Gα12/13 proteins, which were first discovered as proto-oncogenes, are known to drive several “classical” hallmarks, and also play important roles in the “emerging” hallmarks, of cancer.
[Oncogene]

Full Article

INDUSTRY AND POLICY NEWS

Context Therapeutics® and Wisconsin Oncology Network Announce First Patient Dosed in Phase II Trial of ONA-XR in Metastatic Breast Cancer

Context Therapeutics, Inc. announced the first patient has been dosed in the Phase II Trial of Onapristone in combination with Fulvestrant for patients with ER-positive, and HER2-negative metastatic breast cancer after progression on endocrine therapy and CDK 4/6 Inhibitors.
[Context Therapeutics, Inc.]

Press Release

BeyondSpring Announces First Patient Treated in Phase II Study with Plinabulin Combined with Nivolumab + Ipilimumab in Patients in 3rd Line Recurrent Small-Cell Lung Cancer Patients Who Failed Checkpoint Inhibitors

BeyondSpring announced the first patient has been treated in an investigator-initiated, open-label Phase II study with lead asset plinabulin in combination with nivolumab + ipilimumab in patients with 3rd line recurrent small-cell lung cancer who failed checkpoint inhibitors and platinum-based chemotherapy.
[BeyondSpring, Inc.]

Press Release

FEATURED EVENT

Cell Symposium: Overcoming Therapy Resistance in Cancer

November 8 – 10, 2021
Virtual

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JOB OPPORTUNITIES

Postdoctoral Fellow – Ferroptosis and Metabolism in Cancer

The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

Postdoctoral Scientist – Translational Cancer Biology and Therapeutics

Cedars-Sinai Medical Center – Los Angeles, California, United States

Postdoctoral Scientist – Skin Cancer and Aging Group

Cancer Research UK Manchester Institute – Manchester, United Kingdom

Postdoctoral position – Pancreatic Adenocarcinoma

University of California Los Angeles – Los Angeles, California, United States

Assistant Professor – Cancer Research

University of Manitoba – Winnipeg, Manitoba, Canada

> See All Jobs

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