Cancer Stem Cell News Volume 10.45 | Nov 17 2021


    2021-11-17 | CSCN 10.45

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.45 – 17 November, 2021

    Prognostic Significance of NT5E/CD73 in Neuroblastoma and Its Function in CSC Stemness Maintenance

    Researchers investigated the expression profile of cluster of differentiation 73 in neuroblastoma (NB), its association with NB clinical outcomes, and its influence in the regulation of CSCs stemness maintenance.
    [Cell Biology and Toxicology]


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    The IVF-Generated Human Embryonic Microenvironment Reverses Progestin Resistance in Endometrial Cancer Cells by Inducing Cancer Stem Cell Differentiation

    Scientists found that progestin resistance of endometrial CSCs could be improved or reversed by using in vitro fertilization (IVF)-generated embryonic sac-derived fluid containing the embryonic microenvironment.
    [Cancer Letters]


    Nuclear Accumulation of KPNA2 Impacts Radioresistance through Positive Regulation of the PLSCR1-STAT1 Loop in Lung Adenocarcinoma

    Researchers demonstrated that high expression of karyopherin α2 (KPNA2) was positively correlated with radioresistance and CSC properties in lung adenocarcinoma cells.
    [Cancer Science]


    Methionine Affects the Expression of Pluripotency Genes and Protein Levels Associated with Methionine Metabolism in Adult, Fetal, and Cancer Stem Cells

    Scientists revealed the differences in methionine metabolism of bone marrow-mesenchymal stem cells (MSCs), umbilical cord blood-MSCs, and CSCs, which reflected different metabolic profiles and developmental stages of stem cells.
    [Journal of Cellular Biochemistry]


    Phenotyping Clonal Populations of Glioma Stem Cell Reveals a High Degree of Plasticity in Response to Changes of Microenvironment

    Investigators used a barcode labeling approach of glioma-initiating cells to generate clonal populations over a number of passages, in combination with phenotyping using the established stem cell markers CD133, CD15, CD44, and A2B5.
    [Laboratory Investigation]

    Full Article

    Circular RNA circPIP5K1A Contributes to Cancer Stemness of Osteosarcoma by miR-515-5p/YAP Axis

    Circular RNA is a unique sort of non-coding RNAs and widely participate in the modulation of cancer progression. Researchers identified the critical function of circular RNA circPIP5K1A in stemness of osteosarcoma cells.
    [Journal of Translational Medicine]

    Full Article

    The C-Terminal HSP90 Inhibitor NCT-58 Kills Trastuzumab-Resistant Breast Cancer Stem-Like Cells

    Researchers investigated the capacity of NCT-58, a rationally-synthesized C-terminal HSP90 inhibitor, to kill trastuzumab-resistant HER2-positive breast cancer stem-like cells.
    [Cell Death Discovery]

    Full Article

    Netrin-Like Domain of sFRP4, a Wnt Antagonist Inhibits Stemness, Metastatic and Invasive Properties by Specifically Blocking MMP-2 in Cancer Stem Cells from Human Glioma Cell Line U87MG

    The authors explored the efficacy of the domains of secreted frizzled-related protein 4 (sFRP4) in inhibiting the key hallmarks of glioblastoma such as invasion, metastasis, and stemness.
    [Experimental Cell Research]


    Cellular Retinol Binding Protein-1 Inhibits Cancer Stemness via Upregulating WIF1 to Suppress Wnt/β-Catenin Pathway in Hepatocellular Carcinoma

    Researchers explored the roles and mechanisms of CRBP-1 in regulating liver cancer by using in vitro and in vivo biology approaches.
    [BMC Cancer]

    Full Article

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    Emerging Role of G9a in Cancer Stemness and Promises as a Therapeutic Target

    Scientists discuss central findings of oncogenic expression and activation of G9a in CSCs from different origins, as well as the impact of the suppression of G9a histone methyltransferase activity in such contexts.

    Full Article


    CoImmune, Inc. Announces Research Collaboration with Yeda Research and Development Company Ltd.

    CoImmune, Inc. announced a research collaboration with Yeda Research and Development Company Ltd. to evaluate the applications of the Synthetic Immune Niche technology, developed by Weizmann Institute’s researchers to enhance the expansion and function of human cytokine induced killer cells expressing chimeric antigen receptors.
    [CoImmune, Inc. (GlobeNewswire, Inc.)]

    Press Release


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    November 22 – 24, 2021

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    Postdoctoral Fellows and Research Associates – Cell and Molecular Biology

    Weill Cornell Medical College – New York, New York, United States

    Scientist – Immune System-Tumor Interactions

    Oregon Health & Science University – Portland, Oregon, United States

    Senior Researcher – Cancer Progression and Metastasis

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Fellow – Ferroptosis and Metabolism in Cancer

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Scientist – Translational Cancer Biology and Therapeutics

    Cedars-Sinai Medical Center – Los Angeles, California, United States

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