Cancer Stem Cell News Volume 10.46 | Nov 24 2021

2021-11-24 | CSCN 10.46

Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.46 – 24 November, 2021

ABHD5 Inhibits YAP-Induced C-Met Overexpression and Colon Cancer Cell Stemness via Suppressing YAP Methylation

Researchers showed that loss of ABHD5 promoted c-Met activation to sustain colorectal cancer stemness in a non-canonical manner.
[Nature Communications]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

The Sulfiredoxin-Peroxiredoxin Redox System Regulates the Stemness and Survival of Colon Cancer Stem Cells

Scientists assessed the role of the sulfiredoxin-peroxiredoxin redox system and mitochondrial oxidative phosphorylation in maintaining the stemness and survival of colon CSCs.
[Redox Biology]

Full ArticleGraphical Abstract

Autophagy Regulates the Cancer Stem Cell Phenotype of Head and Neck Squamous Cell Carcinoma through the Noncanonical FOXO3/SOX2 Axis

The mechanism by which autophagy affects the self-renewal of CSCs remains unclear. Researchers investigated whether autophagy activation contributed to CSC properties of head and neck squamous cell carcinoma.

Full Article

The IVF-Generated Human Embryonic Microenvironment Reverses Progestin Resistance in Endometrial Cancer Cells by Inducing Cancer Stem Cell Differentiation

Scientists found that progestin resistance of endometrial CSCs could be improved or reversed by using in vitro fertilization (IVF)-generated embryonic sac-derived fluid containing the embryonic microenvironment.
[Cancer Letters]


TMPRSS4 Promotes Cancer Stem–Like Properties in Prostate Cancer Cells through Upregulation of SOX2 by SLUG and TWIST1

The authors investigated whether transmembrane serine protease 4 (TMPRSS4) confered cancer stem–like properties to prostate cancer cells and characterized the underlying mechanisms.
[Journal of Experimental & Clinical Cancer Research]

Full Article

Metabolic Stress Induces GD2+ Cancer Stem Cell-Like Phenotype in Triple-Negative Breast Cancer

Researchers tested the hypothesis that metabolic stress induced breast cancer stem-like cell phenotype in triple-negative breast cancer.
[British Journal of Cancer]


Circular RNA circPIP5K1A Contributes to Cancer Stemness of Osteosarcoma by miR-515-5p/YAP Axis

Circular RNA (circRNA) is a unique sort of non-coding RNAs and widely participate in the modulation of cancer progression. Investigators identified the critical function of circRNA circPIP5K1A in stemness of osteosarcoma cells.
[Journal of Translational Medicine]

Full Article

ZRANB1 Enhances Stem-Cell-Like Features and Accelerates Tumor Progression by Regulating Sox9-Mediated USP22/Wnt/β-Catenin Pathway in Colorectal Cancer

Scientists examined the regulatory effects of tumor necrosis factor receptor-associated factor-binding protein domain (ZRANB1) on the maintenance of CSC properties and tumor growth in colorectal cancer.
[Cellular Signalling]


GLRX3, a Novel Cancer Stem Cell-Related Secretory Biomarker of Pancreatic Ductal Adenocarcinoma

Secretome analysis was performed in pancreatic CSC-enriched spheres and controlled adherent cells for biomarker discovery.
[BMC Cancer]

Full Article

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Heterogeneity of BCSCs Contributes to the Metastatic Organotropism of Breast Cancer

Scientists summarize current clinical trials, which assessed the safety and efficacy of breast cancer stem cells-related therapies.
[Journal of Experimental & Clinical Cancer Research]

Full Article


First Subject Dosed in Biosplice Therapeutics Phase Ib Clinical Trial in Oncology

Biosplice Therapeutics, Inc. announced the dosing of the first subject in a Phase Ib, open-label, multicenter, dose-escalation, dose expansion clinical trial of cirtuvivint in subjects with advanced solid tumors.
[Biosplice Therapeutics, Inc.]

Press Release


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Staff Scientist/Research Associate – Cancer Research

Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

Postdoctoral Fellows and Research Associates – Cell and Molecular Biology

Weill Cornell Medical College – New York, New York, United States

Scientist – Immune System-Tumor Interactions

Oregon Health & Science University – Portland, Oregon, United States

Senior Researcher – Cancer Progression and Metastasis

St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

Postdoctoral Fellow – Ferroptosis and Metabolism in Cancer

The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

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