 | | Vol. 10.49 – 15 December, 2021 |
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| Scientists found that lysine-specific histone demethylase 1 (LSD1) inhibition hampered the induction of the activating transcription factor 4, the master regulator of the integrated stress response.
[Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| CRISPR/Cas9 approaches were used to generate stem cell leukemia/lymphoma syndrome cells null for interleukin receptor associated kinase 1 (IRAK1) and interferon gamma which was introduced into syngeneic hosts through tail vein injection.
[Molecular Cancer] |
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| The authors performed high-dimensional flow cytometry and single-cell RNA sequencing-based immunoprofiling of murine tumor-infiltrating lymphocytes isolated from hosts bearing B16 or MC38 syngeneic tumors.
[Journal for Immunotherapy of Cancer] |
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| Scientists evaluated the in vitro effect of Manuka honey and its combination with 5-Fluorouracil, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate.
[Food Chemistry] |
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| Researchers reported that the enzyme euchromatic histone lysine methyltransferase 1 (EHMT1) was expressed in primary and relapsed Alveolar Rhabdomyosarcoma tumors.
[Journal of Pathology] |
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| Investigators characterized the function of eukaryotic translation initiation factors (eIFs) in epithelial-mesenchymal-transition (EMT) and metastasis in pancreatic cancer cells to investigate whether eIFs and downstream c-MYC affected EMT and metastasis by joint interference.
[Cancer Cell International] |
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| Researchers investigated the potential of CSC differentiation into blood cells under chemical hypoxic conditions using CoCl2. CSCs and miPS-LLCcm cells were cultured for one to seven days in the presence of CoCl2, and the expression of VEGFR1/2, Runx1, c-kit, CD31, CD34, and TER-119 was assessed.
[Scientific Reports] |
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| Investigators found that overexpression of Rec8 meiotic recombination protein (Rec8) facilitated the migration and invasion of colorectal cancer cells (CRC) in vitro and promoted the liver metastasis of CRC in vivo.
[Translational Oncology] |
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| The retinoblastoma stem-like cells were isolated by single cell cloning in combination of examination of sphere-forming capacities.
[Experimental Eye Research] |
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| Scientists elucidated the role of zinc-finger protein 750 (ZNF750) in the inhibition of the renewal ability of CSCs derived from the oral squamous cell carcinoma cell line, CAL‑27.
[Oncology Let] |
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| The authors review the current knowledge regarding circular RNA biogenesis, regulation and functions in cancer as well as their clinical potential as biomarkers, therapeutic agents and drug targets.
[Nature Reviews Clinical Oncology] |
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| Scientists summarize the current understanding of the regulatory mechanisms of T-box genes in cancer, epithelial-mesenchymal transition, and CSCs, and discuss the implications of targeting T-box genes as anticancer therapeutics.
[Journal of Cellular Biochemistry] |
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| CoImmune, Inc. announced that results from a Phase I/II clinical trial evaluating CARCIK-CD19, an investigational treatment based on the company’s chimeric antigen receptor (CAR) modified cytokine induced killer (CIK) cell platform, demonstrated sustained responses in pediatric and adult patients with B cell acute lymphoblastic leukemia who had relapsed after allogeneic hematopoietic stem cell transplantation.
[CoImmune, Inc.] |
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| January 7 – 8, 2022
Tokyo, Japan & Online |
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| Francis Crick Institute – London, England United Kingdom |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | The University of Chicago – Chicago, Illinois, United States |
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| Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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