Cancer Stem Cell News Volume 10.49 | Dec 15 2021


    2021-12-15 | CSCN 10.49

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.49 – 15 December, 2021

    LSD1-Directed Therapy Affects Glioblastoma Tumorigenicity by Deregulating the Protective ATF4-Dependent Integrated Stress Response

    Scientists found that lysine-specific histone demethylase 1 (LSD1) inhibition hampered the induction of the activating transcription factor 4, the master regulator of the integrated stress response.
    [Science Translational Medicine]


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    IRAK1-Regulated IFN-γ Signaling Induces MDSC to Facilitate Immune Evasion in FGFR1-Driven Hematological Malignancies

    CRISPR/Cas9 approaches were used to generate stem cell leukemia/lymphoma syndrome cells null for interleukin receptor associated kinase 1 (IRAK1) and interferon gamma which was introduced into syngeneic hosts through tail vein injection.
    [Molecular Cancer]

    Full Article

    Combinatorial Immunotherapy Induces Tumor-Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties

    The authors performed high-dimensional flow cytometry and single-cell RNA sequencing-based immunoprofiling of murine tumor-infiltrating lymphocytes isolated from hosts bearing B16 or MC38 syngeneic tumors.
    [Journal for Immunotherapy of Cancer]

    Full Article

    Manuka Honey in Combination with 5-Fluorouracil Decreases Physical Parameters of Colonspheres Enriched with Cancer Stem-Like Cells and Reduces Their Resistance to Apoptosis

    Scientists evaluated the in vitro effect of Manuka honey and its combination with 5-Fluorouracil, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate.
    [Food Chemistry]


    EHMT1 Promotes Tumor Progression and Maintains Stemness by Regulating ALDH1A1 Expression in Alveolar Rhabdomyosarcoma

    Researchers reported that the enzyme euchromatic histone lysine methyltransferase 1 (EHMT1) was expressed in primary and relapsed Alveolar Rhabdomyosarcoma tumors.
    [Journal of Pathology]


    Targeted Intervention of eIF4A1 Inhibits EMT and Metastasis of Pancreatic Cancer Cells via C-MYC/miR-9 Signaling

    Investigators characterized the function of eukaryotic translation initiation factors (eIFs) in epithelial-mesenchymal-transition (EMT) and metastasis in pancreatic cancer cells to investigate whether eIFs and downstream c-MYC affected EMT and metastasis by joint interference.
    [Cancer Cell International]

    Full Article

    Differentiation of Cancer Stem Cells into Erythroblasts in the Presence of CoCl2

    Researchers investigated the potential of CSC differentiation into blood cells under chemical hypoxic conditions using CoCl2. CSCs and miPS-LLCcm cells were cultured for one to seven days in the presence of CoCl2, and the expression of VEGFR1/2, Runx1, c-kit, CD31, CD34, and TER-119 was assessed.
    [Scientific Reports]

    Full Article

    REC8 Enhances Stemness and Promotes Metastasis of Colorectal Cancer through BTK/Akt/β-Catenin Signaling Pathway

    Investigators found that overexpression of Rec8 meiotic recombination protein (Rec8) facilitated the migration and invasion of colorectal cancer cells (CRC) in vitro and promoted the liver metastasis of CRC in vivo.
    [Translational Oncology]

    Full Article

    SOX2 Maintains the Stemness of Retinoblastoma Stem-Like Cells through Hippo/YAP Signaling Pathway

    The retinoblastoma stem-like cells were isolated by single cell cloning in combination of examination of sphere-forming capacities.
    [Experimental Eye Research]


    Zinc-Finger Protein 750 Mitigates Malignant Biological Behavior of Oral CSC-Like Cells Enriched from Parental CAL-27 Cells

    Scientists elucidated the role of zinc-finger protein 750 (ZNF750) in the inhibition of the renewal ability of CSCs derived from the oral squamous cell carcinoma cell line, CAL‑27.
    [Oncology Let]

    Full Article

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    The Emerging Roles of circRNAs in Cancer and Oncology

    The authors review the current knowledge regarding circular RNA biogenesis, regulation and functions in cancer as well as their clinical potential as biomarkers, therapeutic agents and drug targets.
    [Nature Reviews Clinical Oncology]


    Role of T-Box Genes in Cancer, Epithelial-Mesenchymal Transition, and Cancer Stem Cells

    Scientists summarize the current understanding of the regulatory mechanisms of T-box genes in cancer, epithelial-mesenchymal transition, and CSCs, and discuss the implications of targeting T-box genes as anticancer therapeutics.
    [Journal of Cellular Biochemistry]



    CoImmune Announces Positive Results from Phase I/II Clinical Trial of Allogeneic CAR-CIK Cells in Pediatric and Adult Patients with Acute Lymphoblastic Leukemia

    CoImmune, Inc. announced that results from a Phase I/II clinical trial evaluating CARCIK-CD19, an investigational treatment based on the company’s chimeric antigen receptor (CAR) modified cytokine induced killer (CIK) cell platform, demonstrated sustained responses in pediatric and adult patients with B cell acute lymphoblastic leukemia who had relapsed after allogeneic hematopoietic stem cell transplantation.
    [CoImmune, Inc.]

    Press Release


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    Laboratory Research Scientist – CRISPR-Based Genetic Methods

    Francis Crick Institute – London, England United Kingdom

    Clinical Research Manager – Leukemia Clinical Trials

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

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    The University of Chicago – Chicago, Illinois, United States

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    RIKEN – Hirosawam, Japan

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    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

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