 | | Vol. 11.01 – 12 January, 2022 |
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| Scientists identified Dyp-30 histone methyltransferase complex regulatory subunit (DPY30), a regulator of histone H3 lysine 4 trimethylation, as a driver of glioblastoma growth in vivo but not in vitro.
[Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified a lectin, SLBR-N, which bound to O-linked α2,3 sialic acids, that was able to enrich for CSCs in vitro and in vivo. This O-glycan was expressed on CD44 and promoted its interaction with hyaluronic acid, facilitating CD44 signaling and CSC properties.
[Science Advances] |
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| A derived quiescent CSC-specific gene expression signature was enriched in pre-formed patient glioblastoma xenograft single-cell clusters that lacked proliferative gene expression.
[Developmental Cell] |
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| The authors found that Tfap2b and a select set of target genes specified an melanocyte stem cell population at the dorsal root ganglia in zebrafish.
[Cell Reports] |
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| Scientists compared the gene expression between CD44+ and CD44− HNSCC cells and assessed the correlation of CD44 and hypoxia-inducible factor 1α expression with mouse features and outcomes of patients with head and neck squamous cell carcinomas.
[Oncogene] |
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| | Brain tissues were clinically collected from 50 patients with glioblastoma and 35 patients with acute craniocerebral injury, followed by immunohistochemical detection of the expression patterns of Forkhead box M1 (FOXM1), anterior gradient 2 (AGR2), and hypoxia-inducible factor-1α (HIF-1α). |
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[Laboratory Investigation] |
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| Investigators established a model of CSCs that was originally developed from mouse induced pluripotent stem cells (miPSCs) by proposing miPSCs to the conditioned medium of cancer derived cells, which was a mimic of carcinoma microenvironment.
[Scientific Reports] |
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| Scientists evaluated the in vitro drug release, in vitro cytotoxicity on A549 lung cancer cells, nebulization performance using next generation impactor, and the in vivo biodistribution behavior of lipid nanovesicles encapsulating rolapitant.
[European Journal of Pharmaceutical Sciences] |
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| Researchers found that zinc finger protein 267 was significantly upregulated in diffuse large B-cell lymphoma and predicted a poor survival outcome based on the bioinformatics analysis.
[Bioengineered] |
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| Investigators analyzed the expression profile of adipose tissue-derived stem cells co-cultured with cervical cancer cells through massive RNA sequencing followed by evaluation of various functional alterations resulting from the modified transcriptome.
[Blood Cancer Discovery] |
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| The authors discuss the lessons learnt from the initial trials of single-agent cytokine-based therapies and subsequent efforts to better exploit such agents for the treatment of solid tumors.
[Nature Reviews Clinical Oncology] |
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| Investigators analyzed the role of mesenchymal stem cells (MSCs) in the tumor microenvironment and summarized the relationship between MSCs and liver cancer stem cells.
[Cancer Medicine] |
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| Lixte Biotechnology Holdings, Inc. reported that its recent collaboration with the Netherlands Cancer Institute, Amsterdam, and Stichting Oncode Institute, Utrecht, has led to an initial joint patent application covering LB-100 combination therapy with one of several other investigational compounds.
[Lixte Biotechnology Holdings, Inc.] |
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| February 6 – 10, 2022
Banff, Alberta, Canada |
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| | Queen Mary University of London – London, United Kingdom |
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| Queen Mary University of London – London, United Kingdom |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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