 | | Vol. 11.02 – 19 January, 2022 |
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| Scientists discovered that programmed cell death ligand 1 (PD-L1) interacted with receptor Frizzled 6 to activate β-catenin signaling and increase β-catenin-targeted gene expression, such as a putative stem cell marker leucine-rich-repeat-containing G-protein-coupled receptor 5.
[Oncogene] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated breast cancer cell metabolism reprogramming by circular RNAs (circRNAs) from breast cancer stem cell (BCSC) exosomes and found that BCSC exosome-derived circCARM1 played an important role in breast cancer cell glycolysis.
[Oncogene] |
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| The authors identified that autophagy flux was inhibited in triple-negative breast cancer (TNBC) stem cells. miRNA-181a (miR-181a) expression is upregulated both in TNBC CSCs and patient tissues.
[Molecular Oncology] |
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| Investigators characterized a population of stem-like breast cancer cells expressing the integrin αvβ3 as transcriptionally related to activated stem/basal cells in the normal human mammary gland.
[npj Breast Cancer] |
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| The authors demonstrated that MUC1-C drives global changes in chromatin architecture in the dedifferentiation of castrate-resistant prostate cancer and triple-negative breast cancer cells.
[Molecular Cancer Research] |
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| Investigators observed that the increase of Sox9 significantly promoted hepatocellular carcinoma cell growth and invasion in cell cultures, whereas knockdown of Sox9 showed the opposite effects, suggesting that Sox9 may regulate the proliferation and invasion of hepatoma cells in an autocrine manner.
[FEBS Journal] |
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| Flow cytometry and sphere formation assays indicated that LINC01232 significantly promoted non-small cell lung carcinoma cell stemness.
[Experimental Cell Research] |
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| Researchers demonstrated that As2O3 had a remarkable inhibitory effect on tumor initiating cells of small cell lung cancer both in vitro and in vivo, and the mechanism might have involved the down-regulation of Notch pathway.
[Molecular Biology Reports] |
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| Stem cells from colorectal cancer HCT116 and CACO2 cells were isolated. TPT1-AS1 was significantly highly expressed in the CSCs compared to non-stem cells.
[Molecular Biotechnology] |
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| The authors discuss historical and recent advances in understanding cancer cell-intrinsic programmed death ligand 1 signals, mechanisms for signal controls and important immunopathologic consequences including resistance to cytotoxic agents, targeted small molecules and immunotherapies.
[Nature Reviews Cancer] |
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| Scientists summarize the current knowledge of the role of CD133 expression in gastic cancer and identify promising new strategies for treatment and management of gastric cancer.
[Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences] |
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| IMV, Inc., a clinical-stage company developing a portfolio of immune-educating therapies based on its novel DPX platform to treat solid and hematologic cancers, announced a first patient dosed in the VITALIZE Phase IIB clinical trial.
[IMV Inc.] |
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| Evaxion Biotech A/S announced it received clearance from the Australia Therapeutic Goods Administration to initiate a Phase IIb trial of its patient specific cancer immunotherapy EVX-01 in combination with Merck & Co., Inc.’s anti-PD-1 therapy KEYTRUDA®.
[Evaxion Biotech A/S] |
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| February 10 – 12, 2022
Lorne, Victoria, Australia |
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| | Luxembourg Institute of Health – Luxembourg, Luxembourg |
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| | Wayne State University School of Medicine – Detroit, Michigan, United States |
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| | Queen Mary University of London – London, England, United Kingdom |
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| Queen Mary University of London – London, England, United Kingdom |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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