Cancer Stem Cell News Volume 11.04 | Feb 2 2022


    2022-02-02 | CSCN 11.04

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.04 – 2 February, 2022

    Regulation of Reverse Electron Transfer at Mitochondrial Complex I by Unconventional Notch Action in Cancer Stem Cells

    The authors showed that reverse electron transfer through respiratory chain complex I was particularly active in brain CSCs.
    [Developmental Cell]

    Stay up-to-date with the latest stem cell research by listening to the Stem Cell Podcast!
    PUBLICATIONSRanked by the impact factor of the journal

    Nanoplatform to Investigate Tumor-Initiating Cancer Stem Cells: Breaking the Diagnostic Barrier

    Researchers developed a multimode nanoplatform to investigate tumor-initiating cancer stem cells, detected epigenetic changes, and subsequently explored their transformation signals following drug therapy.
    [ACS Applied Materials & interfaces]

    AbstractGraphical Abstract

    RNA-Binding Protein Complex LIN28/MSI2 Enhances Cancer Stem Cell-Like Properties by Modulating Hippo-YAP1 Signaling and Independently of Let-7

    Scientists revealed that Hippo signaling effector YAP1 functioned as a key downstream regulator of LIN28 to modulate the CSC-like properties and tumor progressions in triple negative breast cancer.

    Full Article

    The m6A Reading Protein YTHDF3 Potentiates Tumorigenicity of Cancer Stem-Like Cells in Ocular Melanoma through Facilitating CTNNB1 Translation

    The authors demonstrated that the N6-methyladenosine (m6A) reading protein YTHDF3 promoted the translation of the target transcript CTNNB1, contributing to ocular melanoma propagation and migration through m6A methylation.


    The Ubiquitin E3 Ligase ARIH1 Regulates hnRNP E1 Protein Stability, EMT and Breast Cancer Progression

    Investigators demonstrated that hnRNP-E1 protein stability was increased upon ARIH1 silencing, whereas, overexpression of ARIH1 leads to a reduction in hnRNP-E1.

    Full Article

    Endoplasmic Reticulum Stress Promotes Breast Cancer Cells to Release Exosomes circ_0001142 and Induces M2 Polarization of Macrophages to Regulate Tumor Progression

    Scientists screened and verified the differential expression of circ_0001142 in breast cancer tissues and cell lines through bioinformatics and qRT-PCR.
    [Pharmacological Research]

    AbstractGraphical Abstract

    MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation

    Researchers explored whether Mesenchymal stem cell- (MSC-) derived extracellular vesicles-delivered lipocalin-type prostaglandin D2 synthase (L-PGDS) could inhibit gastric cancer progression.
    [Stem Cells International]

    Full Article

    Co-Expression of Cancer Stem Cell Markers, SALL4/ALDH1A1, Is Associated with Tumor Aggressiveness and Poor Survival in Patients with Serous Ovarian Carcinoma

    The authors investigated the association between the co-expression of SALL4/ALDH1A1 proteins and clinicopathological parameters and their prognostic value in serous ovarian carcinoma patients using immunohistochemical staining on tissue microarrays.
    [Journal of Ovarian Research]

    Full Article

    Canonical WNT Pathway Inhibition Reduces ATP Synthesis Rates in Glioblastoma Stem Cells

    Researchers determined live cell metabolism and bioenergetics in pathophysiological relevant, WNT-dependent glioblastoma stem cell models.
    [Frontiers in Bioscience-Landmark]

    AbstractFull Article

    Increased Expression of PD-L1 in Endometrial Cancer Stem-Like Cells Is Regulated by Hypoxia

    Using flow cytometry and western blot assays, the authors have demonstrated that programmed cell death ligand 1 expression is higher in endometrial cancer stem-like cell derived from endometrial cancer than in nonstem-like cancer cells.
    [Frontiers in Bioscience-Landmark]

    AbstractFull Article
    Explore tools and resources for your return to the lab

    Breast Cancer Circulating Tumor Cells with Mesenchymal Features—an Unreachable Target?

    Scientists provide a comprehensive review of clinical significance of mesenchymal circulating tumor cells in breast cancer together with statistical analysis of previously published data.
    [Cellular and Molecular Life Sciences]

    Full Article

    Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications

    The authors review leukemia stem cell biology, particularly as it relates to the very heterogeneous nature of acute myeloid leukemia and to its high disease relapse rate.
    [Stem Cell Reviews and Reports]


    Lung Cancer Research Foundation and KRAS Kickers Announce Partnership

    The Lung Cancer Research Foundation (LCRF) and KRAS Kickers announced a partnership aimed at raising much needed funds for research. Together they to pledge to fund at least one two-year grant in 2022 with the goal of improving outcomes for people with KRAS-mutant lung cancer.
    [Lung Cancer Research Foundation]

    Press Release

    Panbela Initiates a Randomized, Double-Blind, Placebo-Controlled Study (ASPIRE) of Nab-Paclitaxel and Gemcitabine with or without SBP-101 in Subjects Previously Untreated for Metastatic Pancreatic Ductal Adenocarcinoma

    Panbela Therapeutics, Inc. announced the initiation of the company’s global Phase II clinical trial of SBP-101 in combination with Gemcitabine and Nab-Paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma, which is referred to as the ASPIRE trial.
    [Panbela Therapeutics, Inc.]

    Full Article

    The Australasian Society for Stem Cell Research (ASSCR) Annual Meeting

    March 9 – 11, 2022
    Melbourne, Victoria, Australia

    > See All Events


    Research Assistant – Kidney Cancer Organoids

    Knight Cancer Institute – Portland, Oregon, United States

    Postdoctoral Fellow – Cancer Immune Biomarkers

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Fellow – Lung Carcinogenesis

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Scholar – Tumor Immunology

    Moffit Cancer Center – Tampa Bay, Florida, United States

    PhD Student – Chronic Lymphocytic Leukemia

    Luxembourg Institute of Health – Luxembourg, Luxembourg

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Cancer Stem Cell News Twitter