Cancer Stem Cell News Volume 11.04 | Feb 2 2022

May 12, 2022

324

2022-02-02 | CSCN 11.04

Cancer Stem Cell News by STEMCELL Technologies

Vol. 11.04 – 2 February, 2022

TOP STORY

Regulation of Reverse Electron Transfer at Mitochondrial Complex I by Unconventional Notch Action in Cancer Stem Cells

The authors showed that reverse electron transfer through respiratory chain complex I was particularly active in brain CSCs.
[Developmental Cell]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Nanoplatform to Investigate Tumor-Initiating Cancer Stem Cells: Breaking the Diagnostic Barrier

Researchers developed a multimode nanoplatform to investigate tumor-initiating cancer stem cells, detected epigenetic changes, and subsequently explored their transformation signals following drug therapy.
[ACS Applied Materials & interfaces]

Abstract Graphical Abstract

RNA-Binding Protein Complex LIN28/MSI2 Enhances Cancer Stem Cell-Like Properties by Modulating Hippo-YAP1 Signaling and Independently of Let-7

Scientists revealed that Hippo signaling effector YAP1 functioned as a key downstream regulator of LIN28 to modulate the CSC-like properties and tumor progressions in triple negative breast cancer.
[Oncogene]

Full Article

The m⁶A Reading Protein YTHDF3 Potentiates Tumorigenicity of Cancer Stem-Like Cells in Ocular Melanoma through Facilitating CTNNB1 Translation

The authors demonstrated that the N⁶-methyladenosine (m⁶A) reading protein YTHDF3 promoted the translation of the target transcript CTNNB1, contributing to ocular melanoma propagation and migration through m⁶A methylation.
[Oncogene]

Abstract

The Ubiquitin E3 Ligase ARIH1 Regulates hnRNP E1 Protein Stability, EMT and Breast Cancer Progression

Investigators demonstrated that hnRNP-E1 protein stability was increased upon ARIH1 silencing, whereas, overexpression of ARIH1 leads to a reduction in hnRNP-E1.
[Oncogene]

Full Article

Endoplasmic Reticulum Stress Promotes Breast Cancer Cells to Release Exosomes circ_0001142 and Induces M2 Polarization of Macrophages to Regulate Tumor Progression

Scientists screened and verified the differential expression of circ_0001142 in breast cancer tissues and cell lines through bioinformatics and qRT-PCR.
[Pharmacological Research]

Abstract Graphical Abstract

MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation

Researchers explored whether Mesenchymal stem cell- (MSC-) derived extracellular vesicles-delivered lipocalin-type prostaglandin D2 synthase (L-PGDS) could inhibit gastric cancer progression.
[Stem Cells International]

Full Article

Co-Expression of Cancer Stem Cell Markers, SALL4/ALDH1A1, Is Associated with Tumor Aggressiveness and Poor Survival in Patients with Serous Ovarian Carcinoma

The authors investigated the association between the co-expression of SALL4/ALDH1A1 proteins and clinicopathological parameters and their prognostic value in serous ovarian carcinoma patients using immunohistochemical staining on tissue microarrays.
[Journal of Ovarian Research]

Full Article

Canonical WNT Pathway Inhibition Reduces ATP Synthesis Rates in Glioblastoma Stem Cells

Researchers determined live cell metabolism and bioenergetics in pathophysiological relevant, WNT-dependent glioblastoma stem cell models.
[Frontiers in Bioscience-Landmark]

Abstract Full Article

Increased Expression of PD-L1 in Endometrial Cancer Stem-Like Cells Is Regulated by Hypoxia

Using flow cytometry and western blot assays, the authors have demonstrated that programmed cell death ligand 1 expression is higher in endometrial cancer stem-like cell derived from endometrial cancer than in nonstem-like cancer cells.
[Frontiers in Bioscience-Landmark]

Abstract Full Article

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REVIEWS

Breast Cancer Circulating Tumor Cells with Mesenchymal Features—an Unreachable Target?

Scientists provide a comprehensive review of clinical significance of mesenchymal circulating tumor cells in breast cancer together with statistical analysis of previously published data.
[Cellular and Molecular Life Sciences]

Full Article

Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications

The authors review leukemia stem cell biology, particularly as it relates to the very heterogeneous nature of acute myeloid leukemia and to its high disease relapse rate.
[Stem Cell Reviews and Reports]

Abstract

INDUSTRY AND POLICY NEWS

Lung Cancer Research Foundation and KRAS Kickers Announce Partnership

The Lung Cancer Research Foundation (LCRF) and KRAS Kickers announced a partnership aimed at raising much needed funds for research. Together they to pledge to fund at least one two-year grant in 2022 with the goal of improving outcomes for people with KRAS-mutant lung cancer.
[Lung Cancer Research Foundation]

Press Release

Panbela Initiates a Randomized, Double-Blind, Placebo-Controlled Study (ASPIRE) of Nab-Paclitaxel and Gemcitabine with or without SBP-101 in Subjects Previously Untreated for Metastatic Pancreatic Ductal Adenocarcinoma

Panbela Therapeutics, Inc. announced the initiation of the company’s global Phase II clinical trial of SBP-101 in combination with Gemcitabine and Nab-Paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma, which is referred to as the ASPIRE trial.
[Panbela Therapeutics, Inc.]

Full Article

FEATURED EVENT

Regulation of Reverse Electron Transfer at Mitochondrial Complex I by Unconventional Notch Action in Cancer Stem Cells

Nanoplatform to Investigate Tumor-Initiating Cancer Stem Cells: Breaking the Diagnostic Barrier

RNA-Binding Protein Complex LIN28/MSI2 Enhances Cancer Stem Cell-Like Properties by Modulating Hippo-YAP1 Signaling and Independently of Let-7

The m⁶A Reading Protein YTHDF3 Potentiates Tumorigenicity of Cancer Stem-Like Cells in Ocular Melanoma through Facilitating CTNNB1 Translation

The Ubiquitin E3 Ligase ARIH1 Regulates hnRNP E1 Protein Stability, EMT and Breast Cancer Progression

Endoplasmic Reticulum Stress Promotes Breast Cancer Cells to Release Exosomes circ_0001142 and Induces M2 Polarization of Macrophages to Regulate Tumor Progression

MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation

Co-Expression of Cancer Stem Cell Markers, SALL4/ALDH1A1, Is Associated with Tumor Aggressiveness and Poor Survival in Patients with Serous Ovarian Carcinoma

Canonical WNT Pathway Inhibition Reduces ATP Synthesis Rates in Glioblastoma Stem Cells

Increased Expression of PD-L1 in Endometrial Cancer Stem-Like Cells Is Regulated by Hypoxia

Breast Cancer Circulating Tumor Cells with Mesenchymal Features—an Unreachable Target?

Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications

Lung Cancer Research Foundation and KRAS Kickers Announce Partnership

Panbela Initiates a Randomized, Double-Blind, Placebo-Controlled Study (ASPIRE) of Nab-Paclitaxel and Gemcitabine with or without SBP-101 in Subjects Previously Untreated for Metastatic Pancreatic Ductal Adenocarcinoma

The Australasian Society for Stem Cell Research (ASSCR) Annual Meeting

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Research Assistant – Kidney Cancer Organoids

Postdoctoral Fellow – Cancer Immune Biomarkers

Postdoctoral Fellow – Lung Carcinogenesis

Postdoctoral Scholar – Tumor Immunology

PhD Student – Chronic Lymphocytic Leukemia

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