Cancer Stem Cell News Volume 11.04 | Feb 2 2022

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    2022-02-02 | CSCN 11.04


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.04 – 2 February, 2022
    TOP STORY

    Regulation of Reverse Electron Transfer at Mitochondrial Complex I by Unconventional Notch Action in Cancer Stem Cells

    The authors showed that reverse electron transfer through respiratory chain complex I was particularly active in brain CSCs.
    [Developmental Cell]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Nanoplatform to Investigate Tumor-Initiating Cancer Stem Cells: Breaking the Diagnostic Barrier

    Researchers developed a multimode nanoplatform to investigate tumor-initiating cancer stem cells, detected epigenetic changes, and subsequently explored their transformation signals following drug therapy.
    [ACS Applied Materials & interfaces]

    AbstractGraphical Abstract

    RNA-Binding Protein Complex LIN28/MSI2 Enhances Cancer Stem Cell-Like Properties by Modulating Hippo-YAP1 Signaling and Independently of Let-7

    Scientists revealed that Hippo signaling effector YAP1 functioned as a key downstream regulator of LIN28 to modulate the CSC-like properties and tumor progressions in triple negative breast cancer.
    [Oncogene]

    Full Article

    The m6A Reading Protein YTHDF3 Potentiates Tumorigenicity of Cancer Stem-Like Cells in Ocular Melanoma through Facilitating CTNNB1 Translation

    The authors demonstrated that the N6-methyladenosine (m6A) reading protein YTHDF3 promoted the translation of the target transcript CTNNB1, contributing to ocular melanoma propagation and migration through m6A methylation.
    [Oncogene]

    Abstract

    The Ubiquitin E3 Ligase ARIH1 Regulates hnRNP E1 Protein Stability, EMT and Breast Cancer Progression

    Investigators demonstrated that hnRNP-E1 protein stability was increased upon ARIH1 silencing, whereas, overexpression of ARIH1 leads to a reduction in hnRNP-E1.
    [Oncogene]

    Full Article

    Endoplasmic Reticulum Stress Promotes Breast Cancer Cells to Release Exosomes circ_0001142 and Induces M2 Polarization of Macrophages to Regulate Tumor Progression

    Scientists screened and verified the differential expression of circ_0001142 in breast cancer tissues and cell lines through bioinformatics and qRT-PCR.
    [Pharmacological Research]

    AbstractGraphical Abstract

    MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation

    Researchers explored whether Mesenchymal stem cell- (MSC-) derived extracellular vesicles-delivered lipocalin-type prostaglandin D2 synthase (L-PGDS) could inhibit gastric cancer progression.
    [Stem Cells International]

    Full Article

    Co-Expression of Cancer Stem Cell Markers, SALL4/ALDH1A1, Is Associated with Tumor Aggressiveness and Poor Survival in Patients with Serous Ovarian Carcinoma

    The authors investigated the association between the co-expression of SALL4/ALDH1A1 proteins and clinicopathological parameters and their prognostic value in serous ovarian carcinoma patients using immunohistochemical staining on tissue microarrays.
    [Journal of Ovarian Research]

    Full Article

    Canonical WNT Pathway Inhibition Reduces ATP Synthesis Rates in Glioblastoma Stem Cells

    Researchers determined live cell metabolism and bioenergetics in pathophysiological relevant, WNT-dependent glioblastoma stem cell models.
    [Frontiers in Bioscience-Landmark]

    AbstractFull Article

    Increased Expression of PD-L1 in Endometrial Cancer Stem-Like Cells Is Regulated by Hypoxia

    Using flow cytometry and western blot assays, the authors have demonstrated that programmed cell death ligand 1 expression is higher in endometrial cancer stem-like cell derived from endometrial cancer than in nonstem-like cancer cells.
    [Frontiers in Bioscience-Landmark]

    AbstractFull Article
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    REVIEWS

    Breast Cancer Circulating Tumor Cells with Mesenchymal Features—an Unreachable Target?

    Scientists provide a comprehensive review of clinical significance of mesenchymal circulating tumor cells in breast cancer together with statistical analysis of previously published data.
    [Cellular and Molecular Life Sciences]

    Full Article

    Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications

    The authors review leukemia stem cell biology, particularly as it relates to the very heterogeneous nature of acute myeloid leukemia and to its high disease relapse rate.
    [Stem Cell Reviews and Reports]

    Abstract
    INDUSTRY AND POLICY NEWS

    Lung Cancer Research Foundation and KRAS Kickers Announce Partnership

    The Lung Cancer Research Foundation (LCRF) and KRAS Kickers announced a partnership aimed at raising much needed funds for research. Together they to pledge to fund at least one two-year grant in 2022 with the goal of improving outcomes for people with KRAS-mutant lung cancer.
    [Lung Cancer Research Foundation]

    Press Release

    Panbela Initiates a Randomized, Double-Blind, Placebo-Controlled Study (ASPIRE) of Nab-Paclitaxel and Gemcitabine with or without SBP-101 in Subjects Previously Untreated for Metastatic Pancreatic Ductal Adenocarcinoma

    Panbela Therapeutics, Inc. announced the initiation of the company’s global Phase II clinical trial of SBP-101 in combination with Gemcitabine and Nab-Paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma, which is referred to as the ASPIRE trial.
    [Panbela Therapeutics, Inc.]

    Full Article
    FEATURED EVENT

    The Australasian Society for Stem Cell Research (ASSCR) Annual Meeting

    March 9 – 11, 2022
    Melbourne, Victoria, Australia

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant – Kidney Cancer Organoids

    Knight Cancer Institute – Portland, Oregon, United States

    Postdoctoral Fellow – Cancer Immune Biomarkers

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Fellow – Lung Carcinogenesis

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Scholar – Tumor Immunology

    Moffit Cancer Center – Tampa Bay, Florida, United States

    PhD Student – Chronic Lymphocytic Leukemia

    Luxembourg Institute of Health – Luxembourg, Luxembourg

    > See All Jobs

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