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Vol. 11.07 – 23 February, 2022
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Researchers identified USP33 as essential deubiquitinase that stabilized HIF-2alpha protein in an ERK1/2-dependent manner to promote hypoxia response in cancer cells.
[EMBO Journal]
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PUBLICATIONSRanked by the impact factor of the journal
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The in vitro and in vivo results indicated that CD133+ stem cell-like cells were the main subpopulation and PARP1 was the central gene mediating oxaliplatin resistance in gastric cancer.
[Cellular and Molecular Life Sciences]
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Scientists showed that microglial morphology and functions were already impaired during glioma initiation stages.
[Glia]
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Biological and molecular alterations upon family with sequence similarity 83 member A (FAM83A) overexpression/downregulation and FAM83A’s interaction partners were investigated.
[Biomarker Research]
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All isolated analogues were screened for the cytotoxicity against intrahepatic cholangiocarcinoma cell lines of HuCCT1 and RBE through tumor colony formation and CCK-8 survival analysis.
[Bioorganic Chemistry]
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Gene knockout studies revealed that SOX2 was an essential factor for the generation of CSCs by HRASV12 in mouse and human fibroblasts.
[Scientific Reports]
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Scientists established a novel method to generate CSCs from iPSCs under a cancerous microenvironment mimicked by the conditioned medium of cancer-derived cells.
[Scientific Reports]
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Researchers sequenced the piRNAs, miRNAs and mRNAs of Piwil2-iCSCs and fibroblasts, and analyzed the differences.
[Molecular Biology Reports]
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Scientists investigated the impact of shortened telomeres in a mouse model for Barrett esophagus (L2-IL1B). The L2-IL1B mouse model was characterized by IL-1β-mediated inflammation, which led to a Barrett-like metaplasia in the transition zone between the squamous forestomach and glandular cardia/stomach.
[Oncotarget]
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The authors review the progress made in the development of CRISPR systems as a tool to study cancer, and the emerging adaptation of these technologies to improve diagnosis and treatment.
[Nature Reviews Cancer]
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Scientists summarize the major recent works on the use of antibiotics to target tumors via CSC and suggest next steps for developing this approach.
[Biochemical Pharmacology]
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Ayala Pharmaceuticals, Inc. announced that it has completed patient enrollment in Part A of the Phase II/III RINGSIDE clinical trial evaluating AL102 in desmoid tumors.
[Ayala Pharmaceuticals, Inc.]
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Baylor College of Medicine – Houston, Texas, United States
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BC Cancer Research Institute – BC Cancer Research Institute
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Florida International University – Miami, Florida, United States
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Albert Einstein College of Medicine – Bronx, New York, United States
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Moffit Cancer Center – Tampa Bay, Florida, United States
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