 | | Vol. 11.07 – 23 February, 2022 |
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| Researchers identified USP33 as essential deubiquitinase that stabilized HIF-2alpha protein in an ERK1/2-dependent manner to promote hypoxia response in cancer cells.
[EMBO Journal] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The in vitro and in vivo results indicated that CD133+ stem cell-like cells were the main subpopulation and PARP1 was the central gene mediating oxaliplatin resistance in gastric cancer.
[Cellular and Molecular Life Sciences] |
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| Scientists showed that microglial morphology and functions were already impaired during glioma initiation stages.
[Glia] |
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| Biological and molecular alterations upon family with sequence similarity 83 member A (FAM83A) overexpression/downregulation and FAM83A’s interaction partners were investigated.
[Biomarker Research] |
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| All isolated analogues were screened for the cytotoxicity against intrahepatic cholangiocarcinoma cell lines of HuCCT1 and RBE through tumor colony formation and CCK-8 survival analysis.
[Bioorganic Chemistry] |
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| Gene knockout studies revealed that SOX2 was an essential factor for the generation of CSCs by HRASV12 in mouse and human fibroblasts.
[Scientific Reports] |
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| Scientists established a novel method to generate CSCs from iPSCs under a cancerous microenvironment mimicked by the conditioned medium of cancer-derived cells.
[Scientific Reports] |
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| Researchers sequenced the piRNAs, miRNAs and mRNAs of Piwil2-iCSCs and fibroblasts, and analyzed the differences.
[Molecular Biology Reports] |
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| Scientists investigated the impact of shortened telomeres in a mouse model for Barrett esophagus (L2-IL1B). The L2-IL1B mouse model was characterized by IL-1β-mediated inflammation, which led to a Barrett-like metaplasia in the transition zone between the squamous forestomach and glandular cardia/stomach.
[Oncotarget] |
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| The authors review the progress made in the development of CRISPR systems as a tool to study cancer, and the emerging adaptation of these technologies to improve diagnosis and treatment.
[Nature Reviews Cancer] |
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| Scientists summarize the major recent works on the use of antibiotics to target tumors via CSC and suggest next steps for developing this approach.
[Biochemical Pharmacology] |
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| Ayala Pharmaceuticals, Inc. announced that it has completed patient enrollment in Part A of the Phase II/III RINGSIDE clinical trial evaluating AL102 in desmoid tumors.
[Ayala Pharmaceuticals, Inc.] |
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| Baylor College of Medicine – Houston, Texas, United States |
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| | BC Cancer Research Institute – BC Cancer Research Institute |
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| | Florida International University – Miami, Florida, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Moffit Cancer Center – Tampa Bay, Florida, United States |
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