 | Vol. 11.07 – 23 February, 2022 |
| |
|
|
| Researchers identified USP33 as essential deubiquitinase that stabilized HIF-2alpha protein in an ERK1/2-dependent manner to promote hypoxia response in cancer cells. [EMBO Journal] |
|  |
|
|
PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The in vitro and in vivo results indicated that CD133+ stem cell-like cells were the main subpopulation and PARP1 was the central gene mediating oxaliplatin resistance in gastric cancer. [Cellular and Molecular Life Sciences] |
|
|
|
| Scientists showed that microglial morphology and functions were already impaired during glioma initiation stages. [Glia] |
|
|
|
| Biological and molecular alterations upon family with sequence similarity 83 member A (FAM83A) overexpression/downregulation and FAM83A’s interaction partners were investigated. [Biomarker Research] |
|
|
|
| All isolated analogues were screened for the cytotoxicity against intrahepatic cholangiocarcinoma cell lines of HuCCT1 and RBE through tumor colony formation and CCK-8 survival analysis. [Bioorganic Chemistry] |
|
|
|
| Gene knockout studies revealed that SOX2 was an essential factor for the generation of CSCs by HRASV12 in mouse and human fibroblasts. [Scientific Reports] |
|
|
|
| Scientists established a novel method to generate CSCs from iPSCs under a cancerous microenvironment mimicked by the conditioned medium of cancer-derived cells. [Scientific Reports] |
|
|
|
| Researchers sequenced the piRNAs, miRNAs and mRNAs of Piwil2-iCSCs and fibroblasts, and analyzed the differences. [Molecular Biology Reports] |
|
|
|
| Scientists investigated the impact of shortened telomeres in a mouse model for Barrett esophagus (L2-IL1B). The L2-IL1B mouse model was characterized by IL-1β-mediated inflammation, which led to a Barrett-like metaplasia in the transition zone between the squamous forestomach and glandular cardia/stomach. [Oncotarget] |
|  |
|
|
|
| The authors review the progress made in the development of CRISPR systems as a tool to study cancer, and the emerging adaptation of these technologies to improve diagnosis and treatment. [Nature Reviews Cancer] |
|
|
|
| Scientists summarize the major recent works on the use of antibiotics to target tumors via CSC and suggest next steps for developing this approach. [Biochemical Pharmacology] |
|
|
|
|
| Ayala Pharmaceuticals, Inc. announced that it has completed patient enrollment in Part A of the Phase II/III RINGSIDE clinical trial evaluating AL102 in desmoid tumors. [Ayala Pharmaceuticals, Inc.] |
|
|
|
|
|
|
|
| Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| BC Cancer Research Institute – BC Cancer Research Institute |
|
|
|
| Florida International University – Miami, Florida, United States |
|
|
|
| Albert Einstein College of Medicine – Bronx, New York, United States |
|
|
|
| Moffit Cancer Center – Tampa Bay, Florida, United States |
|
|
|
|