Cancer Stem Cell News Volume 11.09 | Mar 9 2022

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    2022-03-09 | CSCN 11.09


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.09 – 9 March, 2022
    TOP STORY

    Ephrin-A3/EphA2 Axis Regulates Cellular Metabolic Plasticity to Enhance Cancer Stemness in Hypoxic Hepatocellular Carcinoma

    Researchers identified the Ephrin-A3/EPH Receptor A2 (EphA2) axis as a critical driver of hepatocellular carcinoma development and progression in hypoxic microenvironment.
    [Journal of Hepatology]

    Full ArticleGraphical Abstract
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    Cancer Stem Cell DNA Enabled Real-Time Genotyping with Self-Functionalized Quantum Superstructures — Overcoming the Barriers of Noninvasive cfDNA Cancer Diagnostics

    Cancer stem cell-circulating tumor DNA (ctDNA) was used to overcome the biological complexities like the inability for molecular analysis of ctDNA and dependence on ctDNA concentration rather than the molecular profile.
    [Small Methods]

    Abstract

    Combating Cancer Stem-Like Cell-Derived Resistance to Anticancer Protein by Liposome-Mediated Acclimatization Strategy

    The authors reported a liposome-mediated acclimatization strategy to overcome the CSC-emanated tumor necrosis factor-related apoptosis-inducing ligandresistance.
    [Nano Letters]

    AbstractGraphical Abstract

    Co-Targeting Leukemia-Initiating Cells and Leukemia Bulk Leads to Disease Eradication

    Researchers studied acute promyelocytic leukemia (APLs) with different leukemia-initiating cells (LICs) frequencies and investigated the effect of two HDAC inhibitors.
    [Leukemia]

    Abstract

    Activation of the Notch1-C-Myc-VCAM1 Signaling Axis Initiates Liver Progenitor Cell-Driven Hepatocarcinogenesis and Pulmonary Metastasis

    Investigators discovered that the Notch1-c-myc-VCAM1 signaling axis initiated liver progenitor cell-driven hepatocarcinogenesis and metastasis, providing a preclinical model for hepatocellular carcinoma studies.
    [Oncogene]

    Abstract

    Regulation of Cancer Stem Cell Activity by Thyroid Hormone Receptor β

    Scientists showed that thyroid hormone receptor β (TRβ) was a newly identified transcription regulator that acted to suppress CSC activity and that TRβ could be considered as a molecular target for therapeutic intervention of anaplastic thyroid cancer cells.
    [Oncogene]

    Abstract

    An Organoid Model of Colorectal Circulating Tumor Cells with Stem Cell Features, Hybrid EMT State and Distinctive Therapy Response Profile

    Investigators generated organoids from circulating tumor cells isolated from an orthotopic colorectal cancer xenograft model.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Downregulation of MUC15 by miR-183-5p.1 Promotes Liver Tumor-Initiating Cells Properties and Tumorigenesis via Regulating C-MET/PI3K/AKT/SOX2 Axis

    Researchers reported that expression of mucin 15 (MUC15) was downregulated in liver tumor-initiating cells, chemoresistance, and recurrent hepatocellular carcinoma samples.
    [Cell Death & Disease]

    Full Article

    RKIP Induction Promotes Tumor Differentiation via SOX2 Degradation in NF2-Deficient Conditions

    The authors showed that a selective Raf kinase inhibitor protein (RKIP) inducer inhibited tumor growth and promoted schwannoma cell differentiation into mature Schwann cells under NF2-deficient conditions.
    [Molecular Cancer Research]

    Full Article

    Sec23a Inhibits the Self-Renewal of Melanoma Cancer Stem Cells via Inactivation of ER-Phagy

    The stemness properties of human melaoma CSCs were confirmed in vitro by the expressions of stemness marker genes, the single-cell cloning assay and the serial spheroid formation assay.
    [Cell Communication and Signaling]

    Full Article

    FAS Receptor Regulates NOTCH Activity through ERK-JAG1 Axis Activation and Controls Oral Cancer Stemness Ability and Pulmonary Metastasis

    To determine the regulatory mechanism by which the FAS receptor exerted its oncogenic function, scientists utilized cDNA microarrays and phosphoprotein arrays to discover key candidate genes and signaling pathway regulators.
    [Cell Death Discovery]

    Full Article
    Keep current with the latest in prostate cell research.
    REVIEWS

    Circulating Tumor Cells in Precision Medicine: Challenges and Opportunities

    Investigators summarize advances in using circulating tumor cell (CTC) enumeration, characterization, and expansion to provide personalized cancer treatment and suggest future areas of study necessary to bring CTC analysis to clinics.
    [Trends in Pharmacological Sciences]

    Abstract

    Radiation Therapy Regulates TCF-1 to Maintain CD8+ T Cell Stemness and Promotes Anti-Tumor Immunotherapy

    The authors observed that high-dose radiation remarkably increased the enrichment of stem cell-like CD8+ T cells.
    [International Immunopharmacology]

    Abstract
    INDUSTRY AND POLICY NEWS

    BioNTech and Regeneron Expand Strategic Collaboration to Advance Clinical Development of FixVac and Libtayo® (Cemiplimab) Combination in NSCLC

    BioNTech SE announced the expansion of its strategic collaboration with Regeneron to advance the company’s FixVac candidate BNT116 in combination with Libtayo®, a PD-1 inhibitor, in advanced non-small cell lung cancer (NSCLC).
    [BioNTech SE]

    Press Release

    Finding Drugs for Formerly Undruggable Cancer Targets: UH Researcher Receives $2M Grant to Innovate Computer-Aided Drug Discovery for Breast Cancer

    With a $2 million recruitment grant from the Cancer Prevention and Research Institute of Texas, a University of Houston (UH) researcher will be setting up a lab to develop drugs that will work on traditionally undruggable targets in cancer.
    [University of Houston]

    Press Release
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    JOB OPPORTUNITIES

    Postdoctoral Research Scientist – Single Cell Research

    Centenary Institute – Sydney, Australia

    PhD Scientist – Oncology

    University of Virginia School of Medicine – Charlottesville, Virginia, United States

    Postdoctoral Associate – Liver Cancer

    Baylor College of Medicine – Houston, Texas, United States

    Researcher – Cancer Biology

    BC Cancer Research Institute – BC Cancer Research Institute

    Postdoctoral Associate – Immunology and Nanomedicine

    Florida International University – Miami, Florida, United States

    > See All Jobs

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