Cancer Stem Cell News Volume 11.13 | Apr 6 2022

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    2022-04-06 | CSCN 11.13


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.13 – 6 April, 2022
    TOP STORY

    Rapid and Highly Sensitive Approach for Multiplexed Somatic Fusion Detection

    Researchers identified fusions from as little as two unstained slides of FFPE tumor biopsy tissue, from circulating tumor cells collected from tumor-bearing mice, and from liquid biopsy samples from patients with known fusion-positive cancers.
    [Modern Pathology]

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    BCL6 and the Notch Pathway: A Signaling Axis Leading to a Novel Druggable Biotarget in Triple Negative Breast Cancer

    Scientists investigated signaling cascades of B cell lymphoma 6 (BCL6) in the CSC compartment of triple negative breast cancers, and the mechanisms that govern its activity, mainly through Notch signaling.
    [Cellular Oncology]

    Abstract

    Disclosing the Antitumor Potential of the Marine Bromoditerpene Sphaerococcenol A on Distinct Cancer Cellular Models

    Sphaerococcenol A capacity to impact colorectal-CSCs tumorspheres was evaluated by determining tumorspheres viability, number, and area, as well as the proteasome inhibitory activity.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Establishment and Characterization of Brain Cancer Primary Cell Cultures From Patients to Enable Phenotypic Screening for New Drugs

    Enrichment of cancer stem cells was observed in neurospheres by FACS using CD133 antibody and RT-PCR.
    [Frontiers in Pharmacology]

    Full Article

    MRI Assessment of Glutamine Uptake Correlates with the Distribution of Glutamine Transporters and Cancer Stem Cell Markers

    Using MRI, scientists determined the correlation between glutamine uptake and the distribution of glutamine transporters, namely ASCT2 and SLC38A2, glutaminase, and CSC markers, such as CD44 and CD166, in a mouse xenograft model of HT29 human colorectal cancer cells.
    [Scientific Reports]

    Full Article

    MiR-145-5p Inhibits the Proliferation of Glioma Stem Cells by Targeting Translationally Controlled Tumor Protein

    Investigators showed that miR-145-5p, a recently discovered miRNA, was expressed at low levels in primary glioma stem cells.
    [Journal of Cancer]

    Full ArticleGraphical Abstract

    MiR-222-3p Inhibits Formation of Medulloblastoma Stem-Like Cells by Targeting Notch2/C-myc Signaling Pathway

    Scientists investigated the effects of miR-222-3p on the formation of medulloblastoma stem-like cells via the Notch2/c-myc pathway.
    [Immunopharmacology and Immunotoxicology]

    Abstract

    Identification of Biomarkers Associated with Hepatocellular Carcinoma Stem Cell Characteristics Based on Co-Expression Network Analysis of Transcriptome Data and Stemness Index

    Significant genes associated hepatocellular carcinoma stemness features were screened through weighted gene co-expression network analysis and were functionally annotated using enrichment analysis.
    [Critical Reviews in Eukaryotic Gene Expression]

    Abstract

    Dynamic Detection of HER2 of Circulating Tumor Cells in Patients with Gastric Carcinoma and Its Clinical Application

    Investigators constructed and characterized human epidermal growth factor receptor 2 (HER2) lipid magnetic ball for separating circulating tumor cells in patients with gastric carcinoma.
    [Molecular Medicine Reports]

    Abstract
    Survey results on the needs and challenges in the human pluripotent stem cell field
    REVIEWS

    The Double Agents in Liquid Biopsy: Promoter and Informant Biomarkers of Early Metastases in Breast Cancer

    Scientists discuss in detail the divergence of early metastases as circulating tumor cells and the involvement of miRNAs as detectable blood-based diagnostic biomarkers that warrant a timely screening of cancer.
    [Molecular Cancer]

    Full Article

    RNA-Binding Proteins in Regulating mRNA Stability and Translation: Roles and Mechanisms in Cancer

    The authors summarize the recent advances in cancer pathological roles and mechanisms of RNA-binding proteins (RBPs) in regulating mRNA stability and translation with an emphasis on the emerging category of RNA modification-associated RBPs.
    [Seminars in Cancer Biology]

    Abstract
    INDUSTRY AND POLICY NEWS

    FDA Approves Axicabtagene Ciloleucel for Second-Line Treatment of Large B Cell Lymphoma

    The FDA approved axicabtagene ciloleucel for adult patients with large B-cell lymphoma that is refractory to first-line chemoimmunotherapy or relapses within 12 months of first-line chemoimmunotherapy.
    [US FDA]

    Press Release

    John Dick and Zulfiqar Bhutta win Canada Gairdner Awards

    Two researchers at the University of Toronto and its hospital partners – one a stem cell biologist, the other a global health researcher – have been honoured with 2022 Canada Gairdner Awards, the country’s most prestigious awards for medical and health science.
    [University of Toronto]

    Press Release
    FEATURED EVENT

    3rd Immuno-Metabolic Mechanisms of Atherosclerosis Conference

    May 1 – 5, 2022
    Riviera Maya, Mexico

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    JOB OPPORTUNITIES

    Tenure-Track Associate Professor – Stem Cell Biology

    The University of Hong Kong – Hong Kong, China

    Postdoctoral Position – Tumor Heterogeneity

    Luxembourg Institute of Health – Strassen, Luxembourg

    Postdoctoral Scientist – Translational Oncogenomics Group

    CRUK Manchester Institute – Manchester, England, United Kingdom

    Principal Scientific Researcher – Cell and Tissue Genomics

    Genentech, Inc. – South San Francisco, California, United States

    Senior Associate Scientist – Biology

    Gilead Sciences – Foster City, California, United States

    > See All Jobs

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