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Vol. 11.13 – 6 April, 2022
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Researchers identified fusions from as little as two unstained slides of FFPE tumor biopsy tissue, from circulating tumor cells collected from tumor-bearing mice, and from liquid biopsy samples from patients with known fusion-positive cancers.
[Modern Pathology]
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PUBLICATIONSRanked by the impact factor of the journal
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Scientists investigated signaling cascades of B cell lymphoma 6 (BCL6) in the CSC compartment of triple negative breast cancers, and the mechanisms that govern its activity, mainly through Notch signaling.
[Cellular Oncology]
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Sphaerococcenol A capacity to impact colorectal-CSCs tumorspheres was evaluated by determining tumorspheres viability, number, and area, as well as the proteasome inhibitory activity.
[Biomedicine & Pharmacotherapy]
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Enrichment of cancer stem cells was observed in neurospheres by FACS using CD133 antibody and RT-PCR.
[Frontiers in Pharmacology]
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Using MRI, scientists determined the correlation between glutamine uptake and the distribution of glutamine transporters, namely ASCT2 and SLC38A2, glutaminase, and CSC markers, such as CD44 and CD166, in a mouse xenograft model of HT29 human colorectal cancer cells.
[Scientific Reports]
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Investigators showed that miR-145-5p, a recently discovered miRNA, was expressed at low levels in primary glioma stem cells.
[Journal of Cancer]
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Scientists investigated the effects of miR-222-3p on the formation of medulloblastoma stem-like cells via the Notch2/c-myc pathway.
[Immunopharmacology and Immunotoxicology]
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Significant genes associated hepatocellular carcinoma stemness features were screened through weighted gene co-expression network analysis and were functionally annotated using enrichment analysis.
[Critical Reviews in Eukaryotic Gene Expression]
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Investigators constructed and characterized human epidermal growth factor receptor 2 (HER2) lipid magnetic ball for separating circulating tumor cells in patients with gastric carcinoma.
[Molecular Medicine Reports]
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Scientists discuss in detail the divergence of early metastases as circulating tumor cells and the involvement of miRNAs as detectable blood-based diagnostic biomarkers that warrant a timely screening of cancer.
[Molecular Cancer]
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The authors summarize the recent advances in cancer pathological roles and mechanisms of RNA-binding proteins (RBPs) in regulating mRNA stability and translation with an emphasis on the emerging category of RNA modification-associated RBPs.
[Seminars in Cancer Biology]
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The FDA approved axicabtagene ciloleucel for adult patients with large B-cell lymphoma that is refractory to first-line chemoimmunotherapy or relapses within 12 months of first-line chemoimmunotherapy.
[US FDA]
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Two researchers at the University of Toronto and its hospital partners – one a stem cell biologist, the other a global health researcher – have been honoured with 2022 Canada Gairdner Awards, the country’s most prestigious awards for medical and health science.
[University of Toronto]
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May 1 – 5, 2022
Riviera Maya, Mexico
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The University of Hong Kong – Hong Kong, China
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Luxembourg Institute of Health – Strassen, Luxembourg
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CRUK Manchester Institute – Manchester, England, United Kingdom
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Genentech, Inc. – South San Francisco, California, United States
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Gilead Sciences – Foster City, California, United States
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