 | | Vol. 11.30 – 10 August, 2022 |
| |
|
|
| The authors reported a cavity-injectable nanoporter-hydrogel superstructure that created glioma stem cell-specific chimeric antigen receptor (CAR) macrophages/microglia surrounding the cavity to prevent glioblastoma multiforme relapse.
[Science Translational Medicine] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists investigated the molecular heterogeneity and clinical relevance of circulating tumor-initiating cells in hepatocellular carcinoma using a novel integrated immunomagnetic-microfluidic platform.
[ACS Applied Materials & Interfaces] |
|
|
|
| Acylglycerol kinase induced CSC-like properties and was resistant to cisplatin chemotherapy in epithelial ovarian cancer cells, which were investigated through sphere formation assays and in vivo model of chemoresistance.
[Journal of Experimental & Clinical Cancer Research] |
|
|
|
| CD44 promoter activity and its interactive epithelial to mesenchymal transition-related transcription factors were evaluated by luciferase reporter assay and chromatin immunoprecipitation assay.
[Cell Death & Disease] |
|
|
|
| The authors found that treatment with a standard dose of propofol promoted glioma growth in nude mice compared with control or low-dose propofol. Propofol-treated glioma stem cells also led to larger tumor growth in nude mice than did vector-treated tumors.
[Stem Cell Research & Therapy] |
|
|
|
| Investigators reported that high mobility group box 1 (HMGB1) was overexpressed in human glioblastoma specimens. Hypoxia promoted the expression and secretion of HMGB1 in glioma stem cells.
[iScience] |
|
|
|
| It was observed that M2-tumor associated macrophages-derived exosomes promoted the stem-like properties of glioma stem cells.
[Cell Death Discovery] |
|
|
|
| MiR‑124‑3p was selected according to previous studies by the authors, and the effects of the delivery of miR‑124‑3p to glioma cells by neural stem cell‑exosomes in vitro and in vivo were evaluated.
[International Journal of Oncology] |
|
|
|
| Researchers constructed a reliable gastric cancer (GC) drug-resistant stem cell model and explored the inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du medicated serum on the drug resistance of GC stem cells based on ABC transporters.
[Chinese Medicine] |
|
|
|
| Scientists showed that bone morphogenetic protein ligands exerted potent tumor-suppressive effects against H3.3K27M and ACVR1 WT diffuse intrinsic pontine glioma in a SMAD-dependent manner.
[Nature Cancer] |
|  |
|
|
|
| The authors compile the large body of literature that has accumulated in recent years that provides evidence for the mechanisms by which FOXM1 expression promotes stemness in glioblastoma, breast, colon, ovarian, lung, hepatic, and pancreatic carcinomas.
[Seminars in Cancer Biology] |
|
|
|
| Investigators present a literature review and discussion on the differential expression of reactive and neoplastic plasmacytoid dendritic cells (pDCs), the functional role of pDCs in lymphoblastic leukemia, and the etiological association of normal pDCs and BPDCN.
[Journal of Cancer Research and Clinical Oncology] |
|
|
|
|
| Sanofi and Innovent Biologics announced a collaboration to bring innovative medicines to patients in China with difficult-to-treat cancers. This strategic partnership demonstrates Sanofi and Innovent’s commitment to bringing high quality oncology medicines to patients in China.
[Sanofi] |
|
|
|
| Rain Therapeuticsm, Inc. announced completion of enrollment in its Phase III MANTRA randomized, global, registrational trial of its lead product candidate, milademetan, an oral, small molecule inhibitor of the MDM2-p53 complex that reactivates p53.
[Rain Therapeutics, Inc.] |
|
|
|
|
| October 3 – 4, 2022
San Diego, California, United States |
|
|
|
|
|
| | NIH National Cancer Institute – Bethesda, Maryland, United States |
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | University of California, San Francisco – San Francisco, California, United States |
|
|
|
| | Columbia University – New York, New York, United States |
|
|
|
| | Essen University Hospital – Essen, Germany |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
