Cancer Stem Cell News Volume 11.30 | Aug 10 2022


    2022-08-10 | CSCN 11.31

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.30 – 10 August, 2022

    Intracavity Generation of Glioma Stem Cell–Specific CAR Macrophages Primes Locoregional Immunity for Postoperative Glioblastoma Therapy

    The authors reported a cavity-injectable nanoporter-hydrogel superstructure that created glioma stem cell-specific chimeric antigen receptor (CAR) macrophages/microglia surrounding the cavity to prevent glioblastoma multiforme relapse.
    [Science Translational Medicine]

    AbstractPress Release

    Watch the webinar where Dr. Suzan Imren discusses factors affecting the balance between HSC self-renewal and leukemic transformation
    PUBLICATIONSRanked by the impact factor of the journal

    Uncovering the Heterogeneity and Clinical Relevance of Circulating Tumor-Initiating Cells in Hepatocellular Carcinoma Using an Integrated Immunomagnetic-Microfluidic Platform

    Scientists investigated the molecular heterogeneity and clinical relevance of circulating tumor-initiating cells in hepatocellular carcinoma using a novel integrated immunomagnetic-microfluidic platform.
    [ACS Applied Materials & Interfaces]

    AbstractGraphical Abstract

    Acylglycerol Kinase Promotes Ovarian Cancer Progression and Regulates Mitochondria Function by Interacting with Ribosomal Protein L39

    Acylglycerol kinase induced CSC-like properties and was resistant to cisplatin chemotherapy in epithelial ovarian cancer cells, which were investigated through sphere formation assays and in vivo model of chemoresistance.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Gemcitabine Resistance of Pancreatic Cancer Cells Is Mediated by IGF1R Dependent Upregulation of CD44 Expression and Isoform Switching

    CD44 promoter activity and its interactive epithelial to mesenchymal transition-related transcription factors were evaluated by luciferase reporter assay and chromatin immunoprecipitation assay.
    [Cell Death & Disease]

    Full Article

    Propofol Enhances Stem-Like Properties of Glioma via GABAAR-Dependent Src Modulation of ZDHHC5-EZH2 Palmitoylation Mechanism

    The authors found that treatment with a standard dose of propofol promoted glioma growth in nude mice compared with control or low-dose propofol. Propofol-treated glioma stem cells also led to larger tumor growth in nude mice than did vector-treated tumors.
    [Stem Cell Research & Therapy]

    Full Article

    Hypoxia-Induced HMGB1 Promotes Glioma Stem Cells Self-Renewal and Tumorigenicity via RAGE

    Investigators reported that high mobility group box 1 (HMGB1) was overexpressed in human glioblastoma specimens. Hypoxia promoted the expression and secretion of HMGB1 in glioma stem cells.

    AbstractFull ArticleGraphical Abstract

    M2-Like Tumor-Associated Macrophages Transmit Exosomal miR-27b-3p and Maintain Glioblastoma Stem-Like Cell Properties

    It was observed that M2-tumor associated macrophages-derived exosomes promoted the stem-like properties of glioma stem cells.
    [Cell Death Discovery]

    Full Article

    Neural Stem Cell-Derived Exosomes Transfer miR-124-3p into Cells to Inhibit Glioma Growth by Targeting FLOT2

    MiR‑124‑3p was selected according to previous studies by the authors, and the effects of the delivery of miR‑124‑3p to glioma cells by neural stem cell‑exosomes in vitro and in vivo were evaluated.
    [International Journal of Oncology]


    The Inhibitory Effect and Mechanism of Yi-Qi-Hua-Yu-Jie-Du Decoction on the Drug Resistance of Gastric Cancer Stem Cells Based on ABC Transporters

    Researchers constructed a reliable gastric cancer (GC) drug-resistant stem cell model and explored the inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du medicated serum on the drug resistance of GC stem cells based on ABC transporters.
    [Chinese Medicine]

    Full Article

    Context-Dependent Tumor-Suppressive BMP Signaling in Diffuse Intrinsic Pontine Glioma Regulates Stemness through Epigenetic Regulation of CXXC5

    Scientists showed that bone morphogenetic protein ligands exerted potent tumor-suppressive effects against H3.3K27M and ACVR1 WT diffuse intrinsic pontine glioma in a SMAD-dependent manner.
    [Nature Cancer]

    Full Article

    Dysregulated FOXM1 Signaling in the Regulation of Cancer Stem Cells

    The authors compile the large body of literature that has accumulated in recent years that provides evidence for the mechanisms by which FOXM1 expression promotes stemness in glioblastoma, breast, colon, ovarian, lung, hepatic, and pancreatic carcinomas.
    [Seminars in Cancer Biology]

    Full Article

    Early T Cell Precursor Lymphoblastic Leukemia Accompanied by Prominent Blastic Plasmacytoid Dendritic Cell Proliferation Mimicking Blastic Plasmacytoid Dendritic Cell Neoplasm: An Exceptional Case Report and Literature Review

    Investigators present a literature review and discussion on the differential expression of reactive and neoplastic plasmacytoid dendritic cells (pDCs), the functional role of pDCs in lymphoblastic leukemia, and the etiological association of normal pDCs and BPDCN.
    [Journal of Cancer Research and Clinical Oncology]


    Sanofi and Innovent Biologics Enter Strategic Collaboration to Accelerate Development of Oncology Medicines and Expand Presence in China

    Sanofi and Innovent Biologics announced a collaboration to bring innovative medicines to patients in China with difficult-to-treat cancers. This strategic partnership demonstrates Sanofi and Innovent’s commitment to bringing high quality oncology medicines to patients in China.

    Press Release

    Rain Therapeutics Announces Completion of Enrollment in Phase III MANTRA Trial for Milademetan in Liposarcoma

    Rain Therapeuticsm, Inc. announced completion of enrollment in its Phase III MANTRA randomized, global, registrational trial of its lead product candidate, milademetan, an oral, small molecule inhibitor of the MDM2-p53 complex that reactivates p53.
    [Rain Therapeutics, Inc.]

    Press Release

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    Senior Investigator – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Faculty Positions – Center for Cancer Neuroscience

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellowship – Oncology Research in Breast Cancer Organoids

    University of California, San Francisco – San Francisco, California, United States

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    Columbia University – New York, New York, United States

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    Essen University Hospital – Essen, Germany

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