Cancer Stem Cell News Volume 11.35 | Sep 28 2022

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    2022-09-28 | CSCN 11.35


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.35 – 28 September, 2022
    TOP STORY

    A Cellular Hierarchy in Melanoma Uncouples Growth and Metastasis

    By combining mouse genetics, single-cell and spatial transcriptomics, lineage tracing, and quantitative modelling, researchers provided evidence of a hierarchical model of tumor growth that mirrored the cellular and molecular logic underlying the cell-fate specification and differentiation of the embryonic neural crest.
    [Nature]

    Abstract
    Learn about optimization of in vitro lung models in this webinar by Dr. Rachael Rayner
    PUBLICATIONSRanked by the impact factor of the journal

    Splenic Red Pulp Macrophages Provide a Niche for CML Stem Cells and Induce Therapy Resistance

    Investigators demonstrated that leukemia stem cells preferentially accumulated in the spleen and contributed to disease progression.
    [Leukemia]

    Full Article

    A Primary Hierarchically Organized Patient-Derived Model Enables in Depth Interrogation of Stemness Driven by the Coding and Non-Coding Genome

    Through classical flow sorting and functional analyses, researchers established that a single phenotypic population was highly enriched for leukemic stem cells.
    [Leukemia]

    Full Article

    A Calpain-6/YAP Axis in Sarcoma Stem Cells That Drives the Outgrowth of Tumors and Metastases

    Investigators used an osteosarcoma cell model, osteosarcoma tissues and transcriptomic data from human tumors to study gene patterns associated with calpain-6 expression or suppression.
    [Cell Death & Disease]

    Full Article

    Radiochemotherapy-Induced DNA Repair Promotes the Biogenesis of Gastric Cancer Stem Cells

    RNA-seq was performed to identify which DNA repair genes were crucial for CSC traits induction, followed by the investigation of underlying mechanism and functional significance via in vitro and in vivo experiments.
    [Stem Cell Research & Therapy]

    Full Article

    Oncofetal Protein IGF2BP1 Regulates IQGAP3 Expression To Maintain Stem Cell Potential in Cancer

    Scientists found that IGF2BP1 and IQGAP3 expression levels were highest in the blastocyst, with both decreasing during adulthood. This suggested that IQGAP3, like IGF2BP1, is an early developmental gene that is aberrantly upregulated upon re-expression of IGF2BP1 during carcinogenesis.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    β-Escin Overcomes Trastuzumab Resistance in HER2-Positive Breast Cancer by Targeting Cancer Stem-Like Features

    The effect of β-escin on trastuzumab-resistant and -sensitive cell lines in vitro was evaluated for apoptosis, expression of HER2 family members, and impact on CSC-like properties.
    [Cancer Cell International]

    Full Article

    FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A

    Researchers found that FBXW7 participated in the self-renewal, tumorigenicity, sorafenib therapy, and stem cell-like properties of hepatocellular carcinoma cells in vivo and in vitro.
    [Stem Cells International]

    Full Article

    Direct Cell–Cell Interaction Regulates Division of Stem Cells From PC-3 Human Prostate Cancer Cell Line

    Investigators found that the proliferation of PC-3-derived CSCs was significantly decreased in the presence of non-CSC-rich parental PC-3 cells compared with that in a culture in which they were absent.
    [Biochemical and Biophysical Research Communications]

    Full Article
    ON903-COVID-19 Digital Resources 728 x 90
    REVIEWS

    Functional Precision Cancer Medicine: Drug Sensitivity Screening Enabled by Cell Culture Models

    The authors provide an overview of the current state of functional precision medicine, highlight advances for drug-sensitivity screening enabled by cell culture models, and discuss how artificial intelligence can be coupled to functional precision medicine to guide patient stratification.
    [Trends in Pharmacological Sciences]

    Full Article

    The Genesis and Evolution of Acute Myeloid Leukemia Stem Cells in the Microenvironment: From Biology to Therapeutic Targeting

    Scientists discuss the relationship between leukeumic stem cells (LSCs), the bone marrow microenvironment, and how understanding the generation and evolution laws of LSCs can facilitate the development of effective therapeutic targets.
    [Cell Death Discovery]

    Full Article
    INDUSTRY AND POLICY NEWS

    AlphaFold Developers Win US$3-Million Breakthrough Prize

    Demis Hassabis and John Jumper, both at DeepMind in London, were recognized for creating the tool that has predicted the 3D structures of almost every known protein on the planet.
    [Nature News]

    Press Release

    Artiva Biotherapeutics Announces FDA Allowance of IND for AB-201, a HER2-Targeted CAR-NK for the Treatment of Solid Tumors

    Artiva Biotherapeutics, Inc. announced that the US FDA has cleared the company’s investigational new drug (IND) application for AB-201. AB-201 is an allogeneic HER2-targeted CAR NK cell therapy for the treatment of solid tumors in the outpatient setting with the option for repeat dosing.
    [Artiva Biotherapeutics, Inc.]

    Press Release
    FEATURED EVENT

    GISM Annual Meeting 2022

    October 20 – 21, 2022
    Turin, Italy

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Hematopoietic Stem Cells

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Researcher – Bioinformatics, mRNA Translation in Cancer

    Netherlands Cancer Institute (AVL) – Amsterdam, Netherlands

    Postdoctoral Research Scientist – Epithelial Plasticity and Virulence in Lung Adenocarcinoma

    CRUK Beatson Institute for Cancer Research – Glasgow, United Kingdom

    Postdoctoral Research Scientist – Bioinformatics

    Columbia University – New York, New York, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    > See All Jobs

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