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Vol. 11.35 – 28 September, 2022
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By combining mouse genetics, single-cell and spatial transcriptomics, lineage tracing, and quantitative modelling, researchers provided evidence of a hierarchical model of tumor growth that mirrored the cellular and molecular logic underlying the cell-fate specification and differentiation of the embryonic neural crest.
[Nature]
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PUBLICATIONSRanked by the impact factor of the journal
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Investigators demonstrated that leukemia stem cells preferentially accumulated in the spleen and contributed to disease progression.
[Leukemia]
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Through classical flow sorting and functional analyses, researchers established that a single phenotypic population was highly enriched for leukemic stem cells.
[Leukemia]
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Investigators used an osteosarcoma cell model, osteosarcoma tissues and transcriptomic data from human tumors to study gene patterns associated with calpain-6 expression or suppression.
[Cell Death & Disease]
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RNA-seq was performed to identify which DNA repair genes were crucial for CSC traits induction, followed by the investigation of underlying mechanism and functional significance via in vitro and in vivo experiments.
[Stem Cell Research & Therapy]
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Scientists found that IGF2BP1 and IQGAP3 expression levels were highest in the blastocyst, with both decreasing during adulthood. This suggested that IQGAP3, like IGF2BP1, is an early developmental gene that is aberrantly upregulated upon re-expression of IGF2BP1 during carcinogenesis.
[iScience]
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The effect of β-escin on trastuzumab-resistant and -sensitive cell lines in vitro was evaluated for apoptosis, expression of HER2 family members, and impact on CSC-like properties.
[Cancer Cell International]
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Researchers found that FBXW7 participated in the self-renewal, tumorigenicity, sorafenib therapy, and stem cell-like properties of hepatocellular carcinoma cells in vivo and in vitro.
[Stem Cells International]
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Investigators found that the proliferation of PC-3-derived CSCs was significantly decreased in the presence of non-CSC-rich parental PC-3 cells compared with that in a culture in which they were absent.
[Biochemical and Biophysical Research Communications]
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The authors provide an overview of the current state of functional precision medicine, highlight advances for drug-sensitivity screening enabled by cell culture models, and discuss how artificial intelligence can be coupled to functional precision medicine to guide patient stratification.
[Trends in Pharmacological Sciences]
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Scientists discuss the relationship between leukeumic stem cells (LSCs), the bone marrow microenvironment, and how understanding the generation and evolution laws of LSCs can facilitate the development of effective therapeutic targets.
[Cell Death Discovery]
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Demis Hassabis and John Jumper, both at DeepMind in London, were recognized for creating the tool that has predicted the 3D structures of almost every known protein on the planet.
[Nature News]
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Artiva Biotherapeutics, Inc. announced that the US FDA has cleared the company’s investigational new drug (IND) application for AB-201. AB-201 is an allogeneic HER2-targeted CAR NK cell therapy for the treatment of solid tumors in the outpatient setting with the option for repeat dosing.
[Artiva Biotherapeutics, Inc.]
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October 20 – 21, 2022
Turin, Italy
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Baylor College of Medicine – Houston, Texas, United States
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Netherlands Cancer Institute (AVL) – Amsterdam, Netherlands
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CRUK Beatson Institute for Cancer Research – Glasgow, United Kingdom
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Columbia University – New York, New York, United States
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Cedars-Sinai – Los Angeles, California, United States
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Umbilical & Placental Cell News