Cancer Stem Cell News Volume 11.39 | Oct 26 2022

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    2022-10-26 | CSCN 11.39


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.39 – 26 October, 2022
    TOP STORY

    A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia

    Researchers provided biochemical, genetic, and functional evidence that dynamics in ribosomal RNA (rRNA) 2′-O-methylation regulated leukemia stem cell activity in vivo.
    [Cancer Discovery]

    Abstract
    Survey results on the needs and challenges in the human pluripotent stem cell field
    PUBLICATIONSRanked by the impact factor of the journal

    Targeting Breast and Pancreatic Cancer Metastasis Using a Dual-Cadherin Antibody

    Scientists showed that an antibody against cadherin proteins effectively suppressed blood-borne metastasis in mouse isogenic and xenograft models of triple-negative breast and pancreatic cancers.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full ArticlePress Release

    The NQO1/p53/SREBP1 Axis Promotes Hepatocellular Carcinoma Progression and Metastasis by Regulating Snail Stability

    Bioinformatics analysis and immunohistochemical results showed that NQO1 was highly expressed in hepatocellular carcinoma (HCC) tissues. Overexpression of NQO1 promoted cell proliferation, epithelial-to-mesenchymal transition process, and angiogenesis of HCC cells.
    [Oncogene]

    Abstract

    Integrin Regulation by Tissue Factor Promotes Cancer Stemness and Metastatic Dissemination in Breast Cancer

    The authors showed an association between tissue factor expression and metastasis as well as cancer stemness in 574 breast cancer patients.
    [Oncogene]

    Abstract

    CircLRFN5 Inhibits the Progression of Glioblastoma via PRRX2/GCH1 Mediated Ferroptosis

    CircLRFN5 overexpression inhibited the cell viabilities, proliferation, neurosphere formation, stemness, and tumorigenesis of glioma stem cells via inducing ferroptosis.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Clinical Implications of Circulating Tumor DNA in Predicting the Outcome of Diffuse Large B Cell Lymphoma Patients Receiving First-Line Therapy

    Using a lymphoma-specific sequencing panel, investigators assessed the prognostic and predictive utilities of circulating tumor DNA measurements before, during, and after first-line therapy.
    [BMC Medicine]

    Full Article

    FBXO31 Sentisizes CSC-Like Cells to Cisplatin by Promoting Ferroptosis and Facilitating Proteasomal Degradation of GPX4 in CCA

    Functional studies showed FBXO31 inhibited cell growth, migration, invasion, CSC properties, and epithelial-mesenchymal transition in vitro and impeded tumor growth in vivo.
    [Liver International]

    Abstract

    Long Non-Coding RNA HOTAIR Regulates the Stemness of Breast Cancer Cells via Activation of the NF-κB Signaling Pathway

    Scientists found that the long noncoding RNA HOTAIR was highly expressed in breast CSCs. HOTAIR was required for breast CSC self-renewal and tumor propagation.
    [Journal of Biological Chemistry]

    Full Article

    Noxa and Mcl-1 Expression Influence the Sensitivity to BH3-Mimetics That Target Bcl-xL in Patient-Derived Glioma Stem Cells

    Researchers determined that the most abundantly expressed anti-apoptotic Bcl-2 family members, Bcl-xL and Mcl-1, were the most relevant in regulating patient-derived glioma stem cell survival.
    [Scientific Reports]

    Full Article

    RELA Is Required for CD271 Expression and Stem-Like Characteristics in Hypopharyngeal Cancer

    Investigators screened transcription factors and found that RELA, a subunit of nuclear factor kappaB, was critical for CD271 transcription in cancer cells.
    [Scientific Reports]

    Full Article
    Survey results on the insights and hurdles of CRISPR genome editing.
    REVIEWS

    Practical Considerations for the Use of Circulating Tumor DNA in the Treatment of Patients with Cancer

    Scientists present a practical overview for the selection of the most appropriate liquid biopsy assay, specifically focusing on circulating tumor DNA and how it may affect patient treatment and case management across multiple tumor types.
    [JAMA Oncology]

    Abstract

    The Role of Exosomes in the Molecular Mechanisms of Metastasis: Focusing on EMT and Cancer Stem Cells

    The authors discuss the effect of exosomes on signaling pathways associated with epithelial-mesenchymal transition (EMT) and CSCs, as well as possible therapeutic strategies of exosomes in cancer metastasis.
    [Life Sciences]

    Abstract
    INDUSTRY AND POLICY NEWS

    BriaCell Announces Successful Completion of Phase I Portion of Clinical Study in Advanced Breast Cancer; Randomized Phase II Efficacy Evaluation Progressing

    BriaCell Therapeutics Corp. announced the completion of the Phase I part of the clinical trial of its lead candidate, Bria-IMT™, in combination with Incyte’s PD-1 inhibitor, retifanlimab, in advanced breast cancer.
    [BriaCell Therapeutics Corp.]

    Press Release

    Bio-Path Holdings Announces First Patient Dosed in Phase I/Ib Study of BP1002 in Refractory/Relapsed Acute Myeloid Leukemia Patients

    Bio-Path Holdings, Inc. announced the enrollment and dosing of the first patient in a Phase I/Ib clinical trial evaluating the ability of BP1002 to treat refractory/relapsed acute myeloid leukemia patients.
    [Bio-Path Holdings, Inc.]

    Press Release
    FEATURED EVENT

    EHA-SWG Scientific Meeting on Integrated Cell Tracking in Oncohematology

    November 10 – 12, 2022
    Bordeaux, France

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Scientist – Genitourinary Development

    Columbia University Irving Medical Center – New York, New York, United States

    Postdoctoral Position – Advanced Tumoroid Biology

    Ludwig Maximilians University of Munich – Munich, Germany

    Postdoctoral Position – Computational Biology

    Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States

    Senior Bioinformaticians – Skin Cancer Research

    Wellcome Genome Campus – Saffron Walden, England, United Kingdom

    Postdoctoral Fellow – Micro-Sampling and Biomarkers

    AstraZeneca – Gothenburg, Sweden

    > See All Jobs

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