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Vol. 11.45 – 14 December, 2022
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Researchers identified nuclear prelamin A recognition factor (NARF) as a hypoxia-inducible, hypoxia-inducible factor 1 target gene in human breast cancer cells.
[Science Advances]
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PUBLICATIONSRanked by the impact factor of the journal
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The authors identified binding targets of Musashi-1 in normal neural and group 3 medulloblastoma stem cells and then cross referenced these data with unbiased large-scale screens at the transcriptomic, translatomic, and proteomic levels.
[Nature Communications]
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Investigators showed that Hoxa9/Meis1-dependent AML was hierarchically organized and tracked the developmental potential of leukemic stem cell phenotypes.
[Leukemia]
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Scientists demonstrated that the F-box protein FBXL2 was a critical negative regulator of breast cancer stem cell stemness and that downregulation of FBXL2 played a causal role in TNBC drug resistance.
[Oncogene]
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Researchers clarified a new oncogenic mechanism of enhancer of Zeste Homolog 2 (EZH2) by which it interacted with heterochromatin protein 1 binding protein 3 (HP1BP3) and epigenetically activated WNT7B thereby promoting TMZ resistance in glioma stem cells.
[Oncogene]
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To characterize protein expression in glioblastoma CSCs (GSCs), scientists performed in-depth proteogenomic analysis of patient-derived GSCs by RNA-sequencing and mass-spectrometry.
[Molecular Oncology]
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The authors established two highly malignant glioma stem-like cell (GSC) lines from clinical surgical specimens and found that the long non-coding RNA growth arrest-specific 5 (GAS5) expression was downregulated in GSCs and high-grade glioma tissues.
[Cancer Gene Therapy]
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Based on the cytotoxic properties of aporphine compounds, researchers evaluated the biological effect of 12 compounds obtained through total synthesis of (±)-apomorphine hydrochloride against glioblastoma cells.
[Scientific Reports]
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Scientists reported that triiodothyronine exerted significant impact on CSCs of two colorectal cancer cell lines cultured in the form of colonospheres.
[Oncology Reports]
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Investigators identified a role for Twist-related protein 1 (TWIST1) in the establishment of esophageal squamous cell carcinoma CSC-like phenotype, facilitating the transformation of non-CSCs to CSCs.
[BMC Cancer]
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Scientists review the progress made in understanding biological features of circulating tumor cells and provide insight into exploiting these developments to design future clinical tools
[Nature Reviews Cancer]
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The authors discuss CSCs, radioresistance-mediated CSCs development, epithelial-to-mesenchymal transition associated with CSCs, the role of exosomes in radioresistance development, and the current state of radiation therapy.
[Biomarkers]
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Calidi Biotherapeutics, Inc. announced that the CIRM has awarded the company a $3.1 million grant to support the continued development of the company’s Supernova-1 pre-clinical program through an Investigational New Drug application.
[Calidi Biotherapeutics, Inc.]
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February 19 – 22, 2023
New Orleans, Louisiana, United States
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Rutgers Biomedical and Health Sciences – Newark, New Jersey, United States
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Westlake University – Hangzhou, China
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Flanders Institute for Biotechnology – Leuven, Belgium
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University of California Irvine – Irvine, California, United States
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Novartis – Boston, Massachusetts, United States
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Cancer Stem Cell News
Cell Therapy News
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