 | | Vol. 12.01 – 11 January, 2023 |
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| Using lineage tracing, limiting dilution assays, and in vivo live imaging approaches, scientists identified a rare inhibitory receptor programmed cell death 1 (PD-1)-expressing cells that resided at the apex of leukemia hierarchy for initiation and relapse in T cell acute lymphoblastic laukemia.
[Nature Cell Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| METTL16 was aberrantly overexpressed in human acute myeloid leukemia cells, especially in leukemia stem cells and leukemia-initiating cells.
[Cell Stem Cell] |
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| To investigate the CSC properties of pancreatic cancer cells, the authors used a pancreatic CSC model, degron (++) cells, which have low proteasome activity. Degron (++) cells displayed radioresistance in comparison with control cells.
[Molecular Therapy] |
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| Results using hepatocellular carcinoma patient samples showed a positive correlation between indoleamine 2,3-dioxygenase-1, a kynurenine producing enzyme with effects on tumor immune escape, and Lin28B.
[Molecular Therapy] |
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| Scientists demonstrated that RAC1B, the only known alternatively spliced variant of the small GTPase RAC1, was expressed in a subset of breast CSCs (BCSCs) in vivo and its function was required for the maintenance of BCSCs and their chemoresistance to doxorubicin.
[Oncogene] |
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| Researchers explored the relationship between mesenchymal circulating tumor cells and Ki67 in hepatocellular carcinoma and their ability to predict prognosis.
[BMC Cancer] |
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| High expression of ATP Binding Cassette subfamily C member 3 (ABCC3) was restricted to glioblastoma, with negligible levels in healthy brain tissue, and further correlated with tumor grade and stemness markers.
[Scientific Reports] |
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| Investigators developed procedures to efficiently activate T cells with tumor-associated antigens to glioblastoma stem cells.
[Scientific Reports] |
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| The degree of stromal tumor-infiltrating lymphocytes was evaluated using hematoxylin and eosin-stained slides. Immunohistochemical analysis of B7-H4, CSC-related biomarkers, and epithelial-mesenchymal-transition-related biomarkers was performed using tissue microarray.
[Journal Of Ovarian Research] |
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| CSCs have obvious radio-resistance compared with non-CSCs, and charged particle irradiation or in combination with drugs could overcome this resistance, specifically manifested in inhibiting CSCs’ proliferation, invasion, migration, and causing more DNA double-stranded breaks (DSB) of CSCs.
[Journal Of Cancer Research And Clinical Oncology] |
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| The initial Phase I clinical trial will assess safety and therapeutic benefit from the administration of Phio’s PH-762 treated “double positive” CD8 tumor infiltrating lymphocyte in patients with melanoma and other advanced solid tumors.
[Phio Pharmaceuticals Corp.] |
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| Zai Lab Limited and Novocure announced the LUNAR study met its primary endpoint, demonstrating a statistically significant and clinically meaningful improvement in overall survival over standard therapies alone.
[Zai Lab Limited] |
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| March 26 – 31, 2023
Ventura, California, United States |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Stanford Medicine – Stanford, California, United States |
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| | Rutgers Biomedical and Health Sciences – Newark, New Jersey, United States |
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| | Westlake University – Hangzhou, China |
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