Cancer Stem Cell News Volume 12.01 | Jan 11 2022

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    2023-01-11 | CSCN 12.01


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.01 – 11 January, 2023
    TOP STORY

    PD-1 Signaling Defines and Protects Leukemic Stem Cells from T Cell Receptor-Induced Cell Death in T Cell Acute Lymphoblastic Leukemia

    Using lineage tracing, limiting dilution assays, and in vivo live imaging approaches, scientists identified a rare inhibitory receptor programmed cell death 1 (PD-1)-expressing cells that resided at the apex of leukemia hierarchy for initiation and relapse in T cell acute lymphoblastic laukemia.
    [Nature Cell Biology]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    METTL16 Drives Leukemogenesis and Leukemia Stem Cell Self-Renewal by Reprogramming BCAA Metabolism

    METTL16 was aberrantly overexpressed in human acute myeloid leukemia cells, especially in leukemia stem cells and leukemia-initiating cells.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    KRT13 Is Upregulated in Pancreatic Cancer Stem-Like Cells and Associated with Radioresistance

    To investigate the CSC properties of pancreatic cancer cells, the authors used a pancreatic CSC model, degron (++) cells, which have low proteasome activity. Degron (++) cells displayed radioresistance in comparison with control cells.
    [Molecular Therapy]

    Abstract

    Targeting Lin28 Axis Enhances Glypican-3-CAR T Cell Efficacy Against Hepatic Tumor Initiating Cell Population

    Results using hepatocellular carcinoma patient samples showed a positive correlation between indoleamine 2,3-dioxygenase-1, a kynurenine producing enzyme with effects on tumor immune escape, and Lin28B.
    [Molecular Therapy]

    AbstractGraphical Abstract

    RAC1B Function Is Essential for Breast Cancer Stem Cell Maintenance and Chemoresistance of Breast Tumor Cells

    Scientists demonstrated that RAC1B, the only known alternatively spliced variant of the small GTPase RAC1, was expressed in a subset of breast CSCs (BCSCs) in vivo and its function was required for the maintenance of BCSCs and their chemoresistance to doxorubicin.
    [Oncogene]

    Abstract

    Mesenchymal Circulating Tumor Cells and Ki67: Their Mutual Correlation and Prognostic Implications in Hepatocellular Carcinoma

    Researchers explored the relationship between mesenchymal circulating tumor cells and Ki67 in hepatocellular carcinoma and their ability to predict prognosis.
    [BMC Cancer]

    Full Article

    Nanobodies Targeting ABCC3 for Immunotargeted Applications in Glioblastoma

    High expression of ATP Binding Cassette subfamily C member 3 (ABCC3) was restricted to glioblastoma, with negligible levels in healthy brain tissue, and further correlated with tumor grade and stemness markers.
    [Scientific Reports]

    Full Article

    Activated T Cell Therapy Targeting Glioblastoma Cancer Stem Cells

    Investigators developed procedures to efficiently activate T cells with tumor-associated antigens to glioblastoma stem cells.
    [Scientific Reports]

    Full Article

    The Stromal Tumor-Infiltrating Lymphocytes, Cancer Stemness, Epithelial-Mesenchymal Transition, and B7-H4 Expression in Ovarian Serous Carcinoma

    The degree of stromal tumor-infiltrating lymphocytes was evaluated using hematoxylin and eosin-stained slides. Immunohistochemical analysis of B7-H4, CSC-related biomarkers, and epithelial-mesenchymal-transition-related biomarkers was performed using tissue microarray.
    [Journal Of Ovarian Research]

    Full Article
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    REVIEWS

    Biological Effects of Cancer Stem Cells Irradiated by Charged Particle: A Systematic Review of In Vitro Studies

    CSCs have obvious radio-resistance compared with non-CSCs, and charged particle irradiation or in combination with drugs could overcome this resistance, specifically manifested in inhibiting CSCs’ proliferation, invasion, migration, and causing more DNA double-stranded breaks (DSB) of CSCs.
    [Journal Of Cancer Research And Clinical Oncology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Phio Pharmaceuticals Announces Regulatory Clearance of Clinical Trial with PH-762 and AgonOx’s Tumor Infiltrating Lymphocytes to Treat Solid Tumors

    The initial Phase I clinical trial will assess safety and therapeutic benefit from the administration of Phio’s PH-762 treated “double positive” CD8 tumor infiltrating lymphocyte in patients with melanoma and other advanced solid tumors.
    [Phio Pharmaceuticals Corp.]

    Press Release

    Zai Lab and Novocure Announce Pivotal LUNAR Study in Non-Small Cell Lung Cancer Met Primary Overall Survival Endpoint

    Zai Lab Limited and Novocure announced the LUNAR study met its primary endpoint, demonstrating a statistically significant and clinically meaningful improvement in overall survival over standard therapies alone.
    [Zai Lab Limited]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Systems Biology

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

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    Albert Einstein College of Medicine – Bronx, New York, United States

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    Stanford Medicine – Stanford, California, United States

    Faculty Positions – Translational Biomedical Research

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