Cancer Stem Cell News Volume 12.02 | Jan 17 2023

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    2023-01-17 | CSCN 12.02


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.02 – 17 January, 2023
    TOP STORY

    Pancreatic Cancer Cells Upregulate LPAR4 in Response to Isolation Stress To Promote an ECM-Enriched Niche and Support Tumour Initiation

    Scientists reported that lysophosphatidic acid receptor 4 (LPAR4) became transiently upregulated on pancreatic cancer cells exposed to environmental stress or chemotherapy, promoting stress tolerance, drug resistance, self-renewal, and tumor initiation.
    [Nature Cell Biology]

    Full ArticlePress Release
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    Niche Stiffness Sustains Cancer Stemness via TAZ and NANOG Phase Separation

    Investigators revealed that increased matrix stiffness was associated with poor responses to neoadjuvant chemotherapy, worse prognosis, and CSC enrichment in patients with breast cancer.
    [Nature Communications]

    Full Article

    ASPM Activates Hedgehog and Wnt Signaling To Promote Small Cell Lung Cancer Stemness and Progression

    Researchers identified isoform 1 of the neurogenesis-associated protein ASPM as a prominently upregulated stemness-associated gene during the self-renewal of small cell lung cancer cells.
    [Cancer Research]

    Abstract

    The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression

    The authors reported the overexpression of YTHDF1, an m6A reader protein, in human acute myeloid leukemia samples at the protein level with enrichment in leukemia stem cells.
    [Cancer Research]

    Abstract

    The U2AF65/circNCAPG/RREB1 Feedback Loop Promotes Malignant Phenotypes of Glioma Stem Cells through Activating the TGF-β Pathway

    Researchers identified a novel circRNA named circNCAPG that was overexpressed and indicated poor prognosis in glioma patients. Upregulating circNCAPG promoted the malignant progression of glioma stem cells.
    [Cell Death & Disease]

    Full Article

    Tyrosine Kinase SRC-Induced YAP1-KLF5 Module Regulates Cancer Stemness and Metastasis in Triple-Negative Breast Cancer

    Scientists identified a YAP1 tyrosine phosphorylation-dependent YAP1-Kruppel-like factor 5 (KLF5) oncogenic module, as the key downstream mediator of SRC kinase regulating cancer stemness and metastasis in triple-negative breast cancer.
    [Cellular And Molecular Life Sciences]

    Full Article

    PTBP1 Drives C-Myc-Dependent Gastric Cancer Progression and Stemness

    Polypyrimidine tract binding protein 1 (PTBP1) maintained the tumorigenic activity and stem-cell characteristics of gastric cancer in vitro and in vivo.
    [British Journal Of Cancer]

    Full Article

    Short Peptide Domains of the Wnt Inhibitor sFRP4 Target Ovarian Cancer Stem Cells by Neutralizing the Wnt β-Catenin Pathway, Disrupting the Interaction Between β-Catenin and CD24 and Suppressing Autophagy

    The authors explored the effectiveness of short micropeptides SC-301 and SC-401 on CSC properties, epithelial-mesenchymal transition, apoptosis, and autophagy in ovarian CSCs enriched from PA-1 and SKOV-3 cell lines.
    [Life Sciences]

    Abstract

    SERPINA12 Promotes the Tumorigenic Capacity of Hepatocellular Carcinoma Stem Cells through Hyperactivation of AKT/ β-Catenin Signaling

    Transcriptome profiling of epithelial-specific ‘normal’ CD133+ cells isolated from fetal and regenerating liver against ‘HCC’ CD133+ cells isolated from proto-oncogene driven and inflammation-associated HCC revealed preferential overexpression of SERPINA12 in HCC but not fetal and regenerating liver CD133+ cells.
    [Hepatology]

    Abstract
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    REVIEWS

    Metabolism in Stem Cell Driven Leukemia: Parallels Between Hematopoiesis and Immunity

    Scientists review how leukemia remodels the niche and rewires its metabolism with particular attention paid to therapy-resistant stem cells.
    [Blood]

    Abstract

    Targeting the Epigenome of Cancer Stem Cells in Pediatric Nervous System Tumors

    Investigators review the contribution of different epigenetic regulatory mechanisms and some of the main effects of epigenetic-modulating agents in pediatric nervous system tumor CSCs.
    [Molecular and Cellular Biochemistry]

    Abstract
    INDUSTRY AND POLICY NEWS

    FDA No Longer Needs to Require Animal Tests before Human Drug Trials

    New medicines need not be tested in animals to receive FDA approval, according to legislation signed by President Joe Biden in late December 2022.
    [ScienceInsider]

    Press Release
    FEATURED EVENT

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    April 14 – 19, 2023
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    JOB OPPORTUNITIES

    Postdoctoral Scientist – Cellular Senescence, Cancer, and Aging

    Cancer Research Center of Lyon – Lyon, France

    Postdoctoral Training Fellow – Telomere Biology Team

    Institute of Cancer Research – London, England, United Kingdom

    Postdoctoral Fellowship – Systems Biology

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Researcher – Cellular Motility, Migration, and Signaling Pathways

    Albert Einstein College of Medicine – Bronx, New York, United States

    Research Scientist – Cancer Molecular Imaging

    Stanford Medicine – Stanford, California, United States

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