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Vol. 12.02 – 17 January, 2023
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Scientists reported that lysophosphatidic acid receptor 4 (LPAR4) became transiently upregulated on pancreatic cancer cells exposed to environmental stress or chemotherapy, promoting stress tolerance, drug resistance, self-renewal, and tumor initiation. [Nature Cell Biology]
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PUBLICATIONSRanked by the impact factor of the journal
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Investigators revealed that increased matrix stiffness was associated with poor responses to neoadjuvant chemotherapy, worse prognosis, and CSC enrichment in patients with breast cancer.
[Nature Communications]
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Researchers identified isoform 1 of the neurogenesis-associated protein ASPM as a prominently upregulated stemness-associated gene during the self-renewal of small cell lung cancer cells. [Cancer Research]
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The authors reported the overexpression of YTHDF1, an m6A reader protein, in human acute myeloid leukemia samples at the protein level with enrichment in leukemia stem cells.
[Cancer Research]
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Researchers identified a novel circRNA named circNCAPG that was overexpressed and indicated poor prognosis in glioma patients. Upregulating circNCAPG promoted the malignant progression of glioma stem cells.
[Cell Death & Disease]
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Scientists identified a YAP1 tyrosine phosphorylation-dependent YAP1-Kruppel-like factor 5 (KLF5) oncogenic module, as the key downstream mediator of SRC kinase regulating cancer stemness and metastasis in triple-negative breast cancer. [Cellular And Molecular Life Sciences]
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Polypyrimidine tract binding protein 1 (PTBP1) maintained the tumorigenic activity and stem-cell characteristics of gastric cancer in vitro and in vivo.
[British Journal Of Cancer]
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The authors explored the effectiveness of short micropeptides SC-301 and SC-401 on CSC properties, epithelial-mesenchymal transition, apoptosis, and autophagy in ovarian CSCs enriched from PA-1 and SKOV-3 cell lines.
[Life Sciences]
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Transcriptome profiling of epithelial-specific ‘normal’ CD133+ cells isolated from fetal and regenerating liver against ‘HCC’ CD133+ cells isolated from proto-oncogene driven and inflammation-associated HCC revealed preferential overexpression of SERPINA12 in HCC but not fetal and regenerating liver CD133+ cells. [Hepatology]
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Scientists review how leukemia remodels the niche and rewires its metabolism with particular attention paid to therapy-resistant stem cells.
[Blood]
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Investigators review the contribution of different epigenetic regulatory mechanisms and some of the main effects of epigenetic-modulating agents in pediatric nervous system tumor CSCs. [Molecular and Cellular Biochemistry]
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New medicines need not be tested in animals to receive FDA approval, according to legislation signed by President Joe Biden in late December 2022. [ScienceInsider]
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April 14 – 19, 2023 Orlando, Florida, United States
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Cancer Research Center of Lyon – Lyon, France
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Institute of Cancer Research – London, England, United Kingdom
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The University of Texas MD Anderson Cancer Center – Houston, Texas, United States
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Albert Einstein College of Medicine – Bronx, New York, United States
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Stanford Medicine – Stanford, California, United States
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