Cancer Stem Cell News Volume 12.03 | Jan 25 2023

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    2023-01-25 | CSCN 12.03


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.03 – 25 January, 2023
    TOP STORY

    Targeting De Novo Lipid Synthesis Induces Lipotoxicity and Impairs DNA Damage Repair in Glioblastoma Mouse Models

    Investigators reported that YTX-7739 triggered lipotoxicity in patient-derived glioblastoma stem-like cells (GSCs) and inhibited fatty acid desaturation in GSCs orthotopically implanted in mice.
    [Science Translational Medicine]

    AbstractPress Release
    Use STEMvision™ for Automated Hematopoietic CFU Assay Imaging & Analysis.
    PUBLICATIONSRanked by the impact factor of the journal

    A Bio-Orthogonal Linear Ubiquitin Probe Identifies STAT3 as a Direct Substrate of OTULIN in Glioblastoma

    Researchers demonstrated the feasibility of the norbornene amino acid on ubiquitin strategy by identifying and validating substrates of linear ubiquitination in patient-derived glioblastoma stem-like cells.
    [Nucleic Acids Research]

    Full Article
    Graphical
    Abstract

    Loss of RanGAP1 Drives Chromosome Instability and Rapid Tumorigenesis of Osteosarcoma

    Scientists showed that reduction and inactivation of Ran GTPase-activating protein 1 (RanGAP1) commonly occured in human osteosarcoma, which was associated with a high rate of chromothripsis.
    [Developmental Cell]

    AbstractGraphical Abstract

    Basal-Like Mammary Carcinomas Stimulate Cancer Stem Cell Properties through AXL-Signaling to Induce Chemotherapy Resistance

    The authors leveraged the WAP-T syngeneic mammary carcinoma mouse model and developed a strategy combining magnetic-activated cell sorting-based tumor cell enrichment with high-throughput transcriptome analyses.
    [International Journal of Cancer]

    Abstract

    METTL3 Knockdown Promotes Temozolomide Sensitivity of Glioma Stem Cells via Decreasing MGMT and APNG mRNA Stability

    Scientists found that the cell viability and half-maximal inhibitory concentration of glioma stem cells (GSCs) against temozolomide significantly decreased after GSCs underwent serum-induced differentiation to adherent growth of tumor cells.
    [Cell Death Discovery]

    Full Article

    Tetrandrine Inhibits Cancer Stem Cell Characteristics and Epithelial to Mesenchymal Transition in Triple-Negative Breast Cancer via SOD1/ROS Signaling Pathway

    The effects of tetrandrine on cell growth, cell viability, cell stemness capacity, cell migration, and cell invasion, as well as the molecules involved in these processes, were investigated in a cell culture system.
    [American Journal Of Chinese Medicine]

    Abstract

    A Curcumin Analogue GO-Y030 Depletes Cancer Stem Cells by Inhibiting the Interaction between the HSP70/HSP40 Complex and Its Substrates

    Researchers verified the potency of GO-Y030 against a CSC population and observed that GO-Y030 suppressed CSC sphere-forming ability in several cancer cell lines.
    [FEBS Open Bio]

    Full Article

    MUC1 Promotes Cancer Stemness and Predicts Poor Prognosis in Osteosarcoma

    Scientists observed elevated myxoprotein 1 (MUC1) in osteosarcoma and a depressed prognosis in patients with high MUC1 expression profiles.
    [Pathology Research And Practice]

    Abstract

    A Simple and Sensitive Electrochemical Biosensor for Circulating Tumor Cell Determination Based on Dual-Toehold Accelerated Catalytic Hairpin Assembly

    Investigators have established an enzyme-free, easy-to-operate, and non-disruptive method for detecting circulating tumor cells in blood circulation based on the dual-toehold accelerated catalytic hairpin assembly strategy.
    [Microchimica Acta]

    AbstractGraphical Abstract
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    REVIEWS

    Chromatin and Noncoding RNA-Mediated Mechanisms of Gastric Tumorigenesis

    The authors focus on discussing recent discoveries addressing the roles of histone modifiers and noncoding RNAs and the mechanisms of their interactions in gastric tumorigenesis.
    [Experimental & Molecular Medicine]

    Full Article

    Cancer Stem Cells Are Actually Stem Cells With Disordered Differentiation: The Monophyletic Origin of Cancer

    Scientists propose a monophyletic origin of cancer model which suggests that CSCs are stem cells that lose control of differentiation.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Damon Runyon Awards $3.2M to Innovative Early-Career Scientists

    The Damon Runyon Cancer Research Foundation has announced eight recipients of the 2023 Damon Runyon-Rachleff Innovation Award, established to support “high-risk, high-reward” ideas with the potential to significantly impact the prevention, diagnosis, or treatment of cancer.
    [Damon Runyon Cancer Research Foundation]

    Press Release

    Gabor Tigyi Receives Prestigious International Award for Research

    Dr. Gabor Tigyi of the University of Tennessee Health Science Center was announced as the recipient of the 2022 Dénes Gábor Prize for scientific innovation.
    [The University of Tennessee Health Science Center]

    Press Release
    FEATURED EVENT

    3D Cell Culture 2023: Models, Applications & Translation

    April 17 – 19, 2023
    Freiburg im Breisgau, Germany

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancer Biology

    University of Bergen – Bergen, Norway

    Faculty Position – Cancer Stem Cell Biology

    Michigan State University – East Lansing, Michigan, United States

    Research Associate – CAR T Immunotherapy

    Imperial College London – London, United Kingdom

    Directors of Clinical Research Programs – Cancer Biology

    IRCCS Candiolo Cancer Institute – Turin, Italy

    Postdoctoral Scientist – Cellular Senescence, Cancer, and Aging

    Cancer Research Center of Lyon – Lyon, France

    > See All Jobs

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