| Vol. 12.03 – 25 January, 2023 |
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| Investigators reported that YTX-7739 triggered lipotoxicity in patient-derived glioblastoma stem-like cells (GSCs) and inhibited fatty acid desaturation in GSCs orthotopically implanted in mice. [Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated the feasibility of the norbornene amino acid on ubiquitin strategy by identifying and validating substrates of linear ubiquitination in patient-derived glioblastoma stem-like cells. [Nucleic Acids Research] |
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| Scientists showed that reduction and inactivation of Ran GTPase-activating protein 1 (RanGAP1) commonly occured in human osteosarcoma, which was associated with a high rate of chromothripsis. [Developmental Cell] |
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| The authors leveraged the WAP-T syngeneic mammary carcinoma mouse model and developed a strategy combining magnetic-activated cell sorting-based tumor cell enrichment with high-throughput transcriptome analyses. [International Journal of Cancer] |
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| Scientists found that the cell viability and half-maximal inhibitory concentration of glioma stem cells (GSCs) against temozolomide significantly decreased after GSCs underwent serum-induced differentiation to adherent growth of tumor cells. [Cell Death Discovery] |
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| The effects of tetrandrine on cell growth, cell viability, cell stemness capacity, cell migration, and cell invasion, as well as the molecules involved in these processes, were investigated in a cell culture system. [American Journal Of Chinese Medicine] |
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| Researchers verified the potency of GO-Y030 against a CSC population and observed that GO-Y030 suppressed CSC sphere-forming ability in several cancer cell lines. [FEBS Open Bio] |
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| Scientists observed elevated myxoprotein 1 (MUC1) in osteosarcoma and a depressed prognosis in patients with high MUC1 expression profiles. [Pathology Research And Practice] |
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| Investigators have established an enzyme-free, easy-to-operate, and non-disruptive method for detecting circulating tumor cells in blood circulation based on the dual-toehold accelerated catalytic hairpin assembly strategy. [Microchimica Acta] |
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| The authors focus on discussing recent discoveries addressing the roles of histone modifiers and noncoding RNAs and the mechanisms of their interactions in gastric tumorigenesis. [Experimental & Molecular Medicine] |
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| Scientists propose a monophyletic origin of cancer model which suggests that CSCs are stem cells that lose control of differentiation. [Stem Cell Reviews and Reports] |
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| The Damon Runyon Cancer Research Foundation has announced eight recipients of the 2023 Damon Runyon-Rachleff Innovation Award, established to support “high-risk, high-reward” ideas with the potential to significantly impact the prevention, diagnosis, or treatment of cancer. [Damon Runyon Cancer Research Foundation] |
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| Dr. Gabor Tigyi of the University of Tennessee Health Science Center was announced as the recipient of the 2022 Dénes Gábor Prize for scientific innovation. [The University of Tennessee Health Science Center] |
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| April 17 – 19, 2023 Freiburg im Breisgau, Germany |
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| University of Bergen – Bergen, Norway |
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| Michigan State University – East Lansing, Michigan, United States |
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| Imperial College London – London, United Kingdom |
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| IRCCS Candiolo Cancer Institute – Turin, Italy |
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| Cancer Research Center of Lyon – Lyon, France |
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