Cancer Stem Cell News Volume 12.07 | Feb 22 2023


    2023-02-22 | CSCN 12.07

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.07 – 22 February, 2023

    Sorting-Nexin-10 Sustains Platelet-Derived Growth Factor Receptor Signaling in Glioblastoma Stem Cells via Endosomal Protein Sorting

    To understand the molecular processes essential for maintaining glioblastoma stem cells (GSCs), researchers performed an integrative analysis comparing active enhancer landscapes, transcriptional profiles, and functional genomics profiles of GSCs and non-neoplastic neural stem cells.
    [Journal of Clinical Insight]

    AbstractGraphical Abstract
    PUBLICATIONSRanked by the impact factor of the journal

    Dipeptidylpeptidase 4 Promotes Survival and Stemness of Acute Myeloid Leukemia Stem Cells

    Investigators performed an unbiased screening of compounds targeting cell surface proteins and identify clinically used DPP4 inhibitors as strong suppressors of acute myeloid leukemia (AML) development in both murine AML models and primary human AML cells xenograft model.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Selective and Brain-Penetrant Lanosterol Synthase Inhibitors Target Glioma Stem-Like Cells by Inducing 24(S), 25-Epoxycholesterol Production

    The authors investigated the mechanism of MM0299, a tetracyclic dicarboximide with anti-glioblastoma activity. MM0299 inhibited lanosterol synthase and diverted sterol flux away from cholesterol into a “shunt” pathway that culminated in 24(S),25-epoxycholesterol.
    [Cell Chemical Biology]

    Full ArticleGraphical Abstract

    Manipulation and Elimination of Circulating Tumor Cells Using Multi-Responsive Nanosheet for Malignant Tumor Therapy

    A magnet-NIR-pH multi-responsive nanosheet was fabricated to capture ciculating tumor cells (CTCs) in circulation, then magnetically transport them to the primary tumor, and finally perform NIR-dependent photothermal therapy to destroy both the CTCs and the primary tumor.
    [Biomaterials Science]

    AbstractGraphical Abstract

    Luteolin Directly Binds to KDM4C and Attenuates Ovarian Cancer Stemness via Epigenetic Suppression of PPP2CA/YAP Axis

    Scientists reported that luteolin, a natural flavonoid, attenuated the stemness of ovarian CSCs by directly binding to KDM4C and epigenetic suppression of PPP2CA/YAP axis.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    PLK1 Inhibition Promotes Apoptosis and DNA Damage in Glioma Stem Cells by Regulating the Nuclear Translocation of YBX1

    Researchers identified that polo-like kinase 1 (PLK1) inhibition induced apoptosis and DNA damage of glioma stem cells. They also delineated the possible underlying molecular mechanisms: PLK1 interacted with YBX1 and directly phosphorylated serine 174 and serine 176 of YBX1.
    [Cell Death Discovery]

    Full ArticleGraphical Abstract

    LIN28 and Histone H3K4 Methylase Induce TLR4 to Generate Tumor-Initiating Stem-Like Cells

    The authors investigated mechanisms as to how tumor-initiating stem-like cells arise through transcriptional, epigenetic, and post-transcriptional activation of oncogenic TLR4 pathways.

    Full ArticleGraphical Abstract

    1′-O-Methyl-Averantin Isolated from the Endolichenic Fungus Jackrogersella sp. EL001672 Suppresses Colorectal Cancer Stemness via Sonic Hedgehog and Notch Signaling

    Scientists examined the ability of an extract of Jackrogersella sp. EL001672 and the isolated compound 1′-O-methyl-averantin to inhibit development of cancer stemness.
    [Scientific Reports]

    Full Article

    Breast Cancer Stem Cell-Derived Extracellular Vesicles Transfer ARRDC1-AS1 to Promote Breast Carcinogenesis via a miR-4731-5p/AKT1 Axis-Dependent Mechanism

    Investigators clarified a carcinogenic mechanism based on the ARRDC1-AS1 delivered by breast cancer stem cells-derived extracellular vesicles in breast cancer.
    [Translational Oncology]

    Full Article
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    Preclinical Models to Study Patient-Derived Circulating Tumor Cells and Metastasis

    Scientists summarize the successes, challenges, and limitations that collectively contribute to a better understanding of metastasis using patient-derived circulating tumor cells as blood-borne seeds of metastasis.
    [Trends in Cancer]


    FDA to Require Diversity Plan for Clinical Trials

    The FDA will soon require researchers and companies seeking approval for late-stage clinical trials to submit a plan for ensuring diversity among trial participants.
    [Nature News]

    Full Article

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    Postdoctoral Researcher – Type III Collagen

    Penn Medicine – Philadelphia, Pennsylvania, United States

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    The Henry Ford Health System – Detroit, Michigan, United States

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    The University of Melbourne – Melbourne, Australia

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    Howard Hughes Medical Institute – Dallas, Texas, United States

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    The University of Melbourne – Melbourne, Australia

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