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Vol. 12.07 – 22 February, 2023
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To understand the molecular processes essential for maintaining glioblastoma stem cells (GSCs), researchers performed an integrative analysis comparing active enhancer landscapes, transcriptional profiles, and functional genomics profiles of GSCs and non-neoplastic neural stem cells. [Journal of Clinical Insight]
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PUBLICATIONSRanked by the impact factor of the journal
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Investigators performed an unbiased screening of compounds targeting cell surface proteins and identify clinically used DPP4 inhibitors as strong suppressors of acute myeloid leukemia (AML) development in both murine AML models and primary human AML cells xenograft model.
[Cell Reports]
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The authors investigated the mechanism of MM0299, a tetracyclic dicarboximide with anti-glioblastoma activity. MM0299 inhibited lanosterol synthase and diverted sterol flux away from cholesterol into a “shunt” pathway that culminated in 24(S),25-epoxycholesterol.
[Cell Chemical Biology]
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A magnet-NIR-pH multi-responsive nanosheet was fabricated to capture ciculating tumor cells (CTCs) in circulation, then magnetically transport them to the primary tumor, and finally perform NIR-dependent photothermal therapy to destroy both the CTCs and the primary tumor.
[Biomaterials Science]
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Scientists reported that luteolin, a natural flavonoid, attenuated the stemness of ovarian CSCs by directly binding to KDM4C and epigenetic suppression of PPP2CA/YAP axis.
[Biomedicine & Pharmacotherapy]
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Researchers identified that polo-like kinase 1 (PLK1) inhibition induced apoptosis and DNA damage of glioma stem cells. They also delineated the possible underlying molecular mechanisms: PLK1 interacted with YBX1 and directly phosphorylated serine 174 and serine 176 of YBX1.
[Cell Death Discovery]
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The authors investigated mechanisms as to how tumor-initiating stem-like cells arise through transcriptional, epigenetic, and post-transcriptional activation of oncogenic TLR4 pathways.
[iScience]
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Scientists examined the ability of an extract of Jackrogersella sp. EL001672 and the isolated compound 1′-O-methyl-averantin to inhibit development of cancer stemness.
[Scientific Reports]
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Investigators clarified a carcinogenic mechanism based on the ARRDC1-AS1 delivered by breast cancer stem cells-derived extracellular vesicles in breast cancer. [Translational Oncology]
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Scientists summarize the successes, challenges, and limitations that collectively contribute to a better understanding of metastasis using patient-derived circulating tumor cells as blood-borne seeds of metastasis. [Trends in Cancer]
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The FDA will soon require researchers and companies seeking approval for late-stage clinical trials to submit a plan for ensuring diversity among trial participants. [Nature News]
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March 31, 2023 Amsterdam, The Netherlands
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Penn Medicine – Philadelphia, Pennsylvania, United States
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The Henry Ford Health System – Detroit, Michigan, United States
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The University of Melbourne – Melbourne, Australia
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Howard Hughes Medical Institute – Dallas, Texas, United States
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The University of Melbourne – Melbourne, Australia
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