Cancer Stem Cell News Volume 12.09 | Mar 8 2023


    2023-03-08 | CSCN 12.09

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.09 – 8 March, 2023

    Detection and Targeting of Splicing Deregulation in Pediatric Acute Myeloid Leukemia Stem Cells

    Researchers described single-cell proteogenomics analyses, transcriptome-wide analyses of FACS-purified hematopoietic stem and progenitor cells followed by differential splicing analyses, dual-fluorescence lentiviral splicing reporter assays, and Rebecsinib in pediatric acute myeloid leukemia.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract
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    Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence after Chemotherapy of Intestinal Tumors

    Scientists established a syngeneic orthotopic transplantation model in mice based on intestinal cancer organoids to profile quiescent CSCs.
    [Cancer Research]


    NAD Pool as an Antitumor Target against Cancer Stem Cells in Head and Neck Cancer

    Researchers observed that nicotinamide phosphoribosyltransferase reduction caused a decrease in tumorigenic and stemness properties, migration capacity, and CSC phenotype through nicotinamide adenine dinucleotide (NAD) pool depletion.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    PVT1/miR-136/Sox2/UPF1 Axis Regulates the Malignant Phenotypes of Endometrial Cancer Stem Cells

    Investigators found that plasmacytoma variant translocation 1 (PVT1) was highly expressed in endometrial cancers and endometrial CSCs (ECSCs), correlated with poor patient prognosis, promoted the malignant behavior and the stemness of endometrial cancer cells and ECSCs.
    [Cell Death & Disease]

    Full Article

    Very Small Embryonic-Like Stem Cells Transform into Cancer Stem Cells and Are Novel Candidates for Detecting/Monitoring Cancer by a Simple Blood Test

    Researchers posited that pluripotent, endogenous, tissue-resident, very small embryonic-like stem cells that exist in small numbers in all adult tissues, exit from their quiescent state due to epigenetic changes in response to various insults and transform into CSCs to initiate cancer.
    [Stem Cells]

    AbstractGraphical Abstract

    Cuproptosis-Related Gene PDHX and Heat Stress-Related HSPD1 as Potential Key Drivers Associated with Cell Stemness, Aberrant Metabolism and Immunosuppression in Esophageal Carcinoma

    The authors analyzed the key regulatory cell death genes involved in heat stress and esophageal carcinoma (ESCA) progression by using The Cancer Genome Atlas-ESCA database.
    [International Immunopharmacology]

    Full Article

    A Platinum(II) Complex HY1-Pt Overcomes Cisplatin-Induced Resistance and Attenuates Metastasis of Epithelial Ovarian Cancer by Cancer Cell Stemness Inhibition

    HY1-Pt showed highly efficient anti-tumor effect with low toxicity for either cisplatin-sensitive or cisplatin-resistant epithelial ovarian cancer both in vitro and in vivo.
    [The International Journal of Biochemistry & Cell Biology]

    AbstractGraphical Abstract

    Ex Vivo Expansion of Circulating Tumor Cells (CTCs)

    Scientists reported a new methodology, which optimized the culture conditions for CTCs using primary cancer cells as a model system.
    [Scientific Reports]

    Full Article

    Genomic Characteristics and Clinical Significance of CD56+ Circulating Tumor Cells in Small Cell Lung Cancer

    The authors developed an EpCAM-independent circulating tumor cells (CTC) isolation method that isolated a broader range of living CTC from small-cell lung cancer and deciphered their genomic and biological characteristics.
    [Scientific Reports]

    Full Article
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.

    Relevance of Glyco-Biomakers and Glycan Profiles in Cancer Stem Cells

    Investigators discuss the function of carbohydrates as prospective serum biomarkers, some clinically authorized biomarkers, and potential novel biomarkers relating to cancer disease diagnosis and prognosis.


    Advances in Understanding the Role and Mechanisms of Tumor Stem Cells in HER2-Positive Breast Cancer Treatment Resistance

    The authors review the roles of breast CSCs in the occurrence, development, and management of breast cancer treatment resistance.
    [International Journal of Oncology]


    Cancer Will Cost the World $25 Trillion over Next 30 Years

    The total cost of cancer to the global economy will reach 25.2 trillion international dollars between 2020 and 2050, according to an analysis of 29 cancers across 204 countries.

    Press Release

    Genomics of Rare Disease

    April 24 – 26, 2023
    Hinxton, England, United Kingdom

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    Research Technician – RNA Vaccines and Therapies

    University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral, Student, and Technician Positions – Stem-Immunology

    Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States

    Managing Director – Organoid Development Core Facility

    Rutgers Biomedical and Health Sciences – New Brunswick, New Jersey, United States

    Computational Biologist – Cancer and Glioma Stem Cell Biology

    Weill Cornell College of Medicine – New York, New York, United States

    Postdoctoral Fellow – Cancer Stem Cells in Metastasis

    Albert Einstein College of Medicine – New York, New York, United States

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