 | | Vol. 12.11 – 22 March, 2023 |
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| Researchers reported Insulin-like Growth Factor-Binding Protein 5 (IGFBP5), a ligand for Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1), as a promising target for glioblastoma stem-like cell invasion.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To better understand the mechanisms involved in tumor microenvironment-mediated generation and support of urothelial bladder cancer CSCs, scientists focused on the role of cancer-associated fibroblasts.
[Cancer Research] |
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| In vitro and in vivo loss-of-function genetic and pharmacologic assays were conducted to evaluate the effect of Sterol Regulatory Element-Binding Protein 2 (SREBP2) on glioblastoma cholesterol biosynthesis, proliferation, and self-renewal.
[Neuro-Oncology] |
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| Scientists evaluated the immune effects of CSCs vaccines on ovarian cancer (OC). The CD44+CD117+CSCs were isolated from human OC HO8910 and SKOV3 cells using the magnetic cell sorting system.
[Biomedicine & Pharmacotherapy] |
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| The authors found that depleting DEAD-box helicase 1 (DDX1) increased the sensitivity of non-small cell lung cancer cells to the chemotherapy drug cisplatin, increased cell apoptosis, and inhibited cell migration and invasion.
[Life Sciences] |
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| Scientists investigated organoids, miniature forms of tumor tissues with reconstructing cellular diversity, to identify specific marker to characterize CSCs in heterogeneous tumors.
[Cancer Science] |
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| Researchers demonstrated that 3T3-L1 adipocyte conditioned media could endow PC3 and DU145 prostate cancer cells with stemness properties, by stimulating their sphere formation ability and promoting CD133 and CD44 expression.
[Journal of Cell Communication and Signaling] |
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| To investigate the relevant molecular mechanism and signal pathway of glioma stem cell behavior mediated by thrombospondin 1 (THBS1), U251 astroglioma cells and glioma stem cells were taken as model cells for in vitro experiments.
[Cellular Signalling] |
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| The authors showed that long non-coding RNA WT1 antisense RNA (WT1-AS) negatively regulated Wilms’ tumor 1 (WT1) expression in gastric CSCs.
[Heliyon] |
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| Investigators reported the silicon nanowire array differentiated MCF-7-derived breast CSCs into non-CSCs by modulating the morphology of cells.
[Journal of Biomedical Materials Research Part B-Applied Biomaterials] |
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| Scientists outline a selection of the literature describing biological features of circulating tumor cells with an impact on their metastasis-forming ability in different gastrointestinal cancers.
[British Journal of Cancer] |
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| Researchers from the University of Sydney have been awarded $47 million to support 32 research projects, including investigations of younger-onset dementia, the treatment of blinding eye diseases through stem cell therapy, and the impact of e-cigarette use by adolescents.
[The University of Sydney] |
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| April 24, 2023
Chicago, Illinois, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Columbia University – New York, New York, United States |
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| | Amsterdam UMC – Amsterdam, Netherlands |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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