Cancer Stem Cell News Volume 12.11 | Mar 22 2023

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    2023-03-22 | CSCN 12.11


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.11 – 22 March, 2023
    TOP STORY

    IGFBP5 Is an ROR1 Ligand Promoting Glioblastoma Invasion via ROR1/HER2-CREB Signaling Axis

    Researchers reported Insulin-like Growth Factor-Binding Protein 5 (IGFBP5), a ligand for Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1), as a promising target for glioblastoma stem-like cell invasion.
    [Nature Communications]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Cancer-Associated Fibroblast-Derived miR-146a-5p Generates a Niche That Promotes Bladder Cancer Stemness and Chemoresistance

    To better understand the mechanisms involved in tumor microenvironment-mediated generation and support of urothelial bladder cancer CSCs, scientists focused on the role of cancer-associated fibroblasts.
    [Cancer Research]

    Abstract

    SREBP2 Maintains Glioblastoma Stem Cells through Keeping the Balance between Cholesterol Biosynthesis and Uptake

    In vitro and in vivo loss-of-function genetic and pharmacologic assays were conducted to evaluate the effect of Sterol Regulatory Element-Binding Protein 2 (SREBP2) on glioblastoma cholesterol biosynthesis, proliferation, and self-renewal.
    [Neuro-Oncology]

    Abstract

    Eliciting Effective Tumor Immunity against Ovarian Cancer by Cancer Stem Cell Vaccination

    Scientists evaluated the immune effects of CSCs vaccines on ovarian cancer (OC). The CD44+CD117+CSCs were isolated from human OC HO8910 and SKOV3 cells using the magnetic cell sorting system.
    [Biomedicine & Pharmacotherapy]

    Abstract

    Depleting DDX1 Sensitizes Non-Small Cell Lung Cancer Cells to Chemotherapy by Attenuating Cancer Stem Cell Traits

    The authors found that depleting DEAD-box helicase 1 (DDX1) increased the sensitivity of non-small cell lung cancer cells to the chemotherapy drug cisplatin, increased cell apoptosis, and inhibited cell migration and invasion.
    [Life Sciences]

    Abstract

    RHAMM Marks Proliferative Subpopulation of Human Colorectal Cancer Stem Cells

    Scientists investigated organoids, miniature forms of tumor tissues with reconstructing cellular diversity, to identify specific marker to characterize CSCs in heterogeneous tumors.
    [Cancer Science]

    Abstract

    Adipocytes Reprogram Prostate Cancer Stem Cell Machinery

    Researchers demonstrated that 3T3-L1 adipocyte conditioned media could endow PC3 and DU145 prostate cancer cells with stemness properties, by stimulating their sphere formation ability and promoting CD133 and CD44 expression.
    [Journal of Cell Communication and Signaling]

    Full ArticleGraphical Abstract

    Deciphering the Molecular Mechanism of the THBS1 Gene in the TNF Signaling Axis in Glioma Stem Cells

    To investigate the relevant molecular mechanism and signal pathway of glioma stem cell behavior mediated by thrombospondin 1 (THBS1), U251 astroglioma cells and glioma stem cells were taken as model cells for in vitro experiments.
    [Cellular Signalling]

    Abstract

    The Roles and Molecular Mechanisms of Long Non-Coding RNA WT1-AS in the Maintenance and Development of Gastric Cancer Stem Cells

    The authors showed that long non-coding RNA WT1 antisense RNA (WT1-AS) negatively regulated Wilms’ tumor 1 (WT1) expression in gastric CSCs.
    [Heliyon]

    Full Article

    Silicon Nanowire Array Overcomes Chemotherapeutic Resistance by Inducing the Differentiation of Breast Cancer Stem Cells

    Investigators reported the silicon nanowire array differentiated MCF-7-derived breast CSCs into non-CSCs by modulating the morphology of cells.
    [Journal of Biomedical Materials Research Part B-Applied Biomaterials]

    Abstract
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    REVIEWS

    Circulating Tumor Cells in Gastrointestinal Cancers: Food for Thought?

    Scientists outline a selection of the literature describing biological features of circulating tumor cells with an impact on their metastasis-forming ability in different gastrointestinal cancers.
    [British Journal of Cancer]

    Full Article
    INDUSTRY AND POLICY NEWS

    Sydney Researchers Awarded $47 Million for Medical Research

    Researchers from the University of Sydney have been awarded $47 million to support 32 research projects, including investigations of younger-onset dementia, the treatment of blinding eye diseases through stem cell therapy, and the impact of e-cigarette use by adolescents.
    [The University of Sydney]

    Press Release
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    April 24, 2023
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    JOB OPPORTUNITIES

    Staff Scientist – Molecular and Cellular

    Baylor College of Medicine – Houston, Texas, United States

    Associate Research Scientists – Cancer Genetics

    Columbia University – New York, New York, United States

    PhD – ECM in Cancer Development

    Amsterdam UMC – Amsterdam, Netherlands

    Staff Scientist – Pediatric Brain Tumors

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Fellow – Cancer and Neurodegenerative Diseases

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

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