 | | Vol. 12.12 – 28 March, 2023 |
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| Investigators identified circulating tumor cell biomarkers and effective combinations of tumor-initiating stem-like cell-specific, repurposed FDA-approved drugs.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported that terminally exhausted (TTEX) cells actively participated in tumor progression by modulating CSCs. TTEX cells strongly correlated with elevated CSC frequency in poorly immune-infiltrated advanced human breast and ovarian carcinomas.
[Cancer Research] |
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| Monodisperse hollow-structured MnO2 was successively modified with hyaluronic acid to enhance targeting CSCs with high CD44 expression levels.
[ACS Applied Materials & Interfaces] |
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| Investigators reported a novel derivative of lonidamine, namely HYL001, which selectively and potently inhibited CSCs by targeting mitochondria.
[Pharmacological Research] |
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| Scientists presented DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and in vivo for visualization diagnostics of central nervous system tumors.
[Molecular Therapy – Nucleic Acids] |
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| Harmine was identified as a hit compound based on phenotypic screening of a 2D assay and patient-derived organoid model that was established from a patient with multiple drug resistance and breast metastases.
[Cancer Letters] |
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| Researchers investigated the molecular and funcitonal makeup of ovarian CSCs (OCSCs) in clinically relevant model systems, and revealed that Matrix Gla Protein was markedly enriched in OCSCs.
[Cell Death & Disease] |
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| The authors investigated the effects of histone methyltransferases 2, EHMT2 or G9a, on immunosuppressive tumor microenvironment and whether this effect was related to changes on cell stemness.
[CNS Neuroscience & Therapeutics] |
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The in vitro and in vivo study demonstrated that tumor necrosis factor-α-induced protein-8-like-2 (TIPE2) sensitized breast cancer cells to paclitaxel by suppressing drug-induced autophagy and CSC properties.
[Human Cell] |
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| The authors summarize the biological hallmarks and markers of CSCs, and the nanotechnology-based therapies to eradicate them.
[Daru-Journal Of Pharmaceutical Sciences] |
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| The FDA outlined plans to move away from single-arm studies and instead favor randomized controlled trials that can potentially serve as the basis for both accelerated and full approval.
[Fierce Biotech] |
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| July 24 – 28, 2023
Boston, Massachusetts, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Columbia University – New York City, New York, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
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Hematopoiesis News
Hepatic Cell News
Human Immunology News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Umbilical & Placental Cell News
