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Vol. 12.13 – 5 April, 2023
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Using genetically engineered and carcinogen-induced mouse models of intestinal neoplasia, scientists observed that impaired differentiation was a conserved event preceding cancer development.
[Science Advances]
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PUBLICATIONSRanked by the impact factor of the journal
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The sialylated cancer IgG (SIA-cIgG)/c-Met/SOX2/SIA-cIgG signaling loop was highly active in stem-like cells from many epithelial cancers and was crucial for cancer stemness in vitro and in vivo.
[Cancer Research]
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Researchers observed that the expression of thymocyte-expressed, positive selection-associated 1 (Tespa1) was markedly increased in hematopoietic stem cells after stress exposure.
[Leukemia]
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Scientists described a unique translation regulatory axis enacted by reduced expression of miR-183 in breast CSCs, which they showed targeted the eIF2Bδ subunit of guanine nucleotide exchange factor eIF2B.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]
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Investigators developed a thiol-Michael addition injectable hydrogel further to capture glioblastoma/glioblastoma stem-like cells through CXCL12-mediated chemotaxis.
[Advanced Healthcare Materials]
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Researchers showed that post-oncolytic HSV (oHSV) virotherapy-activated AKT signaling results in an enrichment of glioblastoma stem-like cell signatures in glioma.
[Molecular Therapy Oncolytics]
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Investigators evaluated novel regulators of stem cell factor expression to identify novel therapeutic strategies that could target liver CSCs.
[International Journal Of Oncology]
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A soft agar colony formation assay using polymerase chain reaction method was applied to evaluate tumorigencitiy of cells in cellular therapy products.
[Scientific Reports]
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The authors established a novel approach to capture and cultivate circulating tumor cells (CTCs) using a microfilter device. Whole blood was filtered to isolate CTCs and cells captured on the microfilter were cultured in place.
[Oncology Reports]
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Scientists summarize the characteristic features and functional mechanisms of CSC-derived exosomes/mesenchymal stem cell exosomes/cancer-associated fibroblast exosomes and their mutual impact on cancer progression and therapy resistance.
[Biochimie]
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Merck announced that the US FDA has granted full approval to KEYTRUDA for the treatment of adult and pediatric patients with unresectable or metastatic MSI-H or dMMR solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment options.
[Merck]
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April 25 – 26, 2023
Boston, Massachusetts, United States
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University of Southern California – Los Angeles, California, United States
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University of Texas Health Science Center – San Antonio, Texas, United States
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Baylor College of Medicine – Houston, Texas, United States
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University of Pennsylvania – Philadelphia, Pennsylvania, United States
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Columbia University – New York, New York, United States
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Cancer Stem Cell News
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