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Vol. 12.14 – 12 April, 2023
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scRNA-seq was conducted on 95 551 cells from endoscopic biopsies of low-grade intraepithelial neoplasia, well/moderately/poorly differentiated early gastric cardia adenocarcinoma, and their paired adjacent nonmalignant biopsy samples.
[Gut]
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PUBLICATIONSRanked by the impact factor of the journal
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Single cell RNA sequencing of HPV16 infected compared to uninfected organoids identified 12 distinct keratinocyte populations, with a subset mapped to reconstruct their respective 3D geography in stratified squamous epithelium.
[Nature Communications]
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Researchers generated a genetically engineered mouse with prostate-specific expression of the ETS factor, ETV4, at lower and higher protein dosage through mutation of its degron.
[Science Advances]
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The authors investigated the alteration of glycosylation in colorectal cancer following long-term plasticizers exposure. They determined the profiles of cell surface N-glycomes by using mass spectrometry and found out the alterations of α2,8-linkages glycans.
[Environmental Pollution]
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CSCs and non-stem cancer cells were sorted from gastric cancer cells, and extracellular vesicles were isolated from CSCs.
[Journal of Translational Medicine]
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The serum concentration and intracellular expression level of stanniocalcin-1 (STC1) were quantified by ELISA and western blotting, respectively.
[Journal of Translational Medicine]
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In transcriptomic and protein expression analyses, scientists identified NOTCH1 signaling as one of the main pro-stemness pathways repressed by EC-8042 in osteosarcomas.
[Biomedicine & Pharmacotherapy]
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Researchers showed that Kruppel-like-factor 8 (KLF8) was required and sufficient for regulating CSC phenotypes and regulating transcription factors SOX2, NANOG, OCT4, and c-MYC.
[Frontiers In Oncology]
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DESeq2 was applied to analyze the differentially expressed genes. The mRNA stemness index was calculated by one-class logistic regression. The stemness-related cells were analyzed based on scRNA-seq dataset GSE166555.
[Cancer Medicine]
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The authors describe the structural features and functions of lysine demethylases (KDMs), the KDMs preferences of different cancers, and the mechanisms of drug resistance resulting from KDMs.
[Medicinal Research Reviews]
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Scientists review the biological features of gastric stem cells at various locations of the stomach under homeostatic conditions, as demonstrated by reporter mice, lineage tracing, and single cell sequencing.
[Cellular Oncology]
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Investigators highlight the properties of flavonoids particularly relevant for targeting breast CSCs to mitigate therapy resistance.
[Frontiers In Pharmacology]
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Oncolyze, which already holds an Orphan Drug Designation for its lead drug candidate OM-301 in treating acute myeloid leukemia, announced that the FDA has just granted OM-301 its second Orphan Drug Designation, for multiple myeloma.
[Oncolyze (Newswire)]
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April 30 – May 5, 2023
Barga, Italy
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STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada
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University of Southern California – Los Angeles, California, United States
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University of Texas Health Science Center – San Antonio, Texas, United States
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University of Pennsylvania – Philadelphia, Pennsylvania, United States
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Baylor College of Medicine – Houston, Texas, United States
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Cancer Stem Cell News
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