Cancer Stem Cell News Volume 12.14 | Apr 12 2023

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    2023-04-12 | CSCN 12.14


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.14 – 12 April, 2023
    TOP STORY

    NNMT Enriches for AQP5+ Cancer Stem Cells to Drive Malignant Progression in Early Gastric Cardia Adenocarcinoma

    scRNA-seq was conducted on 95 551 cells from endoscopic biopsies of low-grade intraepithelial neoplasia, well/moderately/poorly differentiated early gastric cardia adenocarcinoma, and their paired adjacent nonmalignant biopsy samples.
    [Gut]

    Abstract
    Find the Right Antibodies for Your Stem Cell Research. Learn More
    PUBLICATIONSRanked by the impact factor of the journal

    Single Cell Transcriptomic Analysis of HPV16-Infected Epithelium Identifies a Keratinocyte Subpopulation Implicated in Cancer

    Single cell RNA sequencing of HPV16 infected compared to uninfected organoids identified 12 distinct keratinocyte populations, with a subset mapped to reconstruct their respective 3D geography in stratified squamous epithelium.
    [Nature Communications]

    Full Article

    ETV4 Mediates Dosage-Dependent Prostate Tumor Initiation and Cooperates with p53 Loss to Generate Prostate Cancer

    Researchers generated a genetically engineered mouse with prostate-specific expression of the ETS factor, ETV4, at lower and higher protein dosage through mutation of its degron.
    [Science Advances]

    Full Article

    Long-Term DEHP/MEHP Exposure Promotes Colorectal Cancer Stemness Associated with Glycosylation Alterations

    The authors investigated the alteration of glycosylation in colorectal cancer following long-term plasticizers exposure. They determined the profiles of cell surface N-glycomes by using mass spectrometry and found out the alterations of α2,8-linkages glycans.
    [Environmental Pollution]

    AbstractGraphical Abstract

    LncRNA H19-Rich Extracellular Vesicles Derived from Gastric Cancer Stem Cells Facilitate Tumorigenicity and Metastasis via Mediating Intratumor Communication Network

    CSCs and non-stem cancer cells were sorted from gastric cancer cells, and extracellular vesicles were isolated from CSCs.
    [Journal of Translational Medicine]

    Full Article

    The Stromal-Tumor Amplifying STC1-Notch1 Feedforward Signal Promotes the Stemness of Hepatocellular Carcinoma

    The serum concentration and intracellular expression level of stanniocalcin-1 (STC1) were quantified by ELISA and western blotting, respectively.
    [Journal of Translational Medicine]

    Full Article

    Abrogation of Stemness in Osteosarcoma by the Mithramycin Analog EC-8042 Is Mediated by Its Ability to Inhibit NOTCH-1 Signaling

    In transcriptomic and protein expression analyses, scientists identified NOTCH1 signaling as one of the main pro-stemness pathways repressed by EC-8042 in osteosarcomas.
    [Biomedicine & Pharmacotherapy]

    Full Article

    Kruppel-Like Factor 8 Regulates Triple Negative Breast Cancer Stem Cell-Like Activity

    Researchers showed that Kruppel-like-factor 8 (KLF8) was required and sufficient for regulating CSC phenotypes and regulating transcription factors SOX2, NANOG, OCT4, and c-MYC.
    [Frontiers In Oncology]

    Abstract

    Role of Stemness-Related Genes TIMP1, PGF, and SNAI1 in the Prognosis of Colorectal Cancer through Single-Cell RNA-Seq

    DESeq2 was applied to analyze the differentially expressed genes. The mRNA stemness index was calculated by one-class logistic regression. The stemness-related cells were analyzed based on scRNA-seq dataset GSE166555.
    [Cancer Medicine]

    Full Article
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    REVIEWS

    The Role and Prospect of Lysine-Specific Demethylases in Cancer Chemoresistance

    The authors describe the structural features and functions of lysine demethylases (KDMs), the KDMs preferences of different cancers, and the mechanisms of drug resistance resulting from KDMs.
    [Medicinal Research Reviews]

    Abstract

    The Composition and Roles of Gastric Stem Cells in Epithelial Homeostasis, Regeneration, and Tumorigenesis

    Scientists review the biological features of gastric stem cells at various locations of the stomach under homeostatic conditions, as demonstrated by reporter mice, lineage tracing, and single cell sequencing.
    [Cellular Oncology]

    Abstract

    Therapy-Resistant Breast Cancer in Focus: Clinically Relevant Mitigation by Flavonoids Targeting Cancer Stem Cells

    Investigators highlight the properties of flavonoids particularly relevant for targeting breast CSCs to mitigate therapy resistance.
    [Frontiers In Pharmacology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Oncolyze Announces FDA Orphan Drug Designation for OM-301 for the Treatment of Multiple Myeloma

    Oncolyze, which already holds an Orphan Drug Designation for its lead drug candidate OM-301 in treating acute myeloid leukemia, announced that the FDA has just granted OM-301 its second Orphan Drug Designation, for multiple myeloma.
    [Oncolyze (Newswire)]

    Press Release
    FEATURED EVENT

    Understanding Cell Behavior and Communication

    April 30 – May 5, 2023
    Barga, Italy

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    JOB OPPORTUNITIES

    Specialist – StainsFile

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Postdoctoral Scholar – Immunotherapy for Glioblastoma

    University of Southern California – Los Angeles, California, United States

    Postdoctoral Position – Cancer Metabolism, Epigenetics, Hematopoiesis

    University of Texas Health Science Center – San Antonio, Texas, United States

    Postdoctoral Fellow – Tumor Suppressor p53

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Staff Scientist – Molecular and Cellular Mechanisms of Breast Cancer Initiation

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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