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| Using triple negative breast cancer as a model, researchers demonstrated that aNRP2-10 could be used to isolate CSCs from heterogeneous tumor populations and inhibit CSC function and epithelial-to-mesenchymal transition.
[Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| A multifunctional cascade bioreactor, based on the self-assembly of pH-responsive hydroxyethyl starch prodrugs, copper ions, and glucose oxidase, was engineered, empowered by hyperbaric oxygen for efficient cooperative therapy against aggressive breast cancers.
[Advanced Science] |
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| In a randomized clinical trial, the ChemoID assay, a personalized approach for selecting the most effective treatment from FDA-approved chemotherapies, improved the survival of patients with recurrent glioblastoma over physician-chosen chemotherapy.
[Cell Reports Medicine] |
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| Researchers
showed that a cellular subpopulation with partial epithelial-mesenchymal transition-like signature marked by high expression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) was the origin of heterogeneous tumor cells in pancreatic ductal adenocarcinoma.
[Embo Journal] |
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| Investigators showed that chitinase 3-like 1 (Chi3l1) altered the state of glioma stem cells (GSCs) to support tumor growth. Exposure of patient-derived GSCs to Chi3l1 reduced the frequency of CD133+SOX2+ cells and increased the CD44+Chi3l1+ cells.
[Cancer Research] |
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| The authors found that in advanced hepatocellular carcinoma tissues, collagen I was upregulated, which was consistent with the expression of its receptor DDR1. Collagen I-induced DDR1 activation enhanced HCC cell stemness in vitro and in vivo.
[Cell Death & Differentiation] |
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| Scientists tested if Musashi 2 (MSI2) promoted MYC and viral mRNA translation to induce self-renewal via an internal ribosome entry sequence.
[Cell Death Discovery] |
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| Functional studies showed that thioredoxin promoted hepatocellular carcinoma (HCC) stemness properties and facilitated HCC metastasis both in vitro and in vivo.
[FASEB Journal] |
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| Researchers found that dihydroartemisinin (DHA) inhibited cell viability in HCT116 and SW620 cells. Moreover, DHA decreased cell clonogenicity, and improved oxaliplatin sensitivity.
[Drug Development Research] |
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| Scientists searched for genes differentially expressed in circulating tumor cells (CTCs) by analyzing four CTCs and primary tumor gene expression datasets in the GEO database.
[Scientific Reports] |
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| Investigators detected the expression level of kinesin family member 15 (KIF15) in a microarray of endometrial cancer tissues by immunohistochemical staining and analyzed the correlation between the expression level of KIF15 and the pathological characteristics of patients.
[Environmental Toxicology] |
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| The authors introduce the roles played by mitochondria and related mechanisms in CSC stemness maintenance, metabolic transformation, and chemoresistance.
[Trends in Cell Biology] |
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| Scientists examine and highlight the long non-coding RNAs (lncRNAs) with their regulatory functions specific to CSCs. They discuss the difficulties and various methods involved in identifying lncRNAs that can play a particular role in regulating and maintaining CSCs.
[Biochimica Et Biophysica Acta-Reviews On Cancer] |
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| Investigators summarize the progress made so far in integrating hyperthermia therapy with existing modules of differentiation therapy.
[Clinical And Experimental Medicine] |
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| PharmaEssentia USA Corporation announced that the first patients are now being dosed in ECLIPSE PV, a Phase IIIb clinical study evaluating an accelerated dosing schedule for ropeginterferon alfa-2b-njft using a prefilled syringe for the treatment of adults with PV.
[PharmaEssentia (Business Wire)] |
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| May 4 – 7, 2023
Riviera Maya, Mexico |
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| | The National University of Singapore – Singapore, Singapore |
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| | Novartis – Cambridge, Massachusetts, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Wake Forest University – Winston Salem, North Carolina, United States |
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| | University of Texas Health Science Center – San Antonio, Texas, United States |
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