Cancer Stem Cell News Volume 12.19 | May 17 2023

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    2023-05-17 | CSCN 12.19


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.19 – 17 May, 2023
    TOP STORY

    KK-LC-1 as a Therapeutic Target to Eliminate ALDH+ Stem Cells in Triple Negative Breast Cancer

    Full Article
    Use ImmunoCult™ to differentiate mouse CD4+ cells to Tregs.
    PUBLICATIONSRanked by the impact factor of the journal

    p140Cap Inhibits β-Catenin in the Breast Cancer Stem Cell Compartment Instructing a Protective Anti-Tumor Immune Response

    Integrative transcriptomic and preclinical studies unraveled that p140Cap controlled an epistatic axis where, through the upstream inhibition of β-Catenin, it restricted tumorigenicity and self-renewal of tumor-initiating cells.
    [Nature Communications]

    Full Article

    Cancer-Associated Fibroblast–Derived miR-146a-5p Generates a Niche That Promotes Bladder Cancer Stemness and Chemoresistance

    To better understand the mechanisms involved in tumor microenvironment-mediated generation and support of urothelial bladder cancer CSCs, investigators focused on the role of cancer-associated fibroblasts in this study.
    [Cancer Research]

    Abstract
    Graphical Abstract

    Single-Cell Spatial Analysis Identifies Regulators of Brain Tumor–Initiating Cells

    Researchers performed spatial transcriptomic and single-cell analyses of the mouse and human glioblastomas (GBM) microenvironment to dissect the impact of distinct anatomical regions of brains on GBM.
    [Cancer Research]

    Abstract
    Graphical Abstract

    The PLOD2/Succinate Axis Regulates the Epithelial–Mesenchymal Plasticity and Cancer Cell Stemness

    Using stable isotope-resolved metabolomics analysis, the authors showed that the epithelial mesenchymal transition was associated with profound changes in metabolites, including elevation of cytoplasmic succinate levels.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    AbstractPress Release

    A Dual-Action Niclosamide-Based Prodrug That Targets Cancer Stem Cells and Inhibits TNBC Metastasis

    Investigators reported a prodrug, Nic-A that was designed to target triple-negative breast cancer (TNBC) CSCs and was found to inhibit both proliferating TNBC cells and CSCs via signal transducer and transcriptional activator 3 dysregulation and suppression of CSC-like properties.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    TIM-3 Signaling Hijacks the Canonical Wnt/β-Catenin Pathway to Maintain Cancer Stemness in Acute Myeloid Leukemia

    Researchers showed that the acute myeloid leukemia-specific autocrine loop comprised of T cell immunoglobulin mucin-3 (TIM-3) and its ligand, galectin-9, drove the canonical Wnt pathway to stimulate self-renewal and propagation of leukemic stem cells, independent of Wnt ligands.

    [Blood Advances]

    Abstract
    Graphical Abstract

    N6-Methyladenine-Mediated Aberrant Activation of the lncRNA SOX2OT-GLI1 Loop Promotes Non-Small-Cell Lung Cancer Stemness

    Scientists investigated the molecular mechanism of non-canonical aberrant glioma-associated oncogene homolog 1 (GLI1) upregulation. The SHH cascade was upregulated in stem spheres and chemo-resistant lung cancer cells.
    [Cell Death Discovery]

    Full Article

    Silencing Notch4 Promotes Tumorigenesis and Inhibits Metastasis of Triple-Negative Breast Cancer via Nanog and Cdc42

    Investigators explored the Notch4 function in triple-negative breast cancer (TNBC). They found that silencing Notch4 enhanced tumorigenic ability in TNBC cells via upregulating Nanog expression, a pluripotency factor of embryonic stem cells.
    [Cell Death Discovery]

    Full Article

    FGF-Trapping Hampers Cancer Stem-Like Cells in Uveal Melanoma

    Taking advantage from a pan Fibroblast Growth Factor (FGF)-trap molecule, the authors singled out and analyzed a Uveal Melanoma-Cancer stem-like cell subset with marked stem-like properties.
    [Cancer Cell International]

    Full Article

    CD168+ Macrophages Promote Hepatocellular Carcinoma Tumor Stemness and Progression through TOP2A/β-Catenin/YAP1 Axis

    Using single-cell RNA-seq analysis, scientists identified TOP2A+CENPF+ liver cancer stem-like cells, which were mainly regulated by CD168+ M2-like macrophages.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    ALDH2 Promotes Cancer Stemness and Metastasis in Colorectal Cancer through Activating β-Catenin Signaling

    Researchers investigated the role of aldehyde dehydrogenase 2 (ALDH2) in colorectal cancer progression by targeting its enzymatic activity rather than gene expression.
    [Journal of Cellular Biochemistry]

    Abstract
    Cell Preparation For Crossmatch Assays
    REVIEWS

    Pancreatic Cancer Stemness: Dynamic Status in Malignant Progression

    The authors summarize current knowledge of pancreatic CSCs from an oncology perspective, discuss developments in the field of pancreatic CSCs and, more importantly, focus on elucidating that pancreatic CSCs exist as a plastic state.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Long Non-Coding RNAs in Breast Cancer Stem Cells

    Investigators summarize recent studies that highlight the role of long non-coding RNAs in tumor occurrence and progression through breast CSCs.
    [Medical Oncology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Sanford Stem Cell Institute to Study Cancer Stem Cell Targeted Therapy in Space

    In an effort to improve treatments for patients on Earth by better understanding how cancer spreads, a team of researchers is sending cancer organoids to space in an investigation sponsored by the International Space Station National Laboratory.
    [International Space Station National Laboratory]

    Press Release

    Dr. David Simon Wins Pershing Square Sohn Prize for Young Investigators in Cancer Research Studying Melanoma

    Dr. David Simon, the Fernholz Foundation Research Scholar in Neuroscience and an assistant professor of biochemistry at Weill Cornell Medicine, was awarded the 2023 Pershing Square Sohn Prize for Young Investigators in Cancer Research.
    [Weill Cornell Medicine]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Research Coordinator – Neuro-Oncology

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Cancer Research

    Guangzhou Medical University – Guangdong, China

    Postdoctoral Fellow – Oncology and Immunology

    Centre for Oncology and Immunology – Hong Kong

    Research Fellow – Aging and Cancer Stem Cell

    The National University of Singapore – Singapore, Singapore

    Postdoctoral Research Associate – Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    > See All Jobs

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