 | | Vol. 12.19 – 17 May, 2023 |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Integrative transcriptomic and preclinical studies unraveled that p140Cap controlled an epistatic axis where, through the upstream inhibition of β-Catenin, it restricted tumorigenicity and self-renewal of tumor-initiating cells.
[Nature Communications] |
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| To better understand the mechanisms involved in tumor microenvironment-mediated generation and support of urothelial bladder cancer CSCs, investigators focused on the role of cancer-associated fibroblasts in this study.
[Cancer Research] |
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| Researchers performed spatial transcriptomic and single-cell analyses of the mouse and human glioblastomas (GBM) microenvironment to dissect the impact of distinct anatomical regions of brains on GBM.
[Cancer Research] |
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| Using stable isotope-resolved metabolomics analysis, the authors showed that the epithelial mesenchymal transition was associated with profound changes in metabolites, including elevation of cytoplasmic succinate levels.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators reported a prodrug, Nic-A that was designed to target triple-negative breast cancer (TNBC) CSCs and was found to inhibit both proliferating TNBC cells and CSCs via signal transducer and transcriptional activator 3 dysregulation and suppression of CSC-like properties.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers showed that the acute myeloid leukemia-specific autocrine loop comprised of T cell immunoglobulin mucin-3 (TIM-3) and its ligand, galectin-9, drove the canonical Wnt pathway to stimulate self-renewal and propagation of leukemic stem cells, independent of Wnt ligands.
[Blood Advances] |
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| Scientists investigated the molecular mechanism of non-canonical aberrant glioma-associated oncogene homolog 1 (GLI1) upregulation. The SHH cascade was upregulated in stem spheres and chemo-resistant lung cancer cells.
[Cell Death Discovery] |
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| Investigators explored the Notch4 function in triple-negative breast cancer (TNBC). They found that silencing Notch4 enhanced tumorigenic ability in TNBC cells via upregulating Nanog expression, a pluripotency factor of embryonic stem cells.
[Cell Death Discovery] |
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| Taking advantage from a pan Fibroblast Growth Factor (FGF)-trap molecule, the authors singled out and analyzed a Uveal Melanoma-Cancer stem-like cell subset with marked stem-like properties.
[Cancer Cell International] |
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| Using single-cell RNA-seq analysis, scientists identified TOP2A+CENPF+ liver cancer stem-like cells, which were mainly regulated by CD168+ M2-like macrophages.
[iScience] |
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| Researchers investigated the role of aldehyde dehydrogenase 2 (ALDH2) in colorectal cancer progression by targeting its enzymatic activity rather than gene expression.
[Journal of Cellular Biochemistry] |
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| The authors summarize current knowledge of pancreatic CSCs from an oncology perspective, discuss developments in the field of pancreatic CSCs and, more importantly, focus on elucidating that pancreatic CSCs exist as a plastic state.
[Journal of Experimental & Clinical Cancer Research] |
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| Investigators summarize recent studies that highlight the role of long non-coding RNAs in tumor occurrence and progression through breast CSCs.
[Medical Oncology] |
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| In an effort to improve treatments for patients on Earth by better understanding how cancer spreads, a team of researchers is sending cancer organoids to space in an investigation sponsored by the International Space Station National Laboratory.
[International Space Station National Laboratory] |
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| Dr. David Simon, the Fernholz Foundation Research Scholar in Neuroscience and an assistant professor of biochemistry at Weill Cornell Medicine, was awarded the 2023 Pershing Square Sohn Prize for Young Investigators in Cancer Research.
[Weill Cornell Medicine] |
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| June 2 – 6, 2023
Chicago, Illinois, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Guangzhou Medical University – Guangdong, China |
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| | Centre for Oncology and Immunology – Hong Kong |
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| | The National University of Singapore – Singapore, Singapore |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
