Cancer Stem Cell News Volume 12.23 | Jun 14 2023


    2023-06-15 | CSCN 12.23

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.23 – 14 June, 2023

    LIMP-2 Enhances Cancer Stem-Like Cell Properties by Promoting Autophagy-Induced GSK3β Degradation in Head and Neck Squamous Cell Carcinoma

    The authors identified a candidate gene named LIMP-2 as a novel therapeutic target regulating head and neck squamous cell carcinoma (HNSCC) progression and CSC properties. The high expression of LIMP-2 in HNSCC patients suggested a poor prognosis and potential immunotherapy resistance.
    [International Journal Of Oral Science]

    Full Article
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
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    YY2-DRP1 Axis Regulates Mitochondrial Fission and Determines Cancer Stem Cell Asymmetric Division

    It was shown that ying yang 2 (YY2) was downregulated in stem-like tumor spheres formed by hepatocarcinoma cells and in liver cancer, in which its expression was negatively correlated with disease progression and poor prognosis.
    [Advanced Science]

    Full Article

    Targeting Transglutaminase 2 Mediated Exostosin Glycosyltransferase 1 Signaling in Liver Cancer Stem Cells with Acyclic Retinoid

    Investigators examined the subcellular location-dependent effects of acyclic retinoid on transglutaminase 2 (TG2) activity at a structural level and characterized the functional role of TG2 and its downstream molecular mechanism in the selective depletion of liver CSCs.
    [Cell Death & Disease]

    Full ArticleGraphical Abstract

    USP8 Positively Regulates Hepatocellular Carcinoma Tumorigenesis and Confers Ferroptosis Resistance through β-Catenin Stabilization

    Researchers identified novel modulators in controlling β-catenin ubiquitination and stability. USP8 was overexpressed in hepatocellular carincoma tissues and correlated with β-catenin protein level.
    [Cell Death & Disease]

    Full Article

    Exosomal miR-6733-5p Mediates Cross-Talk Between Glioblastoma Stem Cells and Macrophages and Promotes Glioblastoma Multiform Progression Synergistically

    Glioblastoma stem cells (GSCs)-derived exosomal miR-6733-5p induced macrophage M2 polarization of tumor-associated macrophages by positively targeting IGF2BP3 to activate the AKT signaling pathway, which further facilitated the self-renewal and stemness of GSCs.
    [CNS Neuroscience & Therapeutics]

    Full Article

    Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-Like and Mesenchymal Programs

    Scientists found that Oncostatin-M uniquely induced tumor-initiation and gemcitabine resistance independently of its ability to induce a CD44HI/mesenchymal phenotype.
    [Molecular Cancer Research]


    An Adhesion-Based Method for Rapid and Low-Cost Isolation of Circulating Tumor Cells

    Researchers developed a new method based on the stronger adhesive power of circulating tumor cells (CTCs) versus leukocytes to sensitively isolate CTCs. Using a BSA-coated microplate and low-speed centrifuge, this method could easily separate cancer cells within 20 minutes at a very low cost.
    [Clinica Chimica Acta]


    Melatonin Regulates Cancer Migration and Stemness and Enhances the Anti-Tumor Effect of Cisplatin

    Melatonin inhibited gastric cancer cell migration and soft agar colony formation. Magnetic-activated cell sorting was applied to isolate CD133+ cancer stem cells.
    [Journal Of Cellular And Molecular Medicine]

    Full Article

    Circular RNA circBNC2 Facilitates Glycolysis and Stemness of Hepatocellular Carcinoma Through the miR-217/High Mobility Group AT-Hook 2 (HMGA2) Axis

    Upregulation of circBNC2 was related to poor prognosis and tumor node metastasis stage. Knockdown of circBNC2 inhibited the hepatocellular cancer progression. Moreover, knockdown of circBNC2 suppressed the levels of Ras, ERK1/2, PCNA, HK2, and OCT4.

    Full Article

    Silicon Nanowire Array Overcomes Chemotherapeutic Resistance by Inducing the Differentiation of Breast Cancer Stem Cells

    Investigators reported the SiNWA differentiates MCF-7-derived breast CSCs (BCSCs) into non-CSCs by modulating the morphology of cells. In vitro, the differentiated BCSCs lost the stemness properties and thus became sensitive to chemotherapeutic drugs, eventually leading to the death of BCSCs.
    [Journal Of Biomedical Materials Research Part B-Applied Biomaterials]

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    Therapeutic Implications of Cancer Stem Cells in Prostate Cancer

    The authors discuss the origin, hierarchy, and plasticity of prostate cancer stem cells (PCSCs) and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance.
    [Cancer Biology & Medicine]

    Full Article

    OICR Funding to Help Six Ontario-Based Research Teams Improve the Lives of Cancer Patients

    Funding announced by the Ontario Institute for Cancer Research (OICR) will help six Ontario-based research teams pursue their ultimate goal of improving the lives of people with cancer.
    [News Medical Life Sciences]

    Press Release

    Biochemist Receives MIRA Award to Conduct Work to Better Understand Stem Cell Biology

    Dr. Benjamin Martin, Associate Professor at Stony Brook University has received a $2 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to conduct research to understand the molecular and cell biology of neuromesodermal progenitors.
    [Stony Brook University]

    Press Release

    Cell Therapy Analytics Symposium

    September 19, 2023

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    Research Associate – Cancer Research

    VIB-UGent Center for Medical Biotechnology – Ghent, Belgium

    Research Fellow – Cancer Immunotherapy

    University College London – London, England, United Kingdom

    Postdoctoral Fellow – Genitourinary Medical Oncology Research

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Research Associate – Healthy & Mutant Blood Stem Cells

    The University of New South Wales – Sydney, Australia

    Postdoctoral Position – Cancer Immunology

    Institut Pasteur – Paris, France

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