 | | Vol. 12.23 – 14 June, 2023 |
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| The authors identified a candidate gene named LIMP-2 as a novel therapeutic target regulating head and neck squamous cell carcinoma (HNSCC) progression and CSC properties. The high expression of LIMP-2 in HNSCC patients suggested a poor prognosis and potential immunotherapy resistance.
[International Journal Of Oral Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| It was shown that ying yang 2 (YY2) was downregulated in stem-like tumor spheres formed by hepatocarcinoma cells and in liver cancer, in which its expression was negatively correlated with disease progression and poor prognosis.
[Advanced Science] |
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| Investigators examined the subcellular location-dependent effects of acyclic retinoid on transglutaminase 2 (TG2) activity at a structural level and characterized the functional role of TG2 and its downstream molecular mechanism in the selective depletion of liver CSCs.
[Cell Death & Disease] |
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| Researchers identified novel modulators in controlling β-catenin ubiquitination and stability. USP8 was overexpressed in hepatocellular carincoma tissues and correlated with β-catenin protein level.
[Cell Death & Disease] |
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| Glioblastoma stem cells (GSCs)-derived exosomal miR-6733-5p induced macrophage M2 polarization of tumor-associated macrophages by positively targeting IGF2BP3 to activate the AKT signaling pathway, which further facilitated the self-renewal and stemness of GSCs.
[CNS Neuroscience & Therapeutics] |
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| Scientists found that Oncostatin-M uniquely induced tumor-initiation and gemcitabine resistance independently of its ability to induce a CD44HI/mesenchymal phenotype.
[Molecular Cancer Research] |
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| Researchers developed a new method based on the stronger adhesive power of circulating tumor cells (CTCs) versus leukocytes to sensitively isolate CTCs. Using a BSA-coated microplate and low-speed centrifuge, this method could easily separate cancer cells within 20 minutes at a very low cost.
[Clinica Chimica Acta] |
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| Melatonin inhibited gastric cancer cell migration and soft agar colony formation. Magnetic-activated cell sorting was applied to isolate CD133+ cancer stem cells.
[Journal Of Cellular And Molecular Medicine] |
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| Upregulation of circBNC2 was related to poor prognosis and tumor node metastasis stage. Knockdown of circBNC2 inhibited the hepatocellular cancer progression. Moreover, knockdown of circBNC2 suppressed the levels of Ras, ERK1/2, PCNA, HK2, and OCT4.
[Heliyon] |
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| Investigators reported the SiNWA differentiates MCF-7-derived breast CSCs (BCSCs) into non-CSCs by modulating the morphology of cells. In vitro, the differentiated BCSCs lost the stemness properties and thus became sensitive to chemotherapeutic drugs, eventually leading to the death of BCSCs.
[Journal Of Biomedical Materials Research Part B-Applied Biomaterials] |
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| The authors discuss the origin, hierarchy, and plasticity of prostate cancer stem cells (PCSCs) and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance.
[Cancer Biology & Medicine] |
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| Funding announced by the Ontario Institute for Cancer Research (OICR) will help six Ontario-based research teams pursue their ultimate goal of improving the lives of people with cancer.
[News Medical Life Sciences] |
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| Dr. Benjamin Martin, Associate Professor at Stony Brook University has received a $2 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to conduct research to understand the molecular and cell biology of neuromesodermal progenitors.
[Stony Brook University] |
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| September 19, 2023
Virtual |
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| | VIB-UGent Center for Medical Biotechnology – Ghent, Belgium |
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| | University College London – London, England, United Kingdom |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | The University of New South Wales – Sydney, Australia |
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| | Institut Pasteur – Paris, France |
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