 | | Vol. 12.24 – 21 June, 2023 |
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| Through high-resolution genome-wide single-cell DNA methylation sequencing, scientists identified 40 core domains that were uniformly hypomethylated from the earliest detectable stages of prostate malignancy through metastatic circulating tumor cells.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers integrated single-cell RNA-seq and functional validation to show that asymmetric division of colorectal cancer stem-like cells is critical for early intratumor heterogeneity establishment.
[EMBO Reports] |
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| Investigators comprehensively documented the stem-like capacities of seven in-use pediatric glioma cell cultures using parallel in vitro assays assessing stem cell-related protein expression, multipotency, self-renewal and proliferation/quiescence, and in vivo investigation of their tumorigenicity and invasiveness.
[Acta Neuropathologica Communications] |
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| Scientists studied the key active ingredients and corresponding target proteins in Huang-Lian-Jie-Du-Tang against BCR-ABL1-independent chronic myeloid leukemia (CML) resistance to therapeutics, and then explored its mechanism of against CML drug resistance.
[Phytomedicine] |
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| How neoplastic transformation occurs in normal neural projenitor cells (NPCs) and the role of the Ras/Raf/MAPK pathway in NPC transformation is unclear. Investigators generated NPCs from human embryonic stem cells carrying gene alterations in the Ras/Raf/MAPK pathway.
[International Journal Of Oncology] |
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| The authors identified epigenetic modifications involved in the control of the Wnt/β-catenin signaling and investigate the role of this pathway in the accumulation of CSC and chemoresistance of head and neck squamous cell carcinoma.
[Cellular Signalling] |
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| LASSO and Cox regression were applied based on sequencing information to construct a model of lung adenocarcinoma, which was validated to be robust.
[BMC Bioinformatics] |
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| The use of a convolutional neural network‑based artificial intelligence for circulating tumor cell detection was assessed using KYSE esophageal squamous cell carcinoma (ESCC) cell lines and blood samples from patients with ESCC.
[Oncology Letters] |
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| Investigators focused on some of these mechanisms of CSCs, paving the way for a better understanding of their regulatory mechanisms and developing platforms for targeted therapies.
[Cell Communication And Signaling] |
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| Cancer patients are facing an alarming shortage of critical chemotherapy drugs, forcing oncologists to ration cancer treatment doses for patients with curable diseases.
[STAT] |
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| Two clinical trials have been paused within the past two days because six participants– including one child– have died, according to reports by the drug companies. The two trials were unrelated: They were in different stages and testing therapies. But both were testing new cancer treatments.
[CNN] |
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| September 21 – 23, 2023
New York, New York, United States |
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| | University of Texas Health Science Center San Antonio – San Antonio, Texas, United States |
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| | Pfizer, Inc. – Southern California, United States |
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| | VIB Center for Cancer Biology – Leuven, Belgium |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | The University of New South Wales – Sydney, Australia |
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