Cancer Stem Cell News Volume 12.24 | Jun 21 2023

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    2023-06-21 | CSCN 12.24


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.24 – 21 June, 2023
    TOP STORY

    DNA Hypomethylation Silences Anti-Tumor Immune Genes in Early Prostate Cancer and CTCs

    Through high-resolution genome-wide single-cell DNA methylation sequencing, scientists identified 40 core domains that were uniformly hypomethylated from the earliest detectable stages of prostate malignancy through metastatic circulating tumor cells.
    [Cell]

    Full ArticleGraphical Abstract
    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    PUBLICATIONSRanked by the impact factor of the journal

    Targeting Intratumor Heterogeneity Suppresses Colorectal Cancer Chemoresistance and Metastasis

    Researchers integrated single-cell RNA-seq and functional validation to show that asymmetric division of colorectal cancer stem-like cells is critical for early intratumor heterogeneity establishment.
    [EMBO Reports]

    AbstractGraphical Abstract

    Comprehensive Profiling of Stem-Like Features in Pediatric Glioma Cell Cultures and Their Relation to the Subventricular Zone

    Investigators comprehensively documented the stem-like capacities of seven in-use pediatric glioma cell cultures using parallel in vitro assays assessing stem cell-related protein expression, multipotency, self-renewal and proliferation/quiescence, and in vivo investigation of their tumorigenicity and invasiveness.
    [Acta Neuropathologica Communications]

    Full Article

    System Analysis of Huang-Lian-Jie-Du-Tang and Their Key Active Ingredients for Overcoming CML Resistance by Suppression of Leukemia Stem Cells

    Scientists studied the key active ingredients and corresponding target proteins in Huang-Lian-Jie-Du-Tang against BCR-ABL1-independent chronic myeloid leukemia (CML) resistance to therapeutics, and then explored its mechanism of against CML drug resistance.
    [Phytomedicine]

    AbstractGraphical Abstract

    Activated KRAS Reprograms Neural Progenitor Cells to Glioma Stem Cell-Like Phenotype

    How neoplastic transformation occurs in normal neural projenitor cells (NPCs) and the role of the Ras/Raf/MAPK pathway in NPC transformation is unclear. Investigators generated NPCs from human embryonic stem cells carrying gene alterations in the Ras/Raf/MAPK pathway.
    [International Journal Of Oncology]

    Abstract

    Interplay Between EZH2/β-Catenin in Stemness of Cisplatin-Resistant HNSCC and Their Role As Therapeutic Targets

    The authors identified epigenetic modifications involved in the control of the Wnt/β-catenin signaling and investigate the role of this pathway in the accumulation of CSC and chemoresistance of head and neck squamous cell carcinoma.
    [Cellular Signalling]

    Abstract

    Endoplasmic Reticulum Stress-Related Gene Model Predicts Prognosis and Guides Therapies in Lung Adenocarcinoma

    LASSO and Cox regression were applied based on sequencing information to construct a model of lung adenocarcinoma, which was validated to be robust.
    [BMC Bioinformatics]

    Full Article

    The Use of an Artificial Intelligence Algorithm for Circulating Tumor Cell Detection in Patients with Esophageal Cancer

    The use of a convolutional neural network‑based artificial intelligence for circulating tumor cell detection was assessed using KYSE esophageal squamous cell carcinoma (ESCC) cell lines and blood samples from patients with ESCC.
    [Oncology Letters]

    Full Article
    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    REVIEWS

    The Role of Tumor Microenvironment on Cancer Stem Cell Fate in Solid Tumors

    Investigators focused on some of these mechanisms of CSCs, paving the way for a better understanding of their regulatory mechanisms and developing platforms for targeted therapies.
    [Cell Communication And Signaling]

    Full Article
    INDUSTRY AND POLICY NEWS

    Cancer Drug Shortages Should Have Patients Rioting in the Streets

    Cancer patients are facing an alarming shortage of critical chemotherapy drugs, forcing oncologists to ration cancer treatment doses for patients with curable diseases.
    [STAT]

    Press Release

    Two Cancer Drug Trials Put on Hold After Patients Died, Companies Say

    Two clinical trials have been paused within the past two days because six participants– including one child– have died, according to reports by the drug companies. The two trials were unrelated: They were in different stages and testing therapies. But both were testing new cancer treatments.
    [CNN]

    Press Release
    FEATURED EVENT

    Great Debates & Updates | Lung Cancers

    September 21 – 23, 2023
    New York, New York, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Cancer Metabolism & Epigenetics & Hematopoiesis Research

    University of Texas Health Science Center San Antonio – San Antonio, Texas, United States

    Director – Field Medical for GI/Skin/Lung Oncology

    Pfizer, Inc. – Southern California, United States

    Group Leader – Cancer Immunology

    VIB Center for Cancer Biology – Leuven, Belgium

    Postdoctoral Fellow – Genitourinary Medical Oncology Research

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Research Associate – Healthy & Mutant Blood Stem Cells

    The University of New South Wales – Sydney, Australia

    > See All Jobs

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