Cancer Stem Cell News Volume 12.25 | Jun 28 2023

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    2023-06-28 | CSCN 12.25


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.25 – 28 June, 2023
    TOP STORY

    A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy

    Investigators demonstrated a previously unrecognized form of pathogenesis characterized by monocytic disease progression arose from a fundamentally different type of leukemia stem cell (LSC) that was developmentally and clinically distinct from the more well-described primitive LSC.
    [Cancer Discovery]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Extracellular Matrix-Derived Mechanical Force Governs Breast Cancer Cell Stemness and Quiescence Transition Through Integrin-DDR Signaling

    Scientists explored the influence of extracellular matrix-derived biomechanical force on breast cancer cell status. Experiments were conducted using 3D collagen, fibrinogen, and Matrigel matrices to investigate the role of mechanical force in tumor development.
    [Signal Transduction And Targeted Therapy]

    Full Article

    Near-Infrared-Activated Anticancer Platinum(IV) Complexes Directly Photooxidize Biomolecules in an Oxygen-Independent Manner

    The authors reported the use of near-infrared-activated small-molecule Pt(IV) photooxidants to directly oxidize intracellular biomolecules in an oxygen-independent manner, achieving controllable and effective elimination of CSCs.
    [Nature Chemistry]

    AbstractGraphical Abstract

    Phase I Study of Acalabrutinib Plus Danvatirsen (AZD9150) in Relapsed/Refractory Diffuse Large B Cell Lymphoma Including Circulating Tumor DNA Biomarker Assessment

    Final results of the Phase I study of acalabrutinib plus STAT3 inhibitor in patients with R/R DLBCL awere reported. Danvatirsen 200 mg intravenous infusion was administered in combination with oral acalabrutinib 100 mg twice daily until progressive disease or unacceptable toxicity.
    [Clinical Cancer Research]

    Abstract

    Control of SOX2 Protein Stability and Tumorigenic Activity by E3 Ligase CHIP in Esophageal Cancer Cells

    The authors identified CHIP, a chaperone-associated ubiquitin E3 ligase, as a novel negative regulator of SOX2 protein stability and tumorigenic activity in esophageal squamous carcinoma cells.
    [Oncogene]

    AbstractGraphical Abstract

    Solasonine Inhibits Cancer Stemness and Metastasis by Modulating Glucose Metabolism via Wnt/β-Catenin/Snail Pathway in Osteosarcoma

    Researchers investigated the impact of solasonine (SS) on the growth of osteosarcoma (OS) cells. OS cells were treated with different concentrations of SS for 24 hours, and the results showed that SS attenuated the survival of OS cells in a dose-dependent manner.
    [American Journal Of Chinese Medicine]

    Abstract

    ZEB1 Potentiates Chemoresistance in Breast Cancer Stem Cells by Evading Apoptosis

    In silico analysis revealed a higher ZEB1 expression in breast cancer patients that led to decreased overall and relapse-free survival. Scientists generated sorted breast CSC with stable ZEB1 overexpression and/or silencing as well as breast cancer cells with stable ZEB1 overexpression and/or silencing
    [Biochimica Et Biophysica Acta-Molecular Cell Research]

    Full ArticleGraphical Abstract

    5-Aminolevulinic Acid Increases Boronophenylalanine Uptake into Glioma Stem Cells and May Sensitize Malignant Glioma to Boron Neutron Capture Therapy

    Researchers investigated whether the amino acid 5-aminolevulinic acid could sensitize glioma stem cells to boron neutron capture therapy by enhancing the uptake of boronophenylalanine.
    [Scientific Reports]

    Full Article

    Modeling the Novel SERD Elacestrant in Cultured Fulvestrant-Refractory HR-Positive Breast Circulating Tumor Cells

    The authors analyzed clinical outcomes with elacestrant, compared with endocrine therapy, among women who had previously been treated with a fulvestrant-containing regimen from the recent Phase III EMERALD Study.
    [Breast Cancer Research And Treatment]

    Full Article
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    REVIEWS

    GDF11 as a Friend or an Enemy in the Cancer Biology?

    GDF11 is a crucial factor in embryogenesis, cell cycle control and apoptosis, inasmuch it mainly targets cell retain stemness features, managing to the cell differentiation and the maturation.
    [Biochimica Et Biophysica Acta-Reviews On Cancer]

    Full ArticleGraphical Abstract

    Cancer Stem Cell Fate Determination: Mito-Nuclear Communication

    Investigators review recent progress on the influence of mitochondria on CSC potential from four aspects: metabolism, dynamics, mitochondrial homeostasis, and reactive oxygen species.
    [Cell Communication And Signaling]

    Full Article
    INDUSTRY AND POLICY NEWS

    A Blow to Cancer Research in the UK As National Cancer Institute Closes Down

    The UK’s National Cancer Research Institute (NCRI) has begun winding down operations and working on identifying and securing assets. The NCRI reported that it was becoming increasingly “unsustainable” to continue to fund the charitable organisation.
    [Clinical Trial Arena]

    Press Release

    Cancer Researcher Dr. Ly Vu Receives Funding from Program Challenging Gender Disparities

    This new granting program, developed by the V Foundation for Cancer Research, sees $8 million in funding invested in cancer research being led by women scientists. Dr. Vu is an associate assistant professor in the faculty of medicine and an assistant professor in the faculty of pharmaceutical sciences at UBC.
    [The University of British Columbia]

    Press Release
    FEATURED EVENT

    5th TIL Therapies Summit

    October 2 – 4, 2023
    Boston, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Scientist – Cancer Immunotherapy

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    Postdoctoral Fellowship – Tumor Metastasis

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Professor – Hematology & Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Position – Cancer Metabolism & Epigenetics & Hematopoiesis Research

    University of Texas Health Science Center San Antonio – San Antonio, Texas, United States

    Director – Field Medical for GI/Skin/Lung Oncology

    Pfizer, Inc. – Southern California, United States

    > See All Jobs

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