 | | Vol. 12.26 – 5 July, 2023 |
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| Hepatocyte-specific Uhrf1 knockout (Uhrf1HKO) strongly suppressed tumor initiation and CSC self-renewal in both diethylnitrosamine (DEN)/CCl4-induced and Myc-transgenic hepatocellular carcinoma mouse models.
[Cell Death & Disease] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors explored the potential role of KDM1A targeting in colorectal cancer (CRC) by characterizing the effect of KDM1A silencing in differentiated and CRC stem cells. I.
[Cell Death Discovery] |
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| The stiffness of bladder cancer cells was determined by atomic force microscopy. The modified microfluidic chip was utilized to separate soft cells, and the 3D Matrigel culture system was to maintain the softness of tumor cells.
[Chinese Medical Journal] |
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| Human colorectal cancer cell lines HCT116 and HT29 were transfected with RPL27‑specific small interfering RNA and proliferation was assessed in vitro and in vivo using proliferation assays, fluorescence‑activated cell sorting and a xenograft mouse model.
[International Journal Of Oncology] |
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| Researchers reported pathological expression of HML-2 in malignant gliomas in both cerebrospinal fluid and tumor tissue that was associated with a cancer stem cell phenotype and poor outcomes.
[European Journal Of Clinical Investigation] |
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| Scientists reported the synthesis, characterization, and anti-breast CSC properties of a series of copper(II)-terpyridine complexes containing aryl sulfonamide groups. All of the copper(II)-terpyridine complexes adopt distorted square pyramidal geometries and are suitably stable in biologically relevant solutions.
[Dalton Transactions] |
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| Researchers evaluated the expression levels of GNPNAT1 in breast cancer (BC) and its effect on BC stem cells. The Cancer Genome Atlas database was used for the analysis of the expression of GNPNAT1 and its clinical significance.
[Oncology Reports] |
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| Using the Cancer Genome Atlas database, investigators found higher expression of PTHrP in GBM, which correlated inversely with survival. Glioblastoma stem cells were established from three human glioblastoma samples obtained after surgical resection.
[International Journal Of Stem Cells] |
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| To describe the effects of a differentiating agent that reprograms CSCs into differentiated cancer cells (DCC), researchers adapted a differential equation model developed to investigate tumorspheres, which were assumed to consist of jointly evolving CSC and DCC populations
[Journal Of Theoretical Biology] |
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| Investigators classify regulators of cancer into three categories based on scale: tumor-cell-intrinsic, tissue-microenvironment, and organism-level sources.
[Nature Reviews Bioengineering] |
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| Scientists summarize recent findings regarding the role of histone modifiers in the development of drug-resistant cancer cells from the perspectives of CSCs and immune evasion.
[Experimental & Molecular Medicine] |
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| CANbridge Pharmaceuticals, Inc. announced that, based on the interim analysis recommendation of the independent data monitoring committee, it plans to continue the ongoing Phase II study of CAN008 in patients with newly diagnosed glioblastoma multiforme in China to completion.
[CANbridge Pharmaceuticals, Inc.] |
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| OSE Immunotherapeutics SA announced that the United States Patent and Trademark Office has granted a new patent protecting Tedopi®, a therapeutic cancer vaccine treating HLA-A2 positive patients after secondary resistance to PD-1/PD-L1 immune checkpoint inhibitor treatment.
[OSE Immunotherapeutics] |
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| August 6 – 11, 2023
Newry, Maine, United States |
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| | Umeå University – Umeå, Sweden |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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Cancer Stem Cell News
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