Cancer Stem Cell News Volume 12.26 | Jul 5 2023

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    2023-07-05 | CSCN 12.26


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.26 – 5 July, 2023
    TOP STORY

    UHRF1 Inhibition Epigenetically Reprograms Cancer Stem Cells to Suppress the Tumorigenic Phenotype of Hepatocellular Carcinoma

    Hepatocyte-specific Uhrf1 knockout (Uhrf1HKO) strongly suppressed tumor initiation and CSC self-renewal in both diethylnitrosamine (DEN)/CCl4-induced and Myc-transgenic hepatocellular carcinoma mouse models.
    [Cell Death & Disease]

    Full Article
    How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU
    PUBLICATIONSRanked by the impact factor of the journal

    Targeting Lysine-Specific Demethylase 1 (KDM1A/LSD1) Impairs Colorectal Cancer Tumorigenesis by Affecting Cancer Cells Stemness, Motility, and Differentiation

    The authors explored the potential role of KDM1A targeting in colorectal cancer (CRC) by characterizing the effect of KDM1A silencing in differentiated and CRC stem cells. I.
    [Cell Death Discovery]

    Full Article

    Cell Softness Reveals Tumorigenic Potential via ITGB8/AKT/Glycolysis Signaling in a Mice Model of Orthotopic Bladder Cancer

    The stiffness of bladder cancer cells was determined by atomic force microscopy. The modified microfluidic chip was utilized to separate soft cells, and the 3D Matrigel culture system was to maintain the softness of tumor cells.
    [Chinese Medical Journal]

    Full Article

    RPL27 Contributes to Colorectal Cancer Proliferation and Stemness via PLK1 Signaling

    Human colorectal cancer cell lines HCT116 and HT29 were transfected with RPL27‑specific small interfering RNA and proliferation was assessed in vitro and in vivo using proliferation assays, fluorescence‑activated cell sorting and a xenograft mouse model.
    [International Journal Of Oncology]

    Abstract

    Human Endogenous Retrovirus K Contributes to a Stem Cell Niche in Glioblastoma

    Researchers reported pathological expression of HML-2 in malignant gliomas in both cerebrospinal fluid and tumor tissue that was associated with a cancer stem cell phenotype and poor outcomes.
    [European Journal Of Clinical Investigation]

    Full ArticlePress Release

    Cancer Stem Cell Activity of Copper(ii)-Terpyridine Complexes with Aryl Sulfonamide Group

    Scientists reported the synthesis, characterization, and anti-breast CSC properties of a series of copper(II)-terpyridine complexes containing aryl sulfonamide groups. All of the copper(II)-terpyridine complexes adopt distorted square pyramidal geometries and are suitably stable in biologically relevant solutions.
    [Dalton Transactions]

    Full ArticleGraphical Abstract

    GNPNAT1 Promotes the Stemness of Breast Cancer and Serves as a Potential Prognostic Biomarker

    Researchers evaluated the expression levels of GNPNAT1 in breast cancer (BC) and its effect on BC stem cells. The Cancer Genome Atlas database was used for the analysis of the expression of GNPNAT1 and its clinical significance.
    [Oncology Reports]

    Abstract

    Parathyroid Hormone-Related Protein Promotes the Proliferation of Patient-Derived Glioblastoma Stem Cells via Activating cAMP/PKA Signaling Pathway

    Using the Cancer Genome Atlas database, investigators found higher expression of PTHrP in GBM, which correlated inversely with survival. Glioblastoma stem cells were established from three human glioblastoma samples obtained after surgical resection.
    [International Journal Of Stem Cells]

    Abstract

    Effects of a Differentiating Therapy on Cancer-Stem-Cell-Driven Tumors

    To describe the effects of a differentiating agent that reprograms CSCs into differentiated cancer cells (DCC), researchers adapted a differential equation model developed to investigate tumorspheres, which were assumed to consist of jointly evolving CSC and DCC populations
    [Journal Of Theoretical Biology]

    Full Article
    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    REVIEWS

    Measuring and Modeling Tumor Heterogeneity Across Scales

    Investigators classify regulators of cancer into three categories based on scale: tumor-cell-intrinsic, tissue-microenvironment, and organism-level sources.
    [Nature Reviews Bioengineering]

    Abstract

    Histone Modifications in Drug-Resistant Cancers: From a Cancer Stem Cell and Immune Evasion Perspective

    Scientists summarize recent findings regarding the role of histone modifiers in the development of drug-resistant cancer cells from the perspectives of CSCs and immune evasion.
    [Experimental & Molecular Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    CANbridge to Continue CAN008 Phase II Trial in Glioblastoma Multiforme (GBM) in China Based on Interim Analysis of Independent Data Monitoring Committee

    CANbridge Pharmaceuticals, Inc. announced that, based on the interim analysis recommendation of the independent data monitoring committee, it plans to continue the ongoing Phase II study of CAN008 in patients with newly diagnosed glioblastoma multiforme in China to completion.
    [CANbridge Pharmaceuticals, Inc.]

    Press Release

    OSE Immunotherapeutics Announces New US Patent Granted for the Use of Tedopi® in Cancer Patients after Failure with PD-1/PD-L1 Immune Checkpoint Inhibitor Treatment

    OSE Immunotherapeutics SA announced that the United States Patent and Trademark Office has granted a new patent protecting Tedopi®, a therapeutic cancer vaccine treating HLA-A2 positive patients after secondary resistance to PD-1/PD-L1 immune checkpoint inhibitor treatment.
    [OSE Immunotherapeutics]

    Press Release
    FEATURED EVENT

    2023 Hormone-Dependent Cancers Conference GRC

    August 6 – 11, 2023
    Newry, Maine, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Cancer Research

    Umeå University – Umeå, Sweden

    Postdoctoral Fellow – Tumor Microenvironment

    Francis Crick Institute – London, England, United Kingdom

    Postdoctoral Scientist – Cancer Immunotherapy

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    Postdoctoral Fellowship – Tumor Metastasis

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Professor – Hematology & Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    > See All Jobs

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