Cancer Stem Cell News Volume 12.27 | Jul 12 2023

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    2023-07-12 | CSCN 12.27


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.27 – 12 July, 2023
    TOP STORY

    Combined Proteomics and CRISPR‒Cas9 Screens in PDX Identify ADAM10 As Essential for Leukemia In Vivo

    Investigators attempted to identify responsible surface proteins, and performed deep proteome profiling on minute numbers of dormant patient-derived xenograft leukemia stem cells isolated from mice.
    [Molecular Cancer]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Leukemic Progenitor Compartment Serves as a Prognostic Measure of Cancer Stemness in Patients with Acute Myeloid Leukemia

    Researchers confirmed that the presence of leukemic stem cells detected through in vivo xenograft transplantation was associated with poor survival.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Understanding and Overcoming Immunosuppression Shaped by Cancer Stem Cells

    The authors discuss the current understanding of CSC-mediated immune evasion and provides a prospective view on how researchers can better understand and overcome the intrinsic immune privilege of CSCs and the extrinsic immune-suppressive microenvironment shaped by them.
    [Cancer Research]

    Full Article

    Co-Targeting Autophagy and NRF2 Signaling Triggers Mitochondrial Superoxide to Sensitize Oral Cancer Stem Cells for Cisplatin-Induced Apoptosis

    Scientists demonstrated that cisplatin treatment enriches the CSCs population by increasing autophagosome formation and speeding up autophagosome-lysosome fusion by recruiting RAB7 to autolysosomes.
    [Free Radical Biology And Medicine]

    Full Article

    Sequentially Degradable Hydrogel-Microsphere Loaded with Doxorubicin and Pioglitazone Synergistically Inhibits Cancer Stemness of Osteosarcoma

    Researchers reported a treatment strategy for osteosarcoma using hydrogel−microspheres complex mainly composed of collagenase and PLGA microspheres carrying Pioglitazone and Doxorubicin.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Targeting ITGB4/SOX2-Driven Lung Cancer Stem Cells Using Proteasome Inhibitors

    CSCs isolated from lung squamous cell carcinoma patients were found to be resistant to cisplatin but knocking down ITGB4 or SOX2 sensitized them to cisplatin. Carfilzomib synergized with cisplatin and suppressed CSC growth by inhibiting ITGB4 and SOX2 expression.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Cancer Stem Cells Promote Lymph Nodes Metastasis of Breast Cancer by Reprogramming Tumor Microenvironment

    The authors unraveled how CSCs reprogramed the tumor immune microenvironment (TIME) to facilitate lymph node metastasis. Utilizing single-cell RNA sequencing, they profiled TIME in primary cancer and corresponding metastatic lymph node samples from patients at their institution.
    [Translational Oncology]

    Full Article

    Cross Talk Between Tumor Stemness and Microenvironment for Prognosis and Immunotherapy of Uveal Melanoma

    Scientists observed that mDNAsi was significantly linked with overall survival (OS) time of uveal melanoma (UVM), but no association was discovered between mRNAsi and OS. Stratification analysis indicated that the prognostic value of mDNAsi was only limited in subtype D of UVM.
    [Journal Of Cancer Research And Clinical Oncology]

    Abstract

    Isoliensinine Augments the Therapeutic Potential of Paclitaxel in Multidrug-Resistant Colon Cancer Stem Cells and Induced Mitochondria-Mediated Cell Death

    Researchers evaluated the chemo-sensitizing potential of the combinatorial regimen of isoliensinine (ISO) and Paclitaxcel on multidrug-resistant-HCT-15 cells to reduce the dose requirement of both ISO and Paclitaxcel.
    [Journal Of Biochemical And Molecular Toxicology]

    Abstract
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    REVIEWS

    Crosstalk Between Autophagy and CSCs: Molecular Mechanisms and Translational Implications

    It has been found that autophagy can contribute to the maintenance of CSC stemness, facilitate the tumor cells adapt to changes in the microenvironment, and promote tumor survival, whereas in some other cases autophagy acts as an important process involved in the deprivation of CSC stemness.
    [Cell Death & Disease]

    Full Article
    INDUSTRY AND POLICY NEWS

    FDA Removes Partial Clinical Hold on TakeAim Leukemia Trial of Emavusertib

    The FDA has lifted a partial clinical hold on the Phase I/II TakeAim Leukemia trial of emavusertib as monotherapy and in combination with azacytidine and venetoclax for the treatment of patients with relapsed/refractory acute myeloid leukemia or high-risk myelodysplastic syndrome.
    [Targeted Oncology]

    Press Release

    Kazia’s Paxalisib Receives Fast Track Designation from FDA for Treatment of Solid Tumor Brain Metastases Harboring PI3K Pathway Mutations in Combination with Radiation Therapy

    Kazia Therapeutics Limited announced that its lead program, paxalisib, has been awarded Fast Track Designation by the FDA for the treatment of solid tumor brain metastases harboring PI3K pathway mutations in combination with radiation therapy.
    [Kazia Therapeutics Limited]

    Press Release
    FEATURED EVENT

    São Paulo International Symposium

    September 22 – 24, 2023
    Ribeirao Preto, Brazil

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Scientist – Tumor Immunology and Radio-Immunotherapy

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    Postdoctoral Position – Immune Modulation in Cancer and Microbiome

    The Hospital of the University of Munich – Munich, Germany

    Postdoctoral Fellow – Pancreatic & Gastrointestinal Cancer

    Rutgers Cancer Institute of New Jersey – New Brunswick, New Jersey, United States

    Postdoctoral Fellow – Tumor Microenvironment

    The University of Texas MD Anderson Cancer Center- Houston, Texas, United States

    Postdoctoral Research Scholar – Regulation of Tumor and Ocular Angiogenesis

    University of California, San Diego – La Jolla, California, United States

    > See All Jobs

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