| Vol. 12.27 – 12 July, 2023 |
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| Investigators attempted to identify responsible surface proteins, and performed deep proteome profiling on minute numbers of dormant patient-derived xenograft leukemia stem cells isolated from mice. [Molecular Cancer] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers confirmed that the presence of leukemic stem cells detected through in vivo xenograft transplantation was associated with poor survival. [Cell Reports Medicine] |
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| The authors discuss the current understanding of CSC-mediated immune evasion and provides a prospective view on how researchers can better understand and overcome the intrinsic immune privilege of CSCs and the extrinsic immune-suppressive microenvironment shaped by them. [Cancer Research] |
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| Scientists demonstrated that cisplatin treatment enriches the CSCs population by increasing autophagosome formation and speeding up autophagosome-lysosome fusion by recruiting RAB7 to autolysosomes. [Free Radical Biology And Medicine] |
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| Researchers reported a treatment strategy for osteosarcoma using hydrogel−microspheres complex mainly composed of collagenase and PLGA microspheres carrying Pioglitazone and Doxorubicin. [Biomedicine & Pharmacotherapy] |
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| CSCs isolated from lung squamous cell carcinoma patients were found to be resistant to cisplatin but knocking down ITGB4 or SOX2 sensitized them to cisplatin. Carfilzomib synergized with cisplatin and suppressed CSC growth by inhibiting ITGB4 and SOX2 expression. [iScience] |
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| The authors unraveled how CSCs reprogramed the tumor immune microenvironment (TIME) to facilitate lymph node metastasis. Utilizing single-cell RNA sequencing, they profiled TIME in primary cancer and corresponding metastatic lymph node samples from patients at their institution. [Translational Oncology] |
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| Scientists observed that mDNAsi was significantly linked with overall survival (OS) time of uveal melanoma (UVM), but no association was discovered between mRNAsi and OS. Stratification analysis indicated that the prognostic value of mDNAsi was only limited in subtype D of UVM. [Journal Of Cancer Research And Clinical Oncology] |
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| Researchers evaluated the chemo-sensitizing potential of the combinatorial regimen of isoliensinine (ISO) and Paclitaxcel on multidrug-resistant-HCT-15 cells to reduce the dose requirement of both ISO and Paclitaxcel. [Journal Of Biochemical And Molecular Toxicology] |
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| It has been found that autophagy can contribute to the maintenance of CSC stemness, facilitate the tumor cells adapt to changes in the microenvironment, and promote tumor survival, whereas in some other cases autophagy acts as an important process involved in the deprivation of CSC stemness. [Cell Death & Disease] |
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| The FDA has lifted a partial clinical hold on the Phase I/II TakeAim Leukemia trial of emavusertib as monotherapy and in combination with azacytidine and venetoclax for the treatment of patients with relapsed/refractory acute myeloid leukemia or high-risk myelodysplastic syndrome. [Targeted Oncology] |
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| Kazia Therapeutics Limited announced that its lead program, paxalisib, has been awarded Fast Track Designation by the FDA for the treatment of solid tumor brain metastases harboring PI3K pathway mutations in combination with radiation therapy. [Kazia Therapeutics Limited] |
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| September 22 – 24, 2023 Ribeirao Preto, Brazil |
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| University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| The Hospital of the University of Munich – Munich, Germany |
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| Rutgers Cancer Institute of New Jersey – New Brunswick, New Jersey, United States |
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| The University of Texas MD Anderson Cancer Center- Houston, Texas, United States |
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| University of California, San Diego – La Jolla, California, United States |
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