Cancer Stem Cell News Volume 12.28 | Jul 19 2023

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    2023-07-18 | CSCN 12.28


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.28 – 19 July, 2023
    TOP STORY

    Cancer Cell Employs a Microenvironmental Neural Signal Trans-Activating Nucleus-Mitochondria Coordination to Acquire Stemness

    A pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types revealed that cAMP-responsive element transcription factors were convergent activators for cancer stemness.
    [Signal Transduction And Targeted Therapy]

    Full Article
    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    PUBLICATIONSRanked by the impact factor of the journal

    Activation of GPR44 Decreases Severity of Myeloid Leukemia via Specific Targeting of Leukemia Initiating Stem Cells

    Using a murine acute myeloid leukemia (AML) model, human AML cell lines, and patient samples, scientists showed that AML leukemia-initiating stem cells were sensitive to endogenous and exogenous cyclopentenone prostaglandin-J, Δ12-PGJ2, and 15d-PGJ2.
    [Cell Reports]

    Full ArticleGraphical Abstract

    IL-1RA Promotes Oral Squamous Cell Carcinoma Malignancy Through Mitochondrial Metabolism-Mediated EGFR/JNK/SOX2 Pathway

    Tumor tissues from oral squamous cell carcinoma patients were assessed for protein expression by immunohistochemistry. Patient survival was evaluated by Kaplan–Meier curve analysis.
    [Journal Of Translational Medicine]

    Full Article

    Rab11-FIP4 Interacts with ARF5 to Promote Cancer Stemness in Hepatocellular Carcinoma

    Scientists found that Rab11-family interacting protein 4 (FIP4) was dramatically increased in HCC cell lines and tissues, and had a positive correlation with cancer stemness.
    [Journal Of Physiology And Biochemistry]

    Abstract

    Cancer Associated Fibroblasts Promote Cancer Stemness by Inducing Expression of the Chromatin Modifying Protein CBX4 in Squamous Cell Carcinoma

    Investigators showed CBX4 was a critical regulator of the CSC phenotype in squamous cell carcinomas of the skin and hypopharynx. Moreover, Cancer associated fibroblasts could promote the expression of CBX4 in the CSC population through secretion of IL-6.
    [Carcinogenesis]

    Abstract
    Graphical Abstract

    Activin and Hepatocyte Growth Factor Promotes Colorectal Cancer Stemness and Metastasis through FOXM1/SOX2/CXCR4 Signaling

    The authors sequentially treated colorectal cancer cells with activin and hepatocyte growth factor and examined CSC marker expression, self-renewal, tumorigenesis, and metastasis.
    [Gut and Liver]

    Full Article

    Stem Cell Properties of Gastric Cancer Stem-Like Cells Under Stress Conditions Are Regulated via the C-fos/UCH-L3/β-Catenin Axis

    In response to glucose starvation, the levels of β-catenin and stemness-related genes were upregulated in gastric CSCs (gCSCs), while the levels of β-catenin declined in GCICs.
    [Molecules And Cells]

    Abstract

    Dipeptidase-2 Is a Prognostic Marker in Lung Adenocarcinoma That Is Correlated with Its Sensitivity to Cisplatin

    Gene expression profiles were extracted from the Gene Expression Omnibus database and mRNA expression data were downloaded from The Cancer Genome Atlas database. In addition, TIMER 2.0 database was used to analyze the expression of genes in normal and multiple tumor tissues.
    [Oncology Reports]

    Abstract

    NIK-Mediated Reactivation of SIX2 Enhanced the CSC-Like Traits of Hepatocellular Carcinoma Cells Through Suppressing Ubiquitin–Proteasome System

    Researchers found that NF-κB Inducing Kinase (NIK) level was upregulated in hepatocellular carcinoma tissues compared to that of normal tissues, and positively correlated with the levels of CSC markers.
    [Environmental Toxicology]

    Abstract
    Stay up-to-date with the latest stem cell research by listening to the Stem Cell Podcast!
    REVIEWS

    Targeting Cancer Stem Cells as a Strategy for Reducing Chemotherapy Resistance in Head and Neck Cancers

    Head and neck cancer cells belonging to the stem cell population are distinguished by the high expression of certain surface proteins, pluripotency-related transcription factors, and increased activity of aldehyde dehydrogenase. Chemotherapy itself increases the percentage of stem-like cells.
    [Journal Of Cancer Research And Clinical Oncology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Aspartame Is a Possible Carcinogen: The Science Behind the Decision

    The cancer-research arm of the World Health Organization has classified the low-calorie sweetener aspartame as ‘possibly carcinogenic’. The International Agency for Research on Cancer in Lyon, France, said its decision, announced on 14 July, was based on limited evidence for liver cancer in studies on people and rodents.
    [Nature]

    Press Release

    Ivy Brain Tumor Center Opens Novel Clinical Trial to Test Direct-to-Tumor Drug Delivery Method

    In an effort to discover new treatments for brain tumors, such as glioblastoma, the Ivy Brain Tumor Center at Barrow Neurological Institute, announced the initiation of a ground-breaking Phase 0 clinical trial that tests a new experimental drug delivery method called superselective intra-arterial infusion, or SSIAI.
    [Ivy Brain Tumor Center]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Pancreatic Cancer

    September 27 – 30, 2023
    Boston, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Pancreatic Cancer & Iron Metabolism

    Aarhus University – Aarhus, Denmark

    Postdoctoral Fellow – Skin Development, Homeostasis, and Melanoma Initiation

    Duke University – Durham, North Carolina, United States

    Postdoctoral Fellow – Cancer Biology

    City of Hope – Duarte, California, United States

    Postdoctoral Scientist – Tumor Immunology and Radio-Immunotherapy

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    Postdoctoral Position – Immune Modulation in Cancer and Microbiome

    The Hospital of the University of Munich – Munich, Germany

    > See All Jobs

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