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Vol. 12.29 – 26 July, 2023
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Scientists demonstrated that expression of KRAS(G12D) in differentiated alveolar epithelial type I (AT1) cells reprogrammed them slowly and asynchronously back into AT2 stem cells that go on to generate indolent tumors.
[Nature]
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PUBLICATIONSRanked by the impact factor of the journal
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Experimental results indicated that glucosamine-labeled liposomal ceramide could be efficiently transported between cancer cells by GLUT1 transporters and substantially accumulated in the hypoxic area in in vitro CSC spheroids and in vivo tumor xenografts.
[ACS Nano]
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Researchers discovered the expression profile and functional roles of circRNAs in gastric CSCs (GCSCs). A spheroid formation assay was conducted to enrich GCSCs. Genome-wide sequencing of circRNAs showed that a novel circRNA, circSLC4A7, was one of the most upregulated circRNAs in GCSCs.
[Cell Death & Disease]
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Four brain metastasis stem cell lines from patients with colorectal cancer were obtained by mechanical dissociation of patient’s tumors and selection of CSCs by appropriate culture conditions.
[Cellular And Molecular Gastroenterology And Hepatology]
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To target the cell surface glucose-regulated protein 78 (GRP78), CAR-T cells based on its binding peptide were generated. In vitro two glioblastoma cell lines and glioma stem cells were used to confirm the localization of cell surface GRP78 and the cytotoxicity of the CAR-T cells.
[Journal Of Translational Medicine]
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Gastric cancer stemness influenced by B7-H3 was detected both in vitro and in vivo. The expression of stemness-related markers was examined by reverse transcriptase quantitative polymerase chain reaction, Western blotting, and flow cytometry.
[Chinese Medical Journal]
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The authors used propofol to treat LOVO and SW480 cells and Cell Counting Kit-8 to detect proliferation. Self-renewal capacity, cell invasion and migration, flow cytometry analysis, qPCR and Western blotting were performed to detect the suppression of propofol to colon cancer cells and the underlying mechanism.
[Discover Oncology]
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Scientists analyzed how KRAS activation in gastric CSCs promoted tumor angiogenesis and metastasis. Gastric cancer CSCs were found to secrete pro-angiogenic factors such as vascular endothelial growth factor A, and inhibition of KRAS markedly reduced secretion of these factors.
[BMC Cancer]
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CD44+/CD133+ human ovarian cancer stem cells (OCSCs) were isolated from human ovarian cancer tissues. OCSCs were interfered with using anisomycin and specific small-interfering RNA.
[Journal Of Gene Medicine]
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Investigators summarize and briefly present the key pathways of ferroptosis, paying special attention to the regulation of ferroptosis as well as its dual role as an oncogenic and as a tumor suppressor event in various human cancers.
[Cell Death & Disease]
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Gilead Sciences, Inc. announced that the Phase III ENHANCE study in higher-risk myelodysplastic syndromes has been discontinued due to futility based on a planned analysis.
[Gilead Sciences, Inc. (BusinessWire, Inc.)]
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Ambrx Biopharma Inc. announced that the US FDA has granted Fast Track designation to Ambrx’s proprietary anti-PSMA antibody-drug conjugate investigational therapy, ARX517, for the treatment of patients with metastatic castration-resistant prostate cancer.
[Ambrx Biopharma Inc.]
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October 4 – 6, 2023
Paris, France
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City of Hope – Duarte, California, United States
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Albert Einstein College of Medicine – New York City, New York, United States
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Centre for Oncology and Immunology – Hong Kong, Hong Kong
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University of Texas Health – San Antonio, Texas, United States
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Institut Pasteur – Paris, France
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
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Neural Cell News
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Pancreatic Cell News
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Pulmonary Cell News
Umbilical & Placental Cell News