Cancer Stem Cell News Volume 12.30 | August 02 2023


    2023-08-02 | CSCN 12.30

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.30 – 2 August, 2023

    Cancer Cell Employs a Microenvironmental Neural Signal Trans-Activating Nucleus-Mitochondria Coordination to Acquire Stemness

    A pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types revealed that cAMP-responsive element transcription factors were convergent activators for cancer stemness.
    [Signal Transduction and Targeted Therapy]

    Full Article
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    Cancer Cell-Mitochondria Hybrid Membrane Coated Gboxin Loaded Nanomedicines for Glioblastoma Treatment

    The authors presented a biomimetic nanomedicine by coating cancer cell-mitochondria hybrid membrane on the surface of Gboxin-loaded nanoparticles. An additional design element used a reactive oxygen species responsive polymer to facilitate at-site Gboxin release.
    [Nature Communications]

    Full Article

    ISG15 and ISGylation Modulates Cancer Stem Cell-Like Characteristics in Promoting Tumor Growth of Anaplastic Thyroid Carcinoma

    The correlation between interferon-stimulated gene 15 (ISG15) expression and tumor stem cells and malignant progression of anaplastic thyroid carcinoma was analyzed by single-cell RNA sequence from the Gene Expression Omnibus.
    [Journal of Experimental & Clinical Cancer Research]

    Full ArticleGraphical Abstract

    Coexisting Cancer Stem Cells with Heterogeneous Gene Amplifications, Transcriptional Profiles, and Malignancy Are Isolated from Single Glioblastomas

    Investigators described the systematic derivation, propagation, and characterization of multiple distinct glioblastoma stem cells from single, treatment-naive glioblastoma.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Arginine Dependency Is a Therapeutically Exploitable Vulnerability in Chronic Myeloid Leukemic Stem Cells

    Researchers performed an amino acid drop-out screen and applied pre-clinical models of chronic phase chronic myeloid leukemia (CML) to identify arginine as a nutrient essential for primary human CML cells.
    [EMBO Reports]

    Full ArticleGraphical Abstract

    Multi-Omic Integration of DNA Methylation and Gene Expression Data Reveals Molecular Vulnerabilities in Glioblastoma

    Scientists exploited the benefits of genome-wide multi-omic approaches to identify potential molecular vulnerabilities existing in patients with glioblatoma.
    [Molecular Oncology]

    Full Article

    SPOPL Induces Tumorigenicity and Stemness in Glioma Stem Cells by Activating Notch Signaling

    Investigators explored the effect of SPOPL on the proliferation, self-renewal, and differentiation ability of glioma stem cells in vivo and in vitro.
    [Journal of Neuro-Oncology]


    Cancer Stem Cells Persist Despite Cellular Damage, Emergence of the Refractory Cell Population

    Using human colorectal cancer organoids prepared from surgical specimens, the authors looked at changes in CSCs identified by single-cell analysis.
    [Annals of Surgical Oncology]

    Full Article

    Fumagillin Regulates Stemness and Malignancies in Cancer Stem-Like Cells Derived from Liver Cancer via Targeting to MetAP-2

    Researchers measured the effects of fumagillin on malignant cell characteristics and mitochondrial function and assessed its regulatory role on methionine aminopeptidase-2 (MetAP-2).
    [PLOS One]

    Full Article
    Keep current with the latest in neural cell research.

    Cancer Quiescence: Non-Coding RNAs in the Spotlight

    When stress conditions are restrained, and tumor microenvironment becomes beneficial, quiescent cancer cells re-enter cell cycle to facilitate tumor spread and cancer progression/metastasis. Recent studies have highlighted the dynamic role of regulatory non-coding RNAs in orchestrating cancer quiescence.
    [Trends In Molecular Medicine]


    Senate Panel Approves 2% Bump for NIH Budget in 2024

    Although below the rate of biomedical inflation, it is far more generous than a corresponding House of Representatives bill that would slash NIH’s budget by 6%.
    [Science Insider]

    Press Release

    Great Debates & Updates | Gastrointestinal Malignacies

    September 28 – 30, 2023
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    Physician-Scientist Faculty Position – Medicine

    Baylor College of Medicine – Houston, Texas, United States

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    IRB Barcelona – Barcelona, Spain

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    University of Cincinnati – Cincinnati, Ohio, United States

    Postdoctoral Positions – Cancer Drug Persistence & Tumor Microenvironment

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