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Vol. 12.30 – 2 August, 2023
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A pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types revealed that cAMP-responsive element transcription factors were convergent activators for cancer stemness.
[Signal Transduction and Targeted Therapy]
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PUBLICATIONSRanked by the impact factor of the journal
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The authors presented a biomimetic nanomedicine by coating cancer cell-mitochondria hybrid membrane on the surface of Gboxin-loaded nanoparticles. An additional design element used a reactive oxygen species responsive polymer to facilitate at-site Gboxin release.
[Nature Communications]
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The correlation between interferon-stimulated gene 15 (ISG15) expression and tumor stem cells and malignant progression of anaplastic thyroid carcinoma was analyzed by single-cell RNA sequence from the Gene Expression Omnibus.
[Journal of Experimental & Clinical Cancer Research]
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Investigators described the systematic derivation, propagation, and characterization of multiple distinct glioblastoma stem cells from single, treatment-naive glioblastoma.
[Cell Reports]
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Researchers performed an amino acid drop-out screen and applied pre-clinical models of chronic phase chronic myeloid leukemia (CML) to identify arginine as a nutrient essential for primary human CML cells.
[EMBO Reports]
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Scientists exploited the benefits of genome-wide multi-omic approaches to identify potential molecular vulnerabilities existing in patients with glioblatoma.
[Molecular Oncology]
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Investigators explored the effect of SPOPL on the proliferation, self-renewal, and differentiation ability of glioma stem cells in vivo and in vitro.
[Journal of Neuro-Oncology]
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Using human colorectal cancer organoids prepared from surgical specimens, the authors looked at changes in CSCs identified by single-cell analysis.
[Annals of Surgical Oncology]
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Researchers measured the effects of fumagillin on malignant cell characteristics and mitochondrial function and assessed its regulatory role on methionine aminopeptidase-2 (MetAP-2).
[PLOS One]
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When stress conditions are restrained, and tumor microenvironment becomes beneficial, quiescent cancer cells re-enter cell cycle to facilitate tumor spread and cancer progression/metastasis. Recent studies have highlighted the dynamic role of regulatory non-coding RNAs in orchestrating cancer quiescence.
[Trends In Molecular Medicine]
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Although below the rate of biomedical inflation, it is far more generous than a corresponding House of Representatives bill that would slash NIH’s budget by 6%.
[Science Insider]
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September 28 – 30, 2023
New York, New York, United States
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Baylor College of Medicine – Houston, Texas, United States
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IRB Barcelona – Barcelona, Spain
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University of Cincinnati – Cincinnati, Ohio, United States
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Albert Einstein College of Medicine – New York City, New York, United States
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NCI Center for Cancer Research – Bethesda, Maryland, United States
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