 | | Vol. 12.31 – 9 August, 2023 |
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| Scientists showed that Tet2 deficiency significantly facilitated leukemogenesis in various acute myeloid leukemia models through promoting homing of leukemia stem cells into bone marrow niche to increase their self-renewal/proliferation.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified a lncRNA DARS1-AS1–controlled posttranscriptional circuitry that promoted the malignant properties of glioblastoma cells/glioma stem cells.
[Science Advances] |
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| Investigators identified cold sensitivity at 4°C, commonly used for sample storage, as a novel vulnerability that selectively killed acute myeloid leukemic stem cells with active fatty acid oxidation-supported mitochondrial oxidative phosphorylation while sparing normal hematopoietic stem cells.
[Cancer Research] |
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| Scientists examined the effect of a CDK7 inhibitor, THZ1, and multiple CDK9 inhibitors on glioblastoma cell lines, patient-derived temozolomide-resistant and responsive primary tumor cells and glioma stem cells.
[Neuro-Oncology] |
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| The authors investigated the in vitro and in vivo implications of Δ40p53 expression in breast cancer. We have shown that genes associated with cell differentiation are downregulated while those associated with stem cell regulation are upregulated in invasive ductal carcinomas expressing high levels of Δ40p53.
[Cell Death & Disease] |
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| Researchers demonstrated that undifferentiated cells are more sensitive to ferroptosis than differentiated cells, and cystine transporter SLC7A11 protein is highly up-regulated by deubiquitinase DUBA in differentiated cells.
[Oncogene] |
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| Parental and JQ1-resistant SUM149 and SUM159 exhibited a stem cell-like and embryonic diapause (SCLED) cell state as well as a transitional cell state between the SCLED state that is present in both treatment naïve and JQ1 treated cells, and a number of JQ1 resistant cell states.
[Cell Death Discovery] |
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| CCK-8, colony, and tumorsphere formation assay were used to evaluate cancer cell viability and stemness, respectively. Western blotting was used to detect the protein expression. Tumor xenograft experiments were employed to examine the tumorigenicity of colorectal cancer cells in nude mice.
[Environmental Toxicology] |
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| Researchers attempted to develop a new cisplatin loaded hydroxyl functionalized single-walled carbon nanotube nanocarrier system to selectively eliminate gastric cancer stem cells.
[Heliyon] |
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| Scientists review the intrinsic and extrinsic mechanisms driving cell plasticity that promote tumor growth and proliferation as well as metastasis and drug tolerance.
[Nature Cancer] |
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| For what would have been Henrietta Lacks’ 103th birthday, her family got her some justice: A settlement with Thermo Fisher Scientific over the Massachusetts-based company’s use of cells obtained without her consent seven decades ago.
[STAT News] |
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| The FDA has granted orphan drug designation to LSTA1 for use as a potential therapeutic option in patients with malignant glioma, according to an announcement from Lisata Therapeutics, Inc.
[Lisata Therapeutics, Inc.] |
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| December 6 – 8, 2023
Geneva, Switzerland |
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| | National Institute of Health – Bethesda, Maryland, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Debiopharm – Lausanne, Switzerland |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | IRB Barcelona – Barcelona, Spain |
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