Cancer Stem Cell News Volume 12.31 | Aug 9 2023

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    2023-08-09 | CSCN 12.31


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.31 – 9 August, 2023
    TOP STORY

    TET2-Mediated mRNA Demethylation Regulates Leukemia Stem Cell Homing and Self-Renewal

    Scientists showed that Tet2 deficiency significantly facilitated leukemogenesis in various acute myeloid leukemia models through promoting homing of leukemia stem cells into bone marrow niche to increase their self-renewal/proliferation.
    [Cell Stem Cell]

    AbstractGraphical Abstract
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    PUBLICATIONSRanked by the impact factor of the journal

    Multiomics Analyses Reveal DARS1-AS1/YBX1–Controlled Posttranscriptional Circuits Promoting Glioblastoma Tumorigenesis/Radioresistance

    The authors identified a lncRNA DARS1-AS1–controlled posttranscriptional circuitry that promoted the malignant properties of glioblastoma cells/glioma stem cells.
    [Science Advances]

    Full Article

    Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold

    Investigators identified cold sensitivity at 4°C, commonly used for sample storage, as a novel vulnerability that selectively killed acute myeloid leukemic stem cells with active fatty acid oxidation-supported mitochondrial oxidative phosphorylation while sparing normal hematopoietic stem cells.
    [Cancer Research]

    Abstract

    CDK7 and CDK9 Inhibition Interferes with Transcription, Translation and Stemness, and Induces Cytotoxicity in GBM Irrespective of Temozolomide Sensitivity

    Scientists examined the effect of a CDK7 inhibitor, THZ1, and multiple CDK9 inhibitors on glioblastoma cell lines, patient-derived temozolomide-resistant and responsive primary tumor cells and glioma stem cells.
    [Neuro-Oncology]

    Abstract

    p53 Isoform Expression Promotes a Stemness Phenotype and Inhibits Doxorubicin Sensitivity in Breast Cancer

    The authors investigated the in vitro and in vivo implications of Δ40p53 expression in breast cancer. We have shown that genes associated with cell differentiation are downregulated while those associated with stem cell regulation are upregulated in invasive ductal carcinomas expressing high levels of Δ40p53.
    [Cell Death & Disease]

    Full Article

    The DUBA-SLC7A11-C-Myc Axis Is Critical for Stemness and Ferroptosis

    Researchers demonstrated that undifferentiated cells are more sensitive to ferroptosis than differentiated cells, and cystine transporter SLC7A11 protein is highly up-regulated by deubiquitinase DUBA in differentiated cells.
    [Oncogene]

    Abstract

    Single-Cell Trajectory Analysis Reveals a CD9 Positive State to Contribute to Exit from Stem Cell-Like and Embryonic Diapause States and Transit to Drug-Resistant States

    Parental and JQ1-resistant SUM149 and SUM159 exhibited a stem cell-like and embryonic diapause (SCLED) cell state as well as a transitional cell state between the SCLED state that is present in both treatment naïve and JQ1 treated cells, and a number of JQ1 resistant cell states.
    [Cell Death Discovery]

    Full Article

    Proanthocyanidins Inhibited Colorectal Cancer Stem Cell Characteristics through Wnt/β-Catenin Signaling

    CCK-8, colony, and tumorsphere formation assay were used to evaluate cancer cell viability and stemness, respectively. Western blotting was used to detect the protein expression. Tumor xenograft experiments were employed to examine the tumorigenicity of colorectal cancer cells in nude mice.
    [Environmental Toxicology]

    Abstract

    Formulation and Characterization of Cisplatin-Loaded Hydroxyl Functionalized Single-Walled Carbon Nanotubes for Targeting Gastric Cancer Stem Cells

    Researchers attempted to develop a new cisplatin loaded hydroxyl functionalized single-walled carbon nanotube nanocarrier system to selectively eliminate gastric cancer stem cells.
    [Heliyon]

    Full ArticleGraphical Abstract
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    REVIEWS

    Cancer Cell Plasticity During Tumor Progression, Metastasis and Response to Therapy

    Scientists review the intrinsic and extrinsic mechanisms driving cell plasticity that promote tumor growth and proliferation as well as metastasis and drug tolerance.
    [Nature Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    Henrietta Lacks Settlement Hailed by Experts As Step Toward Correcting Medicine’s Racist History

    For what would have been Henrietta Lacks’ 103th birthday, her family got her some justice: A settlement with Thermo Fisher Scientific over the Massachusetts-based company’s use of cells obtained without her consent seven decades ago.
    [STAT News]

    Press Release

    Lisata Therapeutics Announces US FDA Orphan Drug Designation Granted to LSTA1 for the Treatment of Malignant Glioma

    The FDA has granted orphan drug designation to LSTA1 for use as a potential therapeutic option in patients with malignant glioma, according to an announcement from Lisata Therapeutics, Inc.
    [Lisata Therapeutics, Inc.]

    Press Release
    FEATURED EVENT

    ESMO Immuno-Oncology Congress 2023

    December 6 – 8, 2023
    Geneva, Switzerland

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Pancreatic Cancer Research

    National Institute of Health – Bethesda, Maryland, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Senior Clinical Scientist – Oncology

    Debiopharm – Lausanne, Switzerland

    Physician-Scientist Faculty Position – Medicine

    Baylor College of Medicine – Houston, Texas, United States

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    IRB Barcelona – Barcelona, Spain

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