Cancer Stem Cell News Volume 12.32 | Aug 16 2023

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    2023-08-16 | CSCN 12.32


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.32 – 16 August, 2023
    TOP STORY

    CDK7-YAP-LDHD Axis Promotes D-Lactate Elimination and Ferroptosis Defense to Support Cancer Stem Cell-Like Properties

    Researchers discovered that cyclin-dependent kinase 7 (CDK7) phosphorylated nuclear Yes-associated protein 1 (YAP) at S127 and S397 sites and enhanced its transcription function, which promoted D-lactate dehydrogenase (LDHD) protein expression.
    [Signal Transduction And Targeted Therapy]

    Full Article
    PUBLICATIONSRanked by the impact factor of the journal

    NSUN2 Is a Glucose Sensor Suppressing cGAS/STING to Maintain Tumorigenesis and Immunotherapy Resistance

    Scientists reported that glucose was a cofactor binding to methyltransferase NSUN2 at amino acid 1–28 to promote NSUN2 oligomerization and activation.
    [Cell Metabolism]

    AbstractGraphical Abstract

    Photothermal-Triggered Sulfur Oxide Gas Therapy Augments Type I Photodynamic Therapy for Potentiating Cancer Stem Cell Ablation and Inhibiting Radioresistant Tumor Recurrence

    A near-infrared laser-induced synergistic therapeutic platform had been developed by incorporating aggregation-induced emission-active phototheranostic agents and sulfur dioxide prodrug into a biocompatible hydrogel to suppress malignant CSC growth.
    [Advanced Science]

    Full Article

    Ezh2 Promotes Mammary Tumor Initiation through Epigenetic Regulation of the Wnt and mTORC1 Signaling Pathways

    To gain a deeper understanding of the role of Enhancer of Zeste homology 2 (Ezh2) in the early stages of mammary tumor progression, investigators employed an inducible mammary organoid system bearing conditional Ezh2 alleles that faithfully recapitulated key events of luminal B breast cancer initiation.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    miR-30e-5p Regulates Leukemia Stem Cell Self-Renewal through the Cyb561/ROS Signaling Pathway

    Researchers presented compelling evidence that miR-30e-5p, a potential tumorsuppressive microRNA, exhibited significantly lower expression in acute myeloid leukemia samples compared to healthy bone marrow samples.
    [Haematologica]

    Abstract

    SETD1A Drives Stemness by Reprograming Epigenetic Landscape in Hepatocellular Carcinoma Stem Cells

    Applying a genome-scale CRISPR knockout screen, scientists identified that the H3K4 methyltransferase SETD1A and other members of Trithorax group proteins drove cancer stemness in hepatocellular carcinoma.
    [JCI Insight]

    AbstractFull ArticleGraphical Abstract

    Tspan15-ADAM10 Signaling Enhances Cancer Stem Cell-Like Properties and Induces Chemoresistance via Notch1 Activation in ICC

    Tspan15, ADAM10, and Notch1 expression and activation in fresh surgical specimens from 80 ICC patients and ICC cells were evaluated by immunohistochemistry, RT-PCR, western blotting, and flow cytometry.
    [Liver International]

    Abstract

    Estrogen-Related Receptor Alpha (ERRα) Promotes Cancer Stem Cell-Like Characteristics in Breast Cancer

    The authors have evaluated the role of ERRα in the maintenance of breast cancer stem cells using breast cancer cell lines.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Cancer Stem Cells Are Prevalent in the Basal-Like 2 and Mesenchymallike Triple-Negative Breast Cancer Subtypes In Vitro

    Breast cancer stem cell distribution was investigated using an integrated flow cytometry approach with the ALDEFLUOR assay and CD24/CD44 antibodies.
    [Frontiers in Cell and Developmental Biology]

    Abstract

    m6A-Modified circABCC4 Promotes Stemness and Metastasis of Prostate Cancer by Recruiting IGF2BP2 to Increase Stability of CCAR1

    Investigators found that circABCC4 was highly expressed in prostate cancer (PCa) tissues and cells, and elevated circABCC4 level indicated a poor overall survival of PCa patients.
    [Cancer Gene Therapy]

    Abstract

    Promoter Hypermethylation of Neural-Related Genes Is Compatible with Stemness in Solid Cancers

    To evaluate the presence of a neural-related DNA hypermethylation fingerprint in colon cancer and its relevance to carcinogenesis in general, the authors considered 16 solid cancer types available in The Cancer Genome Atlas.
    [Epigenetics & Chromatin]

    Full Article

    Biomimetic Microenvironmental Stiffness Boosts Stemness of Pancreatic Ductal Adenocarcinoma via Augmented Autophagy

    To understand the effect of the underlying interaction of matrix stiffness and stemness on pancreatic ductal adenocarcinoma, a methacrylated gelatin hydrogel with tunable stiffness was applied for incubating MIA PaCa-2 and PANC-1 cells.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract

    Cancer-Associated Fibroblasts Nurture LGR5 Marked Liver Tumor-Initiating Cells and Promote Their Tumor Formation, Growth, and Metastasis

    Both of the transgenic LGR5-diphtheria toxin receptor-GFP knock-in mice and transgenic Rosa26-mT mice developed primary liver tumors by diethylnitrosamine administration.
    [Cancer Medicine]

    Full Article
    Virtual Poster Presentation: CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly
    REVIEWS

    Cancer Stem Cells in Brain Tumors: From Origin to Clinical Implications

    The authors summarize the current knowledge of CSC markers and stemness regulators in brain tumors.
    [MedComm]

    Full Article
    INDUSTRY AND POLICY NEWS

    In Battle Against Pancreatic Cancer, Grant-Funded H-FIRE Study Offers Hope

    The National Institutes of Health has awarded $2.6 million to a Virginia Tech team over five years for a study of high frequency irreversible electroporation (H-FIRE) for tumor ablation and immune system activation in cases of pancreatic cancer.
    [Virginia Tech]

    Press Release

    SIU Prof Gets $445K Grant for Genetic Research on a Devastating Childhood Cancer

    A researcher at Southern Illinois University Carbondale will use a $445,500 federal grant to explore ways of turning off a genetic switch that allows rare but devasting cancer to progress in children.
    [Southern Illinois University Carbondale]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Ovarian Cancer

    October 5 – 7, 2023
    Boston, Massachusetts, United States

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    JOB OPPORTUNITIES

    Senior Scientific Officer – Initiation of Hepatocellular Carcinoma

    CRUK Beatson Institute – Glasgow, Scotland, United Kingdom

    Postdoctoral Associate – Prostate Cancer Metastasis

    Stony Brook University – Stony Brook, New York, United States

    Postdoctoral Fellow – Prostate Cancer Research

    Georgia Cancer Center at Augusta University – Augusta, Georgia, United States

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    Principal Investigators – Molecular Cell Science

    Center for Excellence in Molecular Cell Science – Shanghai, China

    > See All Jobs

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