| Vol. 12.32 – 16 August, 2023 |
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| Researchers discovered that cyclin-dependent kinase 7 (CDK7) phosphorylated nuclear Yes-associated protein 1 (YAP) at S127 and S397 sites and enhanced its transcription function, which promoted D-lactate dehydrogenase (LDHD) protein expression. [Signal Transduction And Targeted Therapy] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that glucose was a cofactor binding to methyltransferase NSUN2 at amino acid 1–28 to promote NSUN2 oligomerization and activation. [Cell Metabolism] |
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| A near-infrared laser-induced synergistic therapeutic platform had been developed by incorporating aggregation-induced emission-active phototheranostic agents and sulfur dioxide prodrug into a biocompatible hydrogel to suppress malignant CSC growth. [Advanced Science] |
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| To gain a deeper understanding of the role of Enhancer of Zeste homology 2 (Ezh2) in the early stages of mammary tumor progression, investigators employed an inducible mammary organoid system bearing conditional Ezh2 alleles that faithfully recapitulated key events of luminal B breast cancer initiation. [Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers presented compelling evidence that miR-30e-5p, a potential tumorsuppressive microRNA, exhibited significantly lower expression in acute myeloid leukemia samples compared to healthy bone marrow samples. [Haematologica] |
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| Applying a genome-scale CRISPR knockout screen, scientists identified that the H3K4 methyltransferase SETD1A and other members of Trithorax group proteins drove cancer stemness in hepatocellular carcinoma. [JCI Insight] |
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| Tspan15, ADAM10, and Notch1 expression and activation in fresh surgical specimens from 80 ICC patients and ICC cells were evaluated by immunohistochemistry, RT-PCR, western blotting, and flow cytometry. [Liver International] |
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| The authors have evaluated the role of ERRα in the maintenance of breast cancer stem cells using breast cancer cell lines. [Stem Cell Reviews and Reports] |
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| Breast cancer stem cell distribution was investigated using an integrated flow cytometry approach with the ALDEFLUORâ„¢ assay and CD24/CD44 antibodies. [Frontiers in Cell and Developmental Biology] |
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| Investigators found that circABCC4 was highly expressed in prostate cancer (PCa) tissues and cells, and elevated circABCC4 level indicated a poor overall survival of PCa patients. [Cancer Gene Therapy] |
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| To evaluate the presence of a neural-related DNA hypermethylation fingerprint in colon cancer and its relevance to carcinogenesis in general, the authors considered 16 solid cancer types available in The Cancer Genome Atlas. [Epigenetics & Chromatin] |
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| To understand the effect of the underlying interaction of matrix stiffness and stemness on pancreatic ductal adenocarcinoma, a methacrylated gelatin hydrogel with tunable stiffness was applied for incubating MIA PaCa-2 and PANC-1 cells. [ACS Biomaterials Science & Engineering] |
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| Both of the transgenic LGR5-diphtheria toxin receptor-GFP knock-in mice and transgenic Rosa26-mT mice developed primary liver tumors by diethylnitrosamine administration. [Cancer Medicine] |
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| The authors summarize the current knowledge of CSC markers and stemness regulators in brain tumors. [MedComm] |
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| The National Institutes of Health has awarded $2.6 million to a Virginia Tech team over five years for a study of high frequency irreversible electroporation (H-FIRE) for tumor ablation and immune system activation in cases of pancreatic cancer. [Virginia Tech] |
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| A researcher at Southern Illinois University Carbondale will use a $445,500 federal grant to explore ways of turning off a genetic switch that allows rare but devasting cancer to progress in children. [Southern Illinois University Carbondale] |
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| October 5 – 7, 2023 Boston, Massachusetts, United States |
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| CRUK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| Stony Brook University – Stony Brook, New York, United States |
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| Georgia Cancer Center at Augusta University – Augusta, Georgia, United States |
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| Creative Biolabs – New York, New York, United States |
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| Center for Excellence in Molecular Cell Science – Shanghai, China |
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