 | | Vol. 12.32 – 16 August, 2023 |
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| Researchers discovered that cyclin-dependent kinase 7 (CDK7) phosphorylated nuclear Yes-associated protein 1 (YAP) at S127 and S397 sites and enhanced its transcription function, which promoted D-lactate dehydrogenase (LDHD) protein expression.
[Signal Transduction And Targeted Therapy] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that glucose was a cofactor binding to methyltransferase NSUN2 at amino acid 1–28 to promote NSUN2 oligomerization and activation.
[Cell Metabolism] |
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| A near-infrared laser-induced synergistic therapeutic platform had been developed by incorporating aggregation-induced emission-active phototheranostic agents and sulfur dioxide prodrug into a biocompatible hydrogel to suppress malignant CSC growth.
[Advanced Science] |
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| To gain a deeper understanding of the role of Enhancer of Zeste homology 2 (Ezh2) in the early stages of mammary tumor progression, investigators employed an inducible mammary organoid system bearing conditional Ezh2 alleles that faithfully recapitulated key events of luminal B breast cancer initiation.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers presented compelling evidence that miR-30e-5p, a potential tumorsuppressive microRNA, exhibited significantly lower expression in acute myeloid leukemia samples compared to healthy bone marrow samples.
[Haematologica] |
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| Applying a genome-scale CRISPR knockout screen, scientists identified that the H3K4 methyltransferase SETD1A and other members of Trithorax group proteins drove cancer stemness in hepatocellular carcinoma.
[JCI Insight] |
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| Tspan15, ADAM10, and Notch1 expression and activation in fresh surgical specimens from 80 ICC patients and ICC cells were evaluated by immunohistochemistry, RT-PCR, western blotting, and flow cytometry.
[Liver International] |
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| The authors have evaluated the role of ERRα in the maintenance of breast cancer stem cells using breast cancer cell lines.
[Stem Cell Reviews and Reports] |
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| Breast cancer stem cell distribution was investigated using an integrated flow cytometry approach with the ALDEFLUORâ„¢ assay and CD24/CD44 antibodies.
[Frontiers in Cell and Developmental Biology] |
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| Investigators found that circABCC4 was highly expressed in prostate cancer (PCa) tissues and cells, and elevated circABCC4 level indicated a poor overall survival of PCa patients.
[Cancer Gene Therapy] |
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| To evaluate the presence of a neural-related DNA hypermethylation fingerprint in colon cancer and its relevance to carcinogenesis in general, the authors considered 16 solid cancer types available in The Cancer Genome Atlas.
[Epigenetics & Chromatin] |
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| To understand the effect of the underlying interaction of matrix stiffness and stemness on pancreatic ductal adenocarcinoma, a methacrylated gelatin hydrogel with tunable stiffness was applied for incubating MIA PaCa-2 and PANC-1 cells.
[ACS Biomaterials Science & Engineering] |
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| Both of the transgenic LGR5-diphtheria toxin receptor-GFP knock-in mice and transgenic Rosa26-mT mice developed primary liver tumors by diethylnitrosamine administration.
[Cancer Medicine] |
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| The authors summarize the current knowledge of CSC markers and stemness regulators in brain tumors.
[MedComm] |
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| The National Institutes of Health has awarded $2.6 million to a Virginia Tech team over five years for a study of high frequency irreversible electroporation (H-FIRE) for tumor ablation and immune system activation in cases of pancreatic cancer.
[Virginia Tech] |
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| A researcher at Southern Illinois University Carbondale will use a $445,500 federal grant to explore ways of turning off a genetic switch that allows rare but devasting cancer to progress in children.
[Southern Illinois University Carbondale] |
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| October 5 – 7, 2023
Boston, Massachusetts, United States |
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| | CRUK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | Stony Brook University – Stony Brook, New York, United States |
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| | Georgia Cancer Center at Augusta University – Augusta, Georgia, United States |
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| | Creative Biolabs – New York, New York, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
