Cancer Stem Cell News Volume 12.33 | Aug 23 2023

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    2023-08-23 | CSCN 12.33


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.33 – 23 August, 2023
    TOP STORY

    CD44+ Lung Cancer Stem Cell-Derived Pericyte-Like Cells Cause Brain Metastases through GPR124-Enhanced Trans-Endothelial Migration

    Researchers reported that vascular pericytes derived from CD44+ lung CSCs in lung adenocarcinoma potently caused brain metastases through the G-protein-coupled receptor 124 (GPR124)-enhanced trans-endothelial migration.
    [Cancer Cell]

    AbstractGraphical Abstract
    Guide to everything you need to know about cell separation.
    PUBLICATIONSRanked by the impact factor of the journal

    Zwitterionic Microgel Preservation Platform for Circulating Tumor Cells in Whole Blood Specimen

    Scientists established a zwitterionic magnetic microgel platform to stabilize whole blood specimen for long-term hypothermic preservation of model circulating tumor cells.
    [Nature Communications]

    Full Article

    Pyruvate Anaplerosis Is a Targetable Vulnerability in Persistent Leukemic Stem Cells

    Using clinically and physiologically relevant assays, investigators generated multi-omics datasets that offered unique insight into metabolic adaptation and nutrient fate in patient-derived chronic myeloid leukemia leukemic stem cells.
    [Nature Communications]

    Full ArticlePress Release

    Epigenetic and Molecular Coordination between HDAC2 and SMAD3-SKI Regulates Essential Brain Tumor Stem Cell Characteristics

    Using pharmacological inhibition and genetic loss and gain of function approaches, researchers identified histone deacetylase (HDAC) 2 as the most relevant histone deacetylase for re-organization of chromatin accessibility resulting in maintenance of brain tumor stem cell growth and self-renewal properties.
    [Nature Communications]

    Full Article

    Surgical Treatment of Osteosarcoma Induced Distant Pre-Metastatic Niche in Lung to Facilitate the Colonization of Circulating Tumor Cells

    Scientists investigated whether the pulmonary metastases characteristic of osteosarcoma was associated with surgical treatment and whether surgery contributed to the formation of pre-metastatic niche in the distant lung tissue.
    [Advanced Science]

    Full Article

    Photothermal Hyaluronic Acid Composite Hydrogel Targeting Cancer Stem Cells for Inhibiting Recurrence and Metastasis of Breast Cancer

    Researchers developed a local injectable hyaluronic acid composite hydrogel that targeted CSCs, which could continuously release all-trans retinoic acid and gold nanoparticles at tumor sites.
    [International Journal of Biological Macromolecules]

    Abstract

    Overcoming Multidrug Resistance by Reversan and Exterminating Glioblastoma and Glioblastoma Stem Cells by Delivering Drug-Loaded Nanostructure Hybrid Lipid Capsules (nHLCs)

    Investigators targeted P-glycoprotein using a small molecule inhibitor, reversan, to inhibit multidrug resistance that prolonged the retention of drugs in the cytosolic milieu.
    [Drug Delivery and Translational Research]

    AbstractGraphical Abstract

    Identification of Cancer Stemness and M2 Macrophage-Associated Biomarkers in Lung Adenocarcinoma

    Lung adenocarcinoma (LUAD) transcriptomic data was analyzed from The Cancer Genome Atlas (TCGA) as well as the Gene Expression Omnibus databases. Differential expression analysis was performed to discern abnormally expressed genes between LUAD and control samples in TCGA cohort.
    [Heliyon]

    Full Article

    METTL14 Suppresses Tumor Stemness and Metastasis of Colon Cancer Cells by Modulating m6A-Modified SCD1

    Bioinformatics data disclosed that methyltransferase-like 14 (METTL14) was significantly attenuated in colon cancer (CC). Functional assays were executed to ascertain how METTL14 affected CC tumorigenicity.
    [Molecular Biotechnology]

    Abstract
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    Circulating Tumor Cell-Derived Preclinical Models: Current Status and Future Perspectives

    The authors provide an overview of recent progress in the establishment of preclinical circulating tumor cell (CTC)-derived models, such as CTC-derived xenografts and cell cultures, which show promise for the study of CTCs.
    [Cell Death & Disease]

    Full Article
    INDUSTRY AND POLICY NEWS

    As Part of President Biden’s Unity Agenda, Biden Cancer Moonshot Announces Launch of ARPA-H’s CUREIT Project Led by Emory University to Develop New Tools to Strengthen the Immune System and Save Lives

    The Biden Cancer Moonshot is announcing the launch of “Curing the Uncurable via RNA-Encoded Immunogene Tuning” (CUREIT), a project that aims to develop generalizable mRNA platforms that can be harnessed to train the immune system to more effectively fight cancer and other diseases.
    [The White House]

    Press Release

    US Patent Granted Providing Broad Protection for BVX001

    BiVictriX Therapeutics plc announced that the United States Patent and Trademark Office has granted a patent providing broad protection for BVX001. The claims granted within this patent provides broad protection for the lead therapeutic asset, BVX001, at the antigen level.
    [BiVictriX]

    Press Release

    Cleveland Clinic-Led Team Awarded $2.8 Million to Translate Cancer Cell Evolution Research to Clinical Care

    The National Institutes of Health recently awarded Cleveland Clinic’s Jacob Scott, MD, DPhil, and collaborators $2.8 million to translate research on how cancer cells evolve and compete into patient care.
    [Cleveland Clinic]

    Press Release
    FEATURED EVENT

    SIOP 2023 Congress

    October 11 – 14, 2023
    Ottawa, Ontario, Canada

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    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Pathology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Research Fellow – Genito-Urinary Cancers

    University of South Australia – Adelaide, Australia

    Senior Scientific Officer – Initiation of Hepatocellular Carcinoma

    CRUK Beatson Institute – Glasgow, Scotland, United Kingdom

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    Principal Investigators – Molecular Cell Science

    Center for Excellence in Molecular Cell Science – Shanghai, China

    > See All Jobs

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