 | | Vol. 12.33 – 23 August, 2023 |
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| Researchers reported that vascular pericytes derived from CD44+ lung CSCs in lung adenocarcinoma potently caused brain metastases through the G-protein-coupled receptor 124 (GPR124)-enhanced trans-endothelial migration.
[Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists established a zwitterionic magnetic microgel platform to stabilize whole blood specimen for long-term hypothermic preservation of model circulating tumor cells.
[Nature Communications] |
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| Using clinically and physiologically relevant assays, investigators generated multi-omics datasets that offered unique insight into metabolic adaptation and nutrient fate in patient-derived chronic myeloid leukemia leukemic stem cells.
[Nature Communications] |
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| Using pharmacological inhibition and genetic loss and gain of function approaches, researchers identified histone deacetylase (HDAC) 2 as the most relevant histone deacetylase for re-organization of chromatin accessibility resulting in maintenance of brain tumor stem cell growth and self-renewal properties.
[Nature Communications] |
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| Scientists investigated whether the pulmonary metastases characteristic of osteosarcoma was associated with surgical treatment and whether surgery contributed to the formation of pre-metastatic niche in the distant lung tissue.
[Advanced Science] |
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| Researchers developed a local injectable hyaluronic acid composite hydrogel that targeted CSCs, which could continuously release all-trans retinoic acid and gold nanoparticles at tumor sites.
[International Journal of Biological Macromolecules] |
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| Investigators targeted P-glycoprotein using a small molecule inhibitor, reversan, to inhibit multidrug resistance that prolonged the retention of drugs in the cytosolic milieu.
[Drug Delivery and Translational Research] |
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| Lung adenocarcinoma (LUAD) transcriptomic data was analyzed from The Cancer Genome Atlas (TCGA) as well as the Gene Expression Omnibus databases. Differential expression analysis was performed to discern abnormally expressed genes between LUAD and control samples in TCGA cohort.
[Heliyon] |
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| Bioinformatics data disclosed that methyltransferase-like 14 (METTL14) was significantly attenuated in colon cancer (CC). Functional assays were executed to ascertain how METTL14 affected CC tumorigenicity.
[Molecular Biotechnology] |
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| The authors provide an overview of recent progress in the establishment of preclinical circulating tumor cell (CTC)-derived models, such as CTC-derived xenografts and cell cultures, which show promise for the study of CTCs.
[Cell Death & Disease] |
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| The Biden Cancer Moonshot is announcing the launch of “Curing the Uncurable via RNA-Encoded Immunogene Tuning” (CUREIT), a project that aims to develop generalizable mRNA platforms that can be harnessed to train the immune system to more effectively fight cancer and other diseases.
[The White House] |
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| BiVictriX Therapeutics plc announced that the United States Patent and Trademark Office has granted a patent providing broad protection for BVX001. The claims granted within this patent provides broad protection for the lead therapeutic asset, BVX001, at the antigen level.
[BiVictriX] |
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| The National Institutes of Health recently awarded Cleveland Clinic’s Jacob Scott, MD, DPhil, and collaborators $2.8 million to translate research on how cancer cells evolve and compete into patient care.
[Cleveland Clinic] |
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| October 11 – 14, 2023
Ottawa, Ontario, Canada |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | University of South Australia – Adelaide, Australia |
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| | CRUK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | Creative Biolabs – New York, New York, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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