 | | Vol. 12.35 – 6 September, 2023 |
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| Researchers identified Kunitz-type protease inhibitor TFPI2 as a critical factor connecting glioblastoma (GBM) stem cells and microglia and their associated GBM hallmarks of stemness and immunosuppression.
[Nature Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed lower levels of miR-142 in CD34+CD38− blasts from blast crisis (BC) chronic myeloid leukemia (CML) patients than in those from chronic phase CML patients, suggesting that miR-142 deficit was implicated in BC evolution.
[Nature Communications] |
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| Immunohistochemistry, The Cancer Genome Atlas, Gene Expression Omnibus, and other databases were used to analyze the expression of Jumonji and the AT-rich interaction domain-containing 2 (JARID2) in breast cancer cells.
[Cancer Communications] |
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| In cell lines and patient samples, scientists found that interleukin-33 (IL-33) signaling promoted stemness only in leukemia cells in a subtype-specific manner.
[Science Signaling] |
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| Researchers showed that the oncohistone regulated histone acetylation through ALDH1A3 in a Wnt-dependent manner and that loss of H3K27M expression resulted in sensitization of diffuse midline gliomas to radiotherapy.
[Neoplasia] |
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| The authors studied the relationship between Sry-box9 (SOX9) and prognosis of cervical cancer through public database, and SOX9 was related to poor prognosis of cervical cancer.
[FASEB Journal] |
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| Investigators employed a proximity-labeling proteomic approach to quantitatively analyze the cell-surface membrane proteins in close proximity to CD147 in CSCs.
[Scientific Reports] |
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| To characterize the function of B-cell lymphoma 7 protein family member B (BCL7B), heterozygous BCL7B-deficient stomach cancer cell lines were generated with the CRISPR/Cas9 genome editing system.
[BMC Cancer] |
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| Researchers found that human AlkB homolog H5 (ALKBH5) expression was enriched in liver cancer stem cells, which could foster proliferation, invasion, and migration of the hepatocellular carcinoma cells.
[Journal of Cancer Research and Clinical Oncology] |
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| Scientists immunohistochemically examined podoplanin expression in 87 cases of Bowen disease. Positive expression was detected in 64.4% of Bowen disease specimens, and the positive cells were exclusively located in the basal layer and corresponded to palisaded basal cells.
[Journal Of Dermatology] |
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| Investigators found that the enhancer of zeste homolog 2 (EZH2) was highly expressed in glioma and that its expression was correlated with the prognosis of glioblastoma multiforme in two databases: The Cancer Genome Atlas and the Chinese Glioma Genome Atlas.
[Experimental Brain Research] |
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| The authors reviewed some fundamental aspects of the most validated protein markers of stemness, autophagy, mitochondrial function, and energy metabolism in oral CSCs.
[Life Sciences] |
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| The Terry Fox Research Institute is awarding $2.4 million to the Spatial Metabolome Hubble Project. The Spatial Metabolomics Hub is led by Dr. Kyle Duncan, a Vancouver Island University (VIU) Chemistry Professor, and Dr. David Goodlett, Director of the University of Victoria’s Genome BC Proteomics Centre.
[Vancouver Island University] |
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| Unions representing University of California students, postdocs, and academic researchers allege repeated contract violations.
[Science] |
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| October 18 – 21, 2023
EMBL Heidelberg and Virtual |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | University of Cologne – Cologne, Germany |
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| | National Cancer Institute – Bethesda, Maryland, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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