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Vol. 12.35 – 6 September, 2023
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Researchers identified Kunitz-type protease inhibitor TFPI2 as a critical factor connecting glioblastoma (GBM) stem cells and microglia and their associated GBM hallmarks of stemness and immunosuppression.
[Nature Immunology]
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PUBLICATIONSRanked by the impact factor of the journal
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Investigators showed lower levels of miR-142 in CD34+CD38− blasts from blast crisis (BC) chronic myeloid leukemia (CML) patients than in those from chronic phase CML patients, suggesting that miR-142 deficit was implicated in BC evolution.
[Nature Communications]
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Immunohistochemistry, The Cancer Genome Atlas, Gene Expression Omnibus, and other databases were used to analyze the expression of Jumonji and the AT-rich interaction domain-containing 2 (JARID2) in breast cancer cells.
[Cancer Communications]
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In cell lines and patient samples, scientists found that interleukin-33 (IL-33) signaling promoted stemness only in leukemia cells in a subtype-specific manner.
[Science Signaling]
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Researchers showed that the oncohistone regulated histone acetylation through ALDH1A3 in a Wnt-dependent manner and that loss of H3K27M expression resulted in sensitization of diffuse midline gliomas to radiotherapy.
[Neoplasia]
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The authors studied the relationship between Sry-box9 (SOX9) and prognosis of cervical cancer through public database, and SOX9 was related to poor prognosis of cervical cancer.
[FASEB Journal]
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Investigators employed a proximity-labeling proteomic approach to quantitatively analyze the cell-surface membrane proteins in close proximity to CD147 in CSCs.
[Scientific Reports]
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To characterize the function of B-cell lymphoma 7 protein family member B (BCL7B), heterozygous BCL7B-deficient stomach cancer cell lines were generated with the CRISPR/Cas9 genome editing system.
[BMC Cancer]
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Researchers found that human AlkB homolog H5 (ALKBH5) expression was enriched in liver cancer stem cells, which could foster proliferation, invasion, and migration of the hepatocellular carcinoma cells.
[Journal of Cancer Research and Clinical Oncology]
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Scientists immunohistochemically examined podoplanin expression in 87 cases of Bowen disease. Positive expression was detected in 64.4% of Bowen disease specimens, and the positive cells were exclusively located in the basal layer and corresponded to palisaded basal cells.
[Journal Of Dermatology]
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Investigators found that the enhancer of zeste homolog 2 (EZH2) was highly expressed in glioma and that its expression was correlated with the prognosis of glioblastoma multiforme in two databases: The Cancer Genome Atlas and the Chinese Glioma Genome Atlas.
[Experimental Brain Research]
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The authors reviewed some fundamental aspects of the most validated protein markers of stemness, autophagy, mitochondrial function, and energy metabolism in oral CSCs.
[Life Sciences]
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The Terry Fox Research Institute is awarding $2.4 million to the Spatial Metabolome Hubble Project. The Spatial Metabolomics Hub is led by Dr. Kyle Duncan, a Vancouver Island University (VIU) Chemistry Professor, and Dr. David Goodlett, Director of the University of Victoria’s Genome BC Proteomics Centre.
[Vancouver Island University]
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Unions representing University of California students, postdocs, and academic researchers allege repeated contract violations.
[Science]
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October 18 – 21, 2023
EMBL Heidelberg and Virtual
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Francis Crick Institute – London, England, United Kingdom
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The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States
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University of Cologne – Cologne, Germany
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National Cancer Institute – Bethesda, Maryland, United States
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Cedars-Sinai – Los Angeles, California, United States
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Umbilical & Placental Cell News