Cancer Stem Cell News Volume 12.35 | Sept 06 2023


    2023-09-06 | CSCN 12.35

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.35 – 6 September, 2023

    Kunitz-Type Protease Inhibitor TFPI2 Remodels Stemness and Immunosuppressive Tumor Microenvironment in Glioblastoma

    Researchers identified Kunitz-type protease inhibitor TFPI2 as a critical factor connecting glioblastoma (GBM) stem cells and microglia and their associated GBM hallmarks of stemness and immunosuppression.
    [Nature Immunology]

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    Acquired miR-142 Deficit in Leukemic Stem Cells Suffices to Drive Chronic Myeloid Leukemia into Blast Crisis

    Investigators showed lower levels of miR-142 in CD34+CD38 blasts from blast crisis (BC) chronic myeloid leukemia (CML) patients than in those from chronic phase CML patients, suggesting that miR-142 deficit was implicated in BC evolution.
    [Nature Communications]

    Full Article

    JARID2 Coordinates with the NuRD Complex to Facilitate Breast Tumorigenesis through Response to Adipocyte-Derived Leptin

    Immunohistochemistry, The Cancer Genome Atlas, Gene Expression Omnibus, and other databases were used to analyze the expression of Jumonji and the AT-rich interaction domain-containing 2 (JARID2) in breast cancer cells.
    [Cancer Communications]

    Full Article

    IL-33–ST2 Signaling Promotes Stemness in Subtypes of Myeloid Leukemia Cells through the Wnt and Notch Pathways

    In cell lines and patient samples, scientists found that interleukin-33 (IL-33) signaling promoted stemness only in leukemia cells in a subtype-specific manner.
    [Science Signaling]

    Full Article

    Histone H3 K27M-Mediated Regulation of Cancer Cell Stemness and Differentiation in Diffuse Midline Glioma

    Researchers showed that the oncohistone regulated histone acetylation through ALDH1A3 in a Wnt-dependent manner and that loss of H3K27M expression resulted in sensitization of diffuse midline gliomas to radiotherapy.

    Full Article

    Upregulation of SOX9 Promotes the Self-Renewal and Tumorigenicity of Cervical Cancer through Activating the Wnt/β-Catenin Signaling Pathway

    The authors studied the relationship between Sry-box9 (SOX9) and prognosis of cervical cancer through public database, and SOX9 was related to poor prognosis of cervical cancer.
    [FASEB Journal]

    Full Article

    Lateral Interactions between CD276 and CD147 Are Essential for Stemness in Breast Cancer: A Novel Insight from Proximal Proteome Analysis

    Investigators employed a proximity-labeling proteomic approach to quantitatively analyze the cell-surface membrane proteins in close proximity to CD147 in CSCs.
    [Scientific Reports]

    Full Article

    BCL7B, a SWI/SNF Complex Subunit, Orchestrates Cancer Immunity and Stemness

    To characterize the function of B-cell lymphoma 7 protein family member B (BCL7B), heterozygous BCL7B-deficient stomach cancer cell lines were generated with the CRISPR/Cas9 genome editing system.
    [BMC Cancer]

    Full Article

    The ALKBH5/SOX4 Axis Promotes Liver Cancer Stem Cell Properties via Activating the SHH Signaling Pathway

    Researchers found that human AlkB homolog H5 (ALKBH5) expression was enriched in liver cancer stem cells, which could foster proliferation, invasion, and migration of the hepatocellular carcinoma cells.
    [Journal of Cancer Research and Clinical Oncology]

    AbstractGraphical Abstract

    Podoplanin-Positive Cells Located in the Basal Layer of Bowen Disease Include Tumor Cells with Cancer Stem Cell Properties

    Scientists immunohistochemically examined podoplanin expression in 87 cases of Bowen disease. Positive expression was detected in 64.4% of Bowen disease specimens, and the positive cells were exclusively located in the basal layer and corresponded to palisaded basal cells.
    [Journal Of Dermatology]


    Targeting EZH2 Regulates the Biological Characteristics of Glioma Stem Cells via the Notch1 Pathway

    Investigators found that the enhancer of zeste homolog 2 (EZH2) was highly expressed in glioma and that its expression was correlated with the prognosis of glioblastoma multiforme in two databases: The Cancer Genome Atlas and the Chinese Glioma Genome Atlas.
    [Experimental Brain Research]

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    Mitochondria in Oral Cancer Stem Cells: Unraveling the Potential Drug Targets for New and Old Drugs

    The authors reviewed some fundamental aspects of the most validated protein markers of stemness, autophagy, mitochondrial function, and energy metabolism in oral CSCs.
    [Life Sciences]


    VIU Professor Develops Imaging Technology to Take a Deeper Look at Tumor Metabolism

    The Terry Fox Research Institute is awarding $2.4 million to the Spatial Metabolome Hubble Project. The Spatial Metabolomics Hub is led by Dr. Kyle Duncan, a Vancouver Island University (VIU) Chemistry Professor, and Dr. David Goodlett, Director of the University of Victoria’s Genome BC Proteomics Centre.
    [Vancouver Island University]

    Press Release

    After Historic Strike, UC Grad Students Say University Isn’t Honoring Pay Agreements

    Unions representing University of California students, postdocs, and academic researchers allege repeated contract violations.


    Organoids: Modelling Organ Development and Disease in 3D Culture

    October 18 – 21, 2023
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    Laboratory Research Scientist – Human Normal and Leukemic Stem Cells

    Francis Crick Institute – London, England, United Kingdom

    Faculty Positions – Cancer Metastasis

    The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States

    Professorship – Familial Tumor Diseases

    University of Cologne – Cologne, Germany

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    National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

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