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Vol. 12.35 – 6 September, 2023
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Researchers identified Kunitz-type protease inhibitor TFPI2 as a critical factor connecting glioblastoma (GBM) stem cells and microglia and their associated GBM hallmarks of stemness and immunosuppression. [Nature Immunology]
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PUBLICATIONSRanked by the impact factor of the journal
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Investigators showed lower levels of miR-142 in CD34+CD38− blasts from blast crisis (BC) chronic myeloid leukemia (CML) patients than in those from chronic phase CML patients, suggesting that miR-142 deficit was implicated in BC evolution. [Nature Communications]
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Immunohistochemistry, The Cancer Genome Atlas, Gene Expression Omnibus, and other databases were used to analyze the expression of Jumonji and the AT-rich interaction domain-containing 2 (JARID2) in breast cancer cells.
[Cancer Communications]
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In cell lines and patient samples, scientists found that interleukin-33 (IL-33) signaling promoted stemness only in leukemia cells in a subtype-specific manner.
[Science Signaling]
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Researchers showed that the oncohistone regulated histone acetylation through ALDH1A3 in a Wnt-dependent manner and that loss of H3K27M expression resulted in sensitization of diffuse midline gliomas to radiotherapy.
[Neoplasia]
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The authors studied the relationship between Sry-box9 (SOX9) and prognosis of cervical cancer through public database, and SOX9 was related to poor prognosis of cervical cancer.
[FASEB Journal]
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Investigators employed a proximity-labeling proteomic approach to quantitatively analyze the cell-surface membrane proteins in close proximity to CD147 in CSCs.
[Scientific Reports]
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To characterize the function of B-cell lymphoma 7 protein family member B (BCL7B), heterozygous BCL7B-deficient stomach cancer cell lines were generated with the CRISPR/Cas9 genome editing system.
[BMC Cancer]
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Researchers found that human AlkB homolog H5 (ALKBH5) expression was enriched in liver cancer stem cells, which could foster proliferation, invasion, and migration of the hepatocellular carcinoma cells.
[Journal of Cancer Research and Clinical Oncology]
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Scientists immunohistochemically examined podoplanin expression in 87 cases of Bowen disease. Positive expression was detected in 64.4% of Bowen disease specimens, and the positive cells were exclusively located in the basal layer and corresponded to palisaded basal cells.
[Journal Of Dermatology]
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Investigators found that the enhancer of zeste homolog 2 (EZH2) was highly expressed in glioma and that its expression was correlated with the prognosis of glioblastoma multiforme in two databases: The Cancer Genome Atlas and the Chinese Glioma Genome Atlas. [Experimental Brain Research]
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The authors reviewed some fundamental aspects of the most validated protein markers of stemness, autophagy, mitochondrial function, and energy metabolism in oral CSCs. [Life Sciences]
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The Terry Fox Research Institute is awarding $2.4 million to the Spatial Metabolome Hubble Project. The Spatial Metabolomics Hub is led by Dr. Kyle Duncan, a Vancouver Island University (VIU) Chemistry Professor, and Dr. David Goodlett, Director of the University of Victoria’s Genome BC Proteomics Centre.
[Vancouver Island University]
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Unions representing University of California students, postdocs, and academic researchers allege repeated contract violations. [Science]
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October 18 – 21, 2023
EMBL Heidelberg and Virtual
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Francis Crick Institute – London, England, United Kingdom
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The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States
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University of Cologne – Cologne, Germany
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National Cancer Institute – Bethesda, Maryland, United States
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Cedars-Sinai – Los Angeles, California, United States
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