Cancer Stem Cell News Volume 12.36 | Sept 13 2023

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    2023-09-13 | CSCN 12.36


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.36 – 13 September, 2023
    TOP STORY

    Gelatin-Based 3D Biomimetic Scaffolds Platform Potentiates Culture of Cancer Stem Cells in Esophageal Squamous Cell Carcinoma

    Researchers established gelatin-based 3D biomimetic scaffolds mimicking the stiffness and collagen content of esophageal squamous cell carcinoma (ESCC), which could enrich ESCC CSCs efficiently.
    [Biomaterials]

    AbstractGraphical Abstract
    Learn how to be a great STEM mentor to new lab members
    PUBLICATIONSRanked by the impact factor of the journal

    Nimbolide Based Nanomedicine Inhibits Cancer Stem-Like Cells by Epigenetic Reprogramming of DNMTs-SFRP1-Wnt/β-Catenin Signaling Axis in Triple-Negative Breast Cancer

    The authors investigated nimbolide, a limonoid triterpenoid that has potent anticancer properties but poor pharmacokinetics and low bioavailability limit its therapeutic application.
    [Molecular Therapy-Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    The Regulatory Role of Cancer Stem Cell Marker Gene CXCR4 in the Growth and Metastasis of Gastric Cancer

    Scientists revealed the molecular mechanism of the CSCs marker gene C-X-C chemokine receptor type 4 (CXCR4) in gastric cancer growth and metastasis through scRNA-seq combined with bulk RNA-seq.
    [npj Precision Oncology]

    Full Article

    B4GALNT1 Promotes Hepatocellular Carcinoma Stemness and Progression via Integrin α2β1-Mediated FAK and AKT Activation

    Immunohistochemical staining was used to evaluate β-1,4-N-Acetyl-Galactosaminyltransferase 1 (B4GALNT1) expression in hepatocellular carcinoma tissues and adjacent normal liver tissues.
    [JHEP Reports]

    Full ArticleGraphical Abstract

    Machine Learning-Identified Stemness Features and Constructed Stemness-Related Subtype with Prognosis, Chemotherapy, and Immunotherapy Responses for Non-Small Cell Lung Cancer Patients

    Four machine learning methods were used to construct and validate a stemness subtype classification model, and cell function experiments were performed to verify the effect of the signature gene ARTN on non-small cell lung cancer.
    [Stem Cell Research & Therapy]

    Full Article

    Neddylation-Dependent LSD1 Destabilization Inhibits the Stemness and Chemoresistance of Gastric Cancer

    Neural precursor cell-expressed developmentally down-regulated protein 8 was identified to be conjugated to lysine-specific demethylase 1 (LSD1) at K63 by ubiquitin-conjugating enzyme E2 M.
    [International Journal of Biological Macromolecules]

    Abstract

    Single Cell Phenotypic Analysis for Cancer Stem Cell Identification by Dual-Isotope ICP-QMS

    Investigators reported a new approach based on dual-isotope inductively coupled plasma quadrupole mass spectrometry (ICP-QMS) for single cell phenotypic analysis.
    [Analytical Chemistry]

    AbstractGraphical Abstract

    Exosome-Derived miR-372-5p Promotes Stemness and Metastatic Ability of CRC Cells by Inducing Macrophage Polarization

    Researchers used miRNA-seq technology to screen out the highly expressed miR-372-5p among the miRNAs differentially expressed in plasma exosomes of clinical colorectal cancer (CRC) patients.
    [Cellular Signalling]

    Abstract

    Histone Demethylase KDM6A Coordinating with KMT2B Regulates Self-Renewal and Chemoresistance of Non-Small Cell Lung Cancer Stem Cells

    Gene set enrichment analysis and immunohistochemistry were performed to establish the correlation between histone lysine demethylase 6A (KDM6A)/lysin methyltransferase 2B (KMT2B) and CSC stemness.
    [Translational Oncology]

    Full Article

    Suspension State Affects the Stemness of Breast Cancer Cells by Regulating the Glycogen Synthase Kinase-3β

    MCF-7 and MDA-MBA-231 breast cancer cells (BCCs) were cultured in suspension and adherent. The effect of suspension state on BCCs was further elucidated by observing suspension cell clusters, sorting CD44+/CD24 cell subpopulation, and detecting self-renewal ability.
    [Tissue and Cell]

    Abstract
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    REVIEWS

    Update on Immune-Based Therapy Strategies Targeting Cancer Stem Cells

    The authors review the targeting of CSCs by immunotherapy strategies such as dendritic cell vaccines, chimeric antigen receptors-engineered immune cells, natural killer-cell therapy, monoclonal antibodies, and more.
    [Cancer Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Moderna and Immatics Announce Strategic Multi-Platform Collaboration to Develop Innovative Oncology Therapeutics

    Moderna, Inc. and Immatics N.V. announced a strategic research and development collaboration to pioneer novel and transformative therapies for cancer patients with high unmet medical need.
    [Immatics]

    Press Release

    Mount Sinai Awarded $3.4 Million to Study Prostate Cancer in People with HIV

    The National Cancer Institute has awarded the Icahn School of Medicine at Mount Sinai a $3.4 million grant to create a model that identifies the best prostate cancer treatment for people with HIV.
    [Mount Sinai]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Brain Cancer

    October 19 – 22, 2023
    Minneapolis, Minnesota, United States

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    JOB OPPORTUNITIES

    Principal Investigators – Molecular Cell Science

    Chinese Academy of Sciences – Shanghai, China

    Assistant Professor – Cancer, Cardiovascular and Metabolic Health, or Brain, Mind, and Behavior

    Northwestern University – Chicago, Illinois, United States

    Postdoctoral Research Fellow – Pathology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Research Fellow – Genito-Urinary Cancers

    University of South Australia – Adelaide, Australia

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    > See All Jobs

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