 | | Vol. 12.36 – 13 September, 2023 |
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| Researchers established gelatin-based 3D biomimetic scaffolds mimicking the stiffness and collagen content of esophageal squamous cell carcinoma (ESCC), which could enrich ESCC CSCs efficiently.
[Biomaterials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors investigated nimbolide, a limonoid triterpenoid that has potent anticancer properties but poor pharmacokinetics and low bioavailability limit its therapeutic application.
[Molecular Therapy-Nucleic Acids] |
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| Scientists revealed the molecular mechanism of the CSCs marker gene C-X-C chemokine receptor type 4 (CXCR4) in gastric cancer growth and metastasis through scRNA-seq combined with bulk RNA-seq.
[npj Precision Oncology] |
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| Immunohistochemical staining was used to evaluate β-1,4-N-Acetyl-Galactosaminyltransferase 1 (B4GALNT1) expression in hepatocellular carcinoma tissues and adjacent normal liver tissues.
[JHEP Reports] |
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| Four machine learning methods were used to construct and validate a stemness subtype classification model, and cell function experiments were performed to verify the effect of the signature gene ARTN on non-small cell lung cancer.
[Stem Cell Research & Therapy] |
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| Neural precursor cell-expressed developmentally down-regulated protein 8 was identified to be conjugated to lysine-specific demethylase 1 (LSD1) at K63 by ubiquitin-conjugating enzyme E2 M.
[International Journal of Biological Macromolecules] |
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| Investigators reported a new approach based on dual-isotope inductively coupled plasma quadrupole mass spectrometry (ICP-QMS) for single cell phenotypic analysis.
[Analytical Chemistry] |
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| Researchers used miRNA-seq technology to screen out the highly expressed miR-372-5p among the miRNAs differentially expressed in plasma exosomes of clinical colorectal cancer (CRC) patients.
[Cellular Signalling] |
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| Gene set enrichment analysis and immunohistochemistry were performed to establish the correlation between histone lysine demethylase 6A (KDM6A)/lysin methyltransferase 2B (KMT2B) and CSC stemness.
[Translational Oncology] |
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| MCF-7 and MDA-MBA-231 breast cancer cells (BCCs) were cultured in suspension and adherent. The effect of suspension state on BCCs was further elucidated by observing suspension cell clusters, sorting CD44+/CD24– cell subpopulation, and detecting self-renewal ability.
[Tissue and Cell] |
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| The authors review the targeting of CSCs by immunotherapy strategies such as dendritic cell vaccines, chimeric antigen receptors-engineered immune cells, natural killer-cell therapy, monoclonal antibodies, and more.
[Cancer Medicine] |
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| Moderna, Inc. and Immatics N.V. announced a strategic research and development collaboration to pioneer novel and transformative therapies for cancer patients with high unmet medical need.
[Immatics] |
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| The National Cancer Institute has awarded the Icahn School of Medicine at Mount Sinai a $3.4 million grant to create a model that identifies the best prostate cancer treatment for people with HIV.
[Mount Sinai] |
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| October 19 – 22, 2023
Minneapolis, Minnesota, United States |
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| | Chinese Academy of Sciences – Shanghai, China |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | University of South Australia – Adelaide, Australia |
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| | Creative Biolabs – New York, New York, United States |
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