Cancer Stem Cell News Volume 12.38 | Sept 27 2023

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    2023-09-27 | CSCN 12.38


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.38 – 27 September, 2023
    TOP STORY

    BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma

    By small molecule compound screening targeting 142 epigenetic enzymes, investigators identified that bromodomain-containing protein BRD9 was a key chromatin regulator to orchestrate the stemness of pancreatic CSCs.
    [Gastroenterology]

    AbstractFull ArticlePress Release
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    SCARB2 Drives Hepatocellular Carcinoma Tumor Initiating Cells via Enhanced MYC Transcriptional Activity

    Scientists performed a metabolic gene CRISPR/Cas9 knockout library screen in tumorspheres derived from hepatocellular carcinoma (HCC) cells and found that deletion of scavenger receptor class B member 2 (SCARB2) suppressed the cancer stem cell-like properties of HCC cells.
    [Nature Communications]

    Full Article

    Crosstalk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells

    Researchers identified that poly(A)-specific ribonuclease (PARN), a key modulator of RNA metabolism, activated EGFR-STAT3 signaling to support glioblastoma stem cells.
    [Cancer Research]

    Abstract

    Post-Translational Modification of CDK1–STAT3 Signaling by Fisetin Suppresses Pancreatic Cancer Stem Cell Properties

    The authors demonstrated that CDK1 was correlated with prognosis and was highly expressed in pancreatic cancer tissue and gemcitabine-resistant cells.
    [Cell & Bioscience]

    Full Article

    A Novel SLC25A1 Inhibitor, Parthenolide, Suppresses the Growth and Stemness of Liver Cancer Stem Cells with Metabolic Vulnerability

    Scientists showed that administration of parthenolide stimulated cell cycle arrest at the G1 phase, induced apoptosis, and decreased the stemness of liver CSCs.
    [Cell Death Discovery]

    Full ArticleGraphical Abstract

    Notum Enhances Gastric Cancer Stem-Like Cell Properties through Upregulation of Sox2 by PI3K/AKT Signaling Pathway

    Bioinformatics analysis, RT-qPCR, western blot and imunohistochemistry staining were applied to characterize Notum expression in gastric cancer specimens. The early diagnostic value of Notum was analyzed by logistic regression analysis method.
    [Cellular Oncology]

    Full Article

    The Role of LOXL2 Induced by Glucose Metabolism-Activated NF-κB in Maintaining Drug Resistance through EMT and Cancer Stemness in Gemcitabine-Resistant PDAC

    Researchers investigated the mechanism of lysyl oxide-like 2 (LOXL2) induction and the effect of LOXL2 on epithelial to mesenchymal transition (EMT) and CSC in gemcitabine-resistant pancreatic cancer.
    [Journal Of Molecular Medicine]

    Full Article

    Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR

    Investigators showed that rosmarinic acid was cytotoxic against human Daoy and D283 medulloblastoma cells.
    [Neuromolecular Medicine]

    Abstract

    USP10 Promotes Intrahepatic Cholangiocarcinoma Cell Survival and Stemness via SNAI1 Deubiquitination

    Scientists revealed that ubiquitin specific peptidase 10 (USP10) attenuated intrahepatic cholangiocarcinoma cell malignancy by deubiquitinating snail family transcriptional repressor 1 (SNAI1).
    [Journal of Molecular Histology]

    Abstract

    YAP1 Affects the Prognosis through the Regulation of Stemness in Endometrial Cancer

    Researchers collected specimens and clinical data from 774 patients with endometrial cancer to analyze the correlation between YAP1 expression and prognosis.
    [Peerj Life & Environment]

    Full Article
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    REVIEWS

    Stemness Markers in Hepatocellular Carcinoma of Eastern vs. Western Population: Etiology Matters?

    The authors summarize available data regarding whether various hepatocellular carcinoma etiologies are associated with the appearance of CSC biomarkers.
    [Annals of Hepatology]

    Full Article
    INDUSTRY AND POLICY NEWS

    New Scientific Partnership between UK and France to Tackle Greatest Challenges in Cancer

    Cancer Research UK and France’s Institut National Du Cancer announced a new scientific partnership to help fund world-class researchers to take on cancer’s toughest challenges through the global Cancer Grand Challenges initiative.
    [Cancer Research UK]

    Press Release

    ARPA-H Launches ARPANET-H: A Nationwide Health Innovation Network

    ARPANET-H is a nationwide health innovation network that connects people, innovators, and institutions. This network is anchored by three regional hubs.
    [ARPA-H]

    Press Release
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    JOB OPPORTUNITIES

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    Baylor College of Medicine – Houston, Texas, United States

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    University of Houston – Houston, Texas, United States

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