 | | Vol. 12.38 – 27 September, 2023 |
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| By small molecule compound screening targeting 142 epigenetic enzymes, investigators identified that bromodomain-containing protein BRD9 was a key chromatin regulator to orchestrate the stemness of pancreatic CSCs.
[Gastroenterology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed a metabolic gene CRISPR/Cas9 knockout library screen in tumorspheres derived from hepatocellular carcinoma (HCC) cells and found that deletion of scavenger receptor class B member 2 (SCARB2) suppressed the cancer stem cell-like properties of HCC cells.
[Nature Communications] |
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| Researchers identified that poly(A)-specific ribonuclease (PARN), a key modulator of RNA metabolism, activated EGFR-STAT3 signaling to support glioblastoma stem cells.
[Cancer Research] |
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| The authors demonstrated that CDK1 was correlated with prognosis and was highly expressed in pancreatic cancer tissue and gemcitabine-resistant cells.
[Cell & Bioscience] |
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| Scientists showed that administration of parthenolide stimulated cell cycle arrest at the G1 phase, induced apoptosis, and decreased the stemness of liver CSCs.
[Cell Death Discovery] |
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| Bioinformatics analysis, RT-qPCR, western blot and imunohistochemistry staining were applied to characterize Notum expression in gastric cancer specimens. The early diagnostic value of Notum was analyzed by logistic regression analysis method.
[Cellular Oncology] |
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| Researchers investigated the mechanism of lysyl oxide-like 2 (LOXL2) induction and the effect of LOXL2 on epithelial to mesenchymal transition (EMT) and CSC in gemcitabine-resistant pancreatic cancer.
[Journal Of Molecular Medicine] |
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| Investigators showed that rosmarinic acid was cytotoxic against human Daoy and D283 medulloblastoma cells.
[Neuromolecular Medicine] |
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| Scientists revealed that ubiquitin specific peptidase 10 (USP10) attenuated intrahepatic cholangiocarcinoma cell malignancy by deubiquitinating snail family transcriptional repressor 1 (SNAI1).
[Journal of Molecular Histology] |
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| Researchers collected specimens and clinical data from 774 patients with endometrial cancer to analyze the correlation between YAP1 expression and prognosis.
[Peerj Life & Environment] |
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| The authors summarize available data regarding whether various hepatocellular carcinoma etiologies are associated with the appearance of CSC biomarkers.
[Annals of Hepatology] |
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| Cancer Research UK and France’s Institut National Du Cancer announced a new scientific partnership to help fund world-class researchers to take on cancer’s toughest challenges through the global Cancer Grand Challenges initiative.
[Cancer Research UK] |
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| ARPANET-H is a nationwide health innovation network that connects people, innovators, and institutions. This network is anchored by three regional hubs.
[ARPA-H] |
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| October 29 – November 1, 2023
New York, New York, United States |
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| | University of California, San Francisco – San Francisco, California, United States |
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| | University of Michigan-Ann Arbor – Ann Arbor, Michigan, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Houston – Houston, Texas, United States |
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| | King’s College London – London, England, United Kingdom |
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