Cancer Stem Cell News Volume 12.41 | Nov 8 2023


    2023-11-08 | CSCN 12.41

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.41 – 8 November, 2023

    Metabolic Dependencies of Metastasis-Initiating Cells in Female Breast Cancer

    The authors examined the metabolic adaptations of metastasis-initiating cells in female breast cancer and how those shape their metastatic phenotype.
    [Nature Communications]

    Full Article
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    Stem Cell–Like Reprogramming Is Required for Leukemia-Initiating Activity in B-ALL

    Researchers used the PAX5::ELN oncogenic model to demonstrate a causal link between the differentiation blockade, the self-renewal, and the emergence of pre-leukemic stem cells.
    [Journal of Experimental Medicine]


    Nebulized Therapy of Early Orthotopic Lung Cancer by Iron-Based Nanoparticles: Macrophage-Regulated Ferroptosis of Cancer Stem Cells

    Scientists developed a nebulized nanocatalytic medicine strategy in which iron-based nanoparticle-regulated tumor-associated macrophages effectively target CSC niches and trigger CSC ferroptosis in the early stage of lung cancer.
    [Journal Of The American Chemical Society]

    AbstractGraphical Abstract

    The STEMRI Trial: Magnetic Resonance Spectroscopy Imaging Can Define Tumor Areas Enriched in Glioblastoma Stem-Like Cells

    Biopsy and derived-glioblastoma stem-like cell (GSC) characterization revealed a FLAIR/CNI+ sample enrichment in GSC and in gene signatures related to stemness, DNA repair, adhesion/migration, and mitochondrial bioenergetics.
    [Science Advances]

    Full Article

    Claudin-1 Interacts With EPHA2 To Promote Cancer Stemness and Chemoresistance in Colorectal Cancer

    Scientists found that high Claudin-1 expression in colorectal cancer was associated with cancer stemness and chemoresistance signaling pathways in patient datasets, and it promotes chemoresistance both in vitro and in vivo.
    [Cancer Letters]

    AbstractGraphical Abstract

    SAA Suppresses α-PD-1 Induced Anti-Tumor Immunity by Driving TH2 Polarization in Lung Adenocarcinoma

    The authors used single cell RNA sequence technology to identify the characteristic of CSCs. They found that the lung adenocarcinoma cancer stem population was highly inflammatory and remodeled the tumor microenvironment.
    [Cell Death & Disease]

    Full Article

    Combined In Vitro/In Vivo Genome-Wide CRISPR Screens in Triple Negative Breast Cancer Identify Cancer Stemness Regulators in Paclitaxel Resistance

    Scientists reported a combined in vitro/in vivo genome-wide CRISPR synthetic lethality screening approach in a relevant triple-negative breast cancer cell line model to identify several targets responsible for the chemotherapy drug, paclitaxel resistance.

    Full Article

    PCBP1 Regulates LIFR Through FAM3C To Maintain Breast Cancer Stem Cell Self-Renewal and Invasiveness

    Investigators characterized feed-forward regulation of leukemia inhibitory factor receptor (LIFR) expression in response to FAM3C/LIFR/STAT3 signaling in mammary epithelial cells.
    [Cancer Biology & Therapy]

    Full Article

    Cancer Stemness Kinase Inhibitor Amcasertib: A Promising Therapeutic Agent in Ovarian Cancer Stem and Cancer Cell Models With Different Genetic Profiles

    Researchers evaluated the antineoplastic effects of Nanog inhibition, a critical transcription factor associated with pluripotency and its role in ovarian cancer tumorigenesis, using the novel therapeutic agent Amcasertib in ovarian cancer cells.
    [Medical Oncology]

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    Tumor Microenvironment: A Niche for Cancer Stem Cell Immunotherapy

    Investigators explored novel avenues of research that delve into the distinctive characteristics of CSCs within their surrounding tumor microenvironment.
    [Stem Cell Reviews And Reports]

    AbstractPress Release

    Deborah Lang, PhD, Receives Grant To Examine How Some Genes Are Disrupted at the DNA, RNA Level, Cause Melanoma

    Dr. Deborah Lang has been awarded a two-year, $300,000 Discovery Boost Grant from the American Cancer Society for her research project “Exploring roles for PAX3 in regulating gene expression on a post-transcriptional level.”
    [Boston University]

    Press Release

    Vienna International Symposium

    December 4 – 6, 2023
    Vienna, Austria

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    Postdoctoral Scholar – Genitourinary Malignancies

    The Ohio State University – Columbus, Ohio, United States

    Postdoctoral Fellow – Cell Biology

    Danish Cancer Society – Copenhagen, Hovedstaden

    Postdoctoral Associate – Brain Tumor Research

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Assistant/Associate Professor – Prostate Cancer

    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    > See All Jobs

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