Cancer Stem Cell News Volume 12.42 | Nov 15 2023

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    2023-11-15 | CSCN 12.42


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.42 – 15 November, 2023
    TOP STORY

    Entirely Noninvasive Outcome Prediction in Central Nervous System Lymphomas Using Circulating Tumor DNA

    Scientists applied ultrasensitive circulating tumor DNA sequencing to 146 plasma and cerebrospinal fluid samples from 67 patients, to develop an entirely noninvasive dynamic risk model considering clinical and molecular features of central nervous system lymphoma.
    [Blood]

    Abstract
    Resources for Your T Cell Therapy Research
    PUBLICATIONSRanked by the impact factor of the journal

    Tumor Cell-Induced Macrophage Senescence Plays a Pivotal Role in Tumor Initiation Followed by Stable Growth in Immunocompetent Condition

    Researchers identified one of the requirements for tumor-initiating cells in immunocompetent animals. In addition, they have showed that tumor growth could be inhibited by externally administered nicotinamide mononucleotide against macrophage senescence-like state.
    [Journal For Immunotherapy Of Cancer]

    Full ArticlePress Release

    Extended Exposure to Low Doses of Azacitidine Induces Differentiation of Leukemic Stem Cells through Activation of Myeloperoxidase

    In leukemic stem cell (LSC) models, the extended dose of azacitidine induced differentiation and depleted CD34+CD38 LSCs.
    [Haematologica]

    Abstract

    LncRNA MIR31HG Fosters Stemness Malignant Features of Non-Small Cell Lung Cancer via H3K4me1- and H3K27Ace-Mediated GLI2 Expression

    Functional analysis showed that MIR31HG fostered stemness-associated malignant features of non-small cell lung cancer cells.
    [Oncogene]

    Full ArticleGraphical Abstract

    Endoplasmic Reticulum Regulation of Glucose Metabolism in Glioma Stem Cells

    Researchers indicated that endoplasmic reticulum‑mitochondrial homeostasis was essential for regulation of glioma initiating cells glucose metabolism and survival.
    [International Journal of Oncology]

    Abstract

    Orai1α and Orai1β Support Calcium Entry and Mammosphere Formation in Breast Cancer Stem Cells

    Scientists reported, for the first time, the expression profile of the Orai family members, Orai1-3, and different TRPC channels, TRPC1, 3 and 6, in breast CSCs.
    [Scientific Reports]

    Full Article

    SETD5 Regulates the OGT-Catalyzed O-GlcNAcylation of RNA Polymerase II, Which Is Involved in the Stemness of Colorectal Cancer Cells

    Investigators showed that aberrant SET-domain-containing protein 5 (SETD5) overexpression induced stemness in colorectal cancer cells.
    [Scientific Reports]

    Full Article

    Downregulation of TAB182 Promotes Cancer Stem-Like Cell Properties and Therapeutic Resistance in Triple-Negative Breast Cancer Cells

    The authors revealed a novel function of TAB182 as a potential negative regulator of cancer stem-like properties and drug sensitivity in triple-negative breast cancer cells.
    [BMC Cancer]

    Full Article

    Circular RNA ZNF800 (hsa_circ_0082096) Regulates Cancer Stem Cell Properties and Tumor Growth in Colorectal Cancer

    Scientists determined that CircZNF800 was an oncogenic factor that regulated CSC properties which led to colorectal tumorigenesis.
    [BMC Cancer]

    Full Article
    Explore tools and resources for your return to the lab
    REVIEWS

    Clonal Tracking in Cancer and Metastasis

    The authors describe viral-based and CRISPR-Cas9-based cellular barcoding, lineage tracing, and imaging-based approaches.
    [Cancer and Metastasis Reviews]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Three Investigators Named Winners of Memorial Sloan Kettering Cancer Center’s 2023 Paul Marks Prize for Cancer Research

    Memorial Sloan Kettering Cancer Center has announced three innovative investigators as the recipients of this year’s Paul Marks Prize for Cancer Research.
    [Memorial Sloan Kettering Cancer Center]

    Press Release
    FEATURED EVENT

    2023 San Antonio Breast Cancer Symposium

    December 5 – 9, 2023
    San Antonio, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Positions – Cancer Research Center

    German Cancer Research Center in the Helmholtz Association – Heideland, Germany

    Postdoctoral Fellowships – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral Scholar – Genitourinary Malignancies

    The Ohio State University – Columbus, Ohio, United States

    Postdoctoral Fellow – Cell Biology

    Danish Cancer Society – Copenhagen, Hovedstaden

    Postdoctoral Associate – Brain Tumor Research

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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