Cancer Stem Cell News Volume 12.43 | Nov 22 2023


    2023-11-22 | CTN 12.43

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.43 – 22 November, 2023

    BMI1 Silencing Liposomes Suppress Postradiotherapy Cancer Stemness against Radioresistant Hepatocellular Carcinoma

    Researchers clarified the relationship between radiotherapy and cancer stemness and provided insights to achieve complete suppression of radioresistant hepatocellular carcinoma tumors by inhibiting cancer stemness.
    [ACS Nano]

    AbstractGraphical Abstract
    Use STEMvision™ for Automated Hematopoietic CFU Assay Imaging & Analysis.
    PUBLICATIONSRanked by the impact factor of the journal

    LncRNA INHEG Promotes Glioma Stem Cell Maintenance and Tumorigenicity through Regulating rRNA 2′-O-methylation

    Investigators reported that the lncRNA INHEG was highly expressed in glioma stem cells (GSCs) compared to differentiated glioma cells and promoted GSC self-renewal and tumorigenicity through control of rRNA 2’-O-methylation.
    [Nature Communications]

    Full Article

    Stabilizing Vimentin Phosphorylation Inhibits Stem-Like Cell Properties and Metastasis of Hybrid Epithelial/Mesenchymal Carcinomas

    Scientists identified that stabilizing vimentin phosphorylation at serine 56 induces multinucleation, specifically in hybrid epithelial-mesenchymal cells with stemness properties but not epithelial or mesenchymal cells.
    [Cell Reports]

    Full ArticleGraphical Abstract

    mTOR Inhibition Suppresses Salinomycin-Induced Ferroptosis in Breast Cancer Stem Cells by Ironing Out Mitochondrial Dysfunctions

    In a well-established breast cancer stem cells model, investigators identified that pharmacological inhibition of the mechanistic target of rapamycin (mTOR), suppressed Sal-induced ferroptosis.
    [Cell Death & Disease]

    Full ArticleGraphical Abstract

    Disseminating Cells in Human Oral Tumors Possess an EMT Cancer Stem Cell Marker Profile That Is Predictive of Metastasis in Image-Based Machine Learning

    Researchers investigated whether the combination of three markers, EpCAM, CD24, and Vimentin, could identify disseminating epithelial-mesenchymal transition CSCs in actual human tumors.


    Transcription Factor LHX9 (LIM Homeobox 9) Enhances Pyruvate Kinase PKM2 Activity to Induce Glycolytic Metabolic Reprogramming in Cancer Stem Cells, Promoting Gastric Cancer Progression

    Scientists revealed the critical mediators that regulated glycolytic metabolism reprogramming in gastric cancer and their underlying molecular mechanism.
    [Journal of Translational Medicine]

    Full Article

    Direct Tumor Irradiation Potentiates Adoptive NK Cell Targeting against Parental and Stem-Like Cancer in Human Liver Cancer Models

    The authors found that NK cells in combination with tumor irradiation may provide synergistic therapeutic effects for NK cell recognition and elimination against both parental and stem-like liver cancer through lymphocyte function-associated antigen 1/intercellular adhesion molecule-1.
    [International Journal Of Radiation Oncology Biology Physics]


    YTHDF1 Enhances Stemness and Chemoresistance in Triple-Negative Breast Cancer Cells by Upregulating SIAH2

    Knockdown of YTHDF1 and SIAH2, or overexpression of seven in absentia homology 2 (SIAH2) in vitro and in vivo, was conducted to evaluate the impact of changes in YTHDF1 and SIAH2 expression on triple-negative breast cancer cell proliferation, apoptosis, stemness, and Hippo pathway gene expression.
    [Molecular Carcinogenesis]

    Full Article

    ALDH2 Dysfunction and Alcohol Cooperate in Cancer Stem Cell Enrichment

    Investigators characterized how esophageal squamous cell carcinoma and preneoplastic cells respond to alcohol exposure using cell lines, three-dimensional organoids, and xenograft models.

    AbstractGraphical Abstract
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.

    Purinergic System in Cancer Stem Cells

    Scientists discuss updated information regarding CSCs in the purinergic system and present evidence supporting the idea that elements of the purinergic system expressed by this subpopulation of the tumor represent attractive pharmacological targets for proposing innovative anti-cancer therapies.
    [Purinergic Signalling]

    Full Article

    Bishoy M. Faltas Receives Prestigious MERIT Grant

    Dr. Bishoy M. Faltas, director of bladder cancer research at the Englander Institute for Precision Medicine at Weill Cornell Medicine has been awarded a $4 million, seven-year MERIT grant from the National Cancer Institute at the National Institutes of Health.
    [Weill Cornell Medicine]

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    Assistant Professor Position – 3D Tissue Organoids

    Swammerdam Institute for Life Sciences – Amsterdam, Netherlands

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    Babraham Institute – Cambridge, England, United Kingdom

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    University of Oxford – Oxford, England, United Kingdom

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    NIH National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral Scholar – Genitourinary Malignancies

    The Ohio State University – Columbus, Ohio, United States

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