 | | Vol. 12.43 – 22 November, 2023 |
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| Researchers clarified the relationship between radiotherapy and cancer stemness and provided insights to achieve complete suppression of radioresistant hepatocellular carcinoma tumors by inhibiting cancer stemness.
[ACS Nano] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported that the lncRNA INHEG was highly expressed in glioma stem cells (GSCs) compared to differentiated glioma cells and promoted GSC self-renewal and tumorigenicity through control of rRNA 2’-O-methylation.
[Nature Communications] |
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| Scientists identified that stabilizing vimentin phosphorylation at serine 56 induces multinucleation, specifically in hybrid epithelial-mesenchymal cells with stemness properties but not epithelial or mesenchymal cells.
[Cell Reports] |
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| In a well-established breast cancer stem cells model, investigators identified that pharmacological inhibition of the mechanistic target of rapamycin (mTOR), suppressed Sal-induced ferroptosis.
[Cell Death & Disease] |
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| Researchers investigated whether the combination of three markers, EpCAM, CD24, and Vimentin, could identify disseminating epithelial-mesenchymal transition CSCs in actual human tumors.
[eLife] |
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| Scientists revealed the critical mediators that regulated glycolytic metabolism reprogramming in gastric cancer and their underlying molecular mechanism.
[Journal of Translational Medicine] |
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| The authors found that NK cells in combination with tumor irradiation may provide synergistic therapeutic effects for NK cell recognition and elimination against both parental and stem-like liver cancer through lymphocyte function-associated antigen 1/intercellular adhesion molecule-1.
[International Journal Of Radiation Oncology Biology Physics] |
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| Knockdown of YTHDF1 and SIAH2, or overexpression of seven in absentia homology 2 (SIAH2) in vitro and in vivo, was conducted to evaluate the impact of changes in YTHDF1 and SIAH2 expression on triple-negative breast cancer cell proliferation, apoptosis, stemness, and Hippo pathway gene expression.
[Molecular Carcinogenesis] |
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| Investigators characterized how esophageal squamous cell carcinoma and preneoplastic cells respond to alcohol exposure using cell lines, three-dimensional organoids, and xenograft models.
[Carcinogenesis] |
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| Scientists discuss updated information regarding CSCs in the purinergic system and present evidence supporting the idea that elements of the purinergic system expressed by this subpopulation of the tumor represent attractive pharmacological targets for proposing innovative anti-cancer therapies.
[Purinergic Signalling] |
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| Dr. Bishoy M. Faltas, director of bladder cancer research at the Englander Institute for Precision Medicine at Weill Cornell Medicine has been awarded a $4 million, seven-year MERIT grant from the National Cancer Institute at the National Institutes of Health.
[Weill Cornell Medicine] |
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| December 4 – 7, 2023
Dublin, Ireland |
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| | Swammerdam Institute for Life Sciences – Amsterdam, Netherlands |
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| | Babraham Institute – Cambridge, England, United Kingdom |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | The Ohio State University – Columbus, Ohio, United States |
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