Cancer Stem Cell News Volume 12.44 | Nov 29 2023

    0
    81








    2023-11-29 | CSCN 12.44


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.44 – 29 November, 2023
    TOP STORY

    ID1 Expressing Macrophages Support Cancer Cell Stemness and Limit CD8+ T Cell Infiltration in Colorectal Cancer

    Researchers reported that high expression of inhibitor of differentiation 1 (ID1) in tumor-associated macrophages correlated with poor outcomes in patients with colorectal cancer.
    [Nature Communications]

    Full Article
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    PUBLICATIONSRanked by the impact factor of the journal

    Liver Cancer Stem Cell Dissemination and Metastasis: Uncovering the Role of NRCAM in Hepatocellular Carcinoma

    Scientists revealed the contributions of NRCAM to liver CSC function and hepatocellular carcinoma metastasis, and further explored its mechanism in detail.
    [Journal Of Experimental & Clinical Cancer Research]

    Full Article

    Inhibiting NR5A2 Targets Stemness in Pancreatic Cancer by Disrupting SOX2/MYC Signaling and Restoring Chemosensitivity

    The authors elucidated the function of the nuclear receptor subfamily 5, group A, member 2 (NR5A2) in the context of pancreatic CSCs.
    [Journal of Experimental & Clinical Cancer Research]

    Full ArticleGraphical Abstract

    The Promoting Effect and Mechanism of MAD2L2 on Stemness Maintenance and Malignant Progression in Glioma

    Scientists elucidated the role of Mitotic arrest deficient 2 like 2 (MAD2L2) in maintaining glioblastoma stemness and promoting malignant behaviors through the regulation of c-MYC.
    [Journal of Translational Medicine]

    Full Article

    RCC2 Promotes Prostate Cancer Cell Proliferation and Migration through Hh/GLI1 Signaling Pathway and Cancer Stem-Like Cells

    Researchers explored the function of regulator of chromosome condensation 2 (RCC2) on prostate cancer (PCa) development. They found that RCC2 promoted PCa development through Hh/Gli1 signaling pathway via regulating epithelial-mesenchymal transition and CSCs.
    [Biology Direct]

    Full Article

    TET1 Regulates Stem Cell Properties and Cell Cycle of Cancer Stem Cells in Triple-Negative Breast Cancer via DNA Demethylation

    Investigators revealed that TET1 could regulate the phenotype of CSCs via OCT4. Additionally, it could control the cell cycle by increasing CDK1 and CCNB1 levels.
    [Biochemical Pharmacology]

    AbstractGraphical Abstract

    1-Benzylimidazole Attenuates the Stemness of Breast Cancer Cells through Partially Targeting CYP4Z1

    RNA sequencing found that 1-benzylimidazole held a preferable correlation with breast cancer and suppressed the expression of CSC makers.
    [Environmental Toxicology]

    Abstract

    Inhibition of Mitochondria Induces Apoptosis and Reduces Telomere Length and Activity in Acute Myeloid Leukemia Stem Cells

    Investigators evaluated whether leukemia stem cells was influenced by mitochondrial inhibition. They demonstrated that the inhibition of mitochondrial activity by tigecycline affects CSCs in comparison with other cells.
    [Cell Biochemistry And Function]

    Abstract

    Transcription Factor MITF Inhibits the Transcription of CPT1B to Regulate Fatty Acid β-Oxidation and Thus Affects Stemness in Lung Adenocarcinoma Cells

    Transcription factor MITF inhibited transcription of CPT1B to regulate fatty acid β-oxidation, thereby suppressing stemness in lung adenocarcinoma cells.
    [Pharmacology]

    Full Article
    Connect with us via LiveChat to ask your scientific support questions
    REVIEWS

    Sniping Cancer Stem Cells with Nanomaterials

    Scientists provide an update on the current landscape of nanobased precision targeting approaches against CSCs. They elucidate the nuanced application of organic, inorganic, and bioinspired nanomaterials across a spectrum of therapeutic paradigms, encompassing targeted therapy, and more.
    [ACS Nano]

    AbstractGraphical Abstract

    Predominant Factors Influencing Reactive Oxygen Species in Cancer Stem Cells

    The authors summarize the mechanisms of redox regulation in CSCs, with a focus on therapy resistance, its various pathways and microRNA regulation, and the potential therapeutic implications of manipulating the reactive oxygen species levels to eradicate CSCs.
    [Journal of Cellular Biochemistry]

    Abstract
    INDUSTRY AND POLICY NEWS

    Montefiore Einstein Comprehensive Cancer Center Awarded FDA Grant for Clinical Trial on Experimental AML/MDS Treatment

    Researchers at the Montefiore Einstein Comprehensive Cancer Center were awarded a $2.6 million grant from the US FDA to conduct an innovative Phase I clinical trial of a new drug for patients with relapsed and treatment-resistant forms of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
    [Albert Einstein College of Medicine]

    Press Release
    FEATURED EVENT

    Stem Cells and Regeneration

    January 22 – 25, 2024
    Santa Fe, New Mexico, United States

    > See All Events

    JOB OPPORTUNITIES

    Faculty Positions – Medicine

    Westlake University – Zhejiang, China

    Assistant Professor Position – 3D Tissue Organoids

    Swammerdam Institute for Life Sciences – Amsterdam, Netherlands

    Animal Technician – Experimental Therapeutics

    BC Cancer – Vancouver, British Columbia, Canada

    Research Assistant – Epigenetics

    Babraham Institute – Cambridge, England, United Kingdom

    PhD Student – Cancer Science

    University of Oxford – Oxford, England, United Kingdom

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2