Cancer Stem Cell News Volume 12.46 | Dec 13 2023

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    2023-12-13 | CSCN 12.46


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.46 – 13 December, 2023
    TOP STORY

    Fibroblast-Derived Lysyl Oxidase Increases Oxidative Phosphorylation and Stemness in Cholangiocarcinoma

    Investigators demonstrated how lysyl oxidase, a known factor in collagen crosslinking, contributed to the development and progression of cholangiocarcinoma.
    [Gastroenterology]

    AbstractFull ArticleGraphical Abstract
    Learn more about using human primary cells for your assays
    PUBLICATIONSRanked by the impact factor of the journal

    Visualizing Cancer-Originating Acetate Uptake through MCT1 in Reactive Astrocytes in the Glioblastoma Tumor Microenvironment

    Researchers explored acetate from glioblastoma cells, which triggered reactive astrogliosis in neighboring astrocytes by upregulating MAO-B and MCT1 expression.
    [Neuro-Oncology]

    AbstractGraphical Abstract

    POU5F1 Promotes the Proliferation, Migration, and Invasion of Gastric Cancer Cells by Reducing the Ubiquitination Level of TRAF6

    Scientists investigated the impact of POU5F1 on the proliferation, migration, and invasion of gastric cancer cells through both in vivo and in vitro experiments.
    [Cell Death & Disease]

    Full Article

    Novel lncRNA Gm33149 Modulates Metastatic Heterogeneity in Melanoma by Regulating the miR-5623-3p/Wnt Axis via Exosomal Transfer

    Researchers investigated the role and mechanism of long non-coding RNAs in regulating the interaction between melanoma CSCs and non-CSCs during the metastatic colonization process.
    [Cancer Gene Therapy]

    Abstract

    SIRT6 Promotes Metastasis and Relapse in HER2-Positive Breast Cancer

    Scientists investigated the impact of sirtuin 6 (SIRT6)-overexpression in Delta16HER2 mice, which were a bona fide model of HER2-positive breast cancer.
    [Scientific Reports]

    Full Article

    RFX2 Promotes Tumor Cell Stemness through Epigenetic Regulation of PAF1 in Spinal Ependymoma

    The authors investigated the molecular mechanism that induced stem cell features in spinal ependymoma (SE). They found that RFX2 activates PAF1 transcription, which promoted tumor stemness of SE cells and led to the malignant progression of SE.
    [Journal of Neuro-Oncology]

    Abstract

    TRIM28 Suppresses Cancer Stem-Like Characteristics in Gastric Cancer Cells through Wnt/β-Catenin Signaling Pathways

    Investigators explored the important effects of TRIM28 on gastric cancer (GC) and uncovered underling molecular mechanisms. They found that TRIM28 has an important influence on regulating the stem-like property of GC cell via Wnt/β-catenin signaling.
    [Experimental Biology and Medicine]

    Abstract

    Boric Acid Alters the Expression of DNA Double Break Repair Genes in MCF-7-Derived Breast Cancer Stem Cells

    The authors investigated the effects of boric acid on the expression of DNA double-strand break repair genes in breast CSCs, which has not been studied in the literature before.
    [Biological Trace Element Research]

    AbstractGraphical Abstract

    RNF183 Promotes Colon Cancer Cell Stemness through Fatty Acid Oxidation

    Researchers explored the role of RNF183 on colon cancer (COAD). They found that RNF183 promoted COAD stemness by affecting fatty acid oxidation.
    [Nutrition And Cancer-An International Journal]

    Abstract
    Request a free copy of this wallchart for an overview of the different types of pluripotent cells
    REVIEWS

    Biomarkers and Targeted Therapy for Cancer Stem Cells

    Scientists provide an overview of the unique signaling and metabolic pathways of CSCs, summarize existing CSC biomarkers and CSC-targeted therapies, and discuss strategies to further differentiate CSCs from non-stem cancer cells.
    [Trends In Pharmacological Sciences]

    Abstract

    BMP Signaling in Cancer Stemness and Differentiation

    The authors provide a concise overview highlighting the diverse roles of bone morphogenetic protein (BMP) signaling in various types of cancers.
    [Cell Regeneration]

    Full Article
    INDUSTRY AND POLICY NEWS

    Surge in Number of ‘Extremely Productive’ Authors Concerns Scientists

    Some researchers publish a new paper every five days, on average. Data trackers suspect not all their manuscripts were produced through honest labor.
    [Nature]

    News Article
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